在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

API5 Antibody

  • 中文名稱:
    API5兔多克隆抗體
  • 貨號:
    CSB-PA042409
  • 規(guī)格:
    ¥1100
  • 圖片:
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Hela cells, MCF7 cells, A549 cells, Lovo cells, Primary antibody: CSB-PA042409(API5 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    API5
  • 別名:
    AAC 11 antibody; AAC-11 antibody; AAC11 antibody; Antiapoptosis clone 11 protein antibody; API 5 antibody; API-5 antibody; api5 antibody; API5 like 1 antibody; API5_HUMAN antibody; API5L1 antibody; Apoptosis inhibitor 5 antibody; Cell migration inducing gene 8 protein antibody; Cell migration-inducing gene 8 protein antibody; Fibroblast growth factor 2 interacting factor 2 antibody; Fibroblast growth factor 2-interacting factor antibody; FIF antibody; MIG 8 antibody; MIG8 antibody; Migration inducing protein MIG8 antibody; Protein XAGL antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthetic peptide of Human API5
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.
  • 基因功能參考文獻:
    1. study demonstrates that apoptosis inhibitor 5 is an endogenous and direct inhibitor of caspase-2. API5 protein directly binds to the caspase recruitment domain (CARD) of caspase-2 and impedes dimerization and activation of caspase-2. PMID: 28336776
    2. Authors propose a proapoptotic role for NP in IAV pathogenesis, whereby it suppresses expression of antiapoptotic factor API5, thus potentiating the E2F1-dependent apoptotic pathway and ensuring viral replication. PMID: 26673663
    3. Authors show that API5 increases the metastatic capacity of cervical cancer cells in vitro and in vivo via up-regulation of MMP-9. PMID: 25248562
    4. rs17684886 (ZNRF1) and rs599019 (COLEC12) are associated with diabetic retinopathy and rs6427247 (SCYL1BP1) and rs899036 (API5) are associated with severe diabetic retinopathy in Chinese patients with type 2 diabetes PMID: 25819896
    5. API5 overexpression promoted cell proliferation and colony formation in CaSki cancer cells, whereas API5 knockdown inhibited the both properties in HeLa cells; API5 expression is associated with pERK1/2 in a subset of cervical cancer patients and its expression predicts poor overall survival. PMID: 25070070
    6. miR-143 and miR-145 and the predicted target proteins API5, ERK5, K-RAS, and IRS-1 display regional differences in expression in the colon PMID: 25477374
    7. Negative regulation of API-5 expression by miR-1 was demonstrated to promote apoptosis of HepG2 cells. PMID: 25433291
    8. API5 acts as an immune escape gene in tumors by rendering them resistant to apoptosis triggered by tumor antigen-specific T cells. PMID: 24769442
    9. Low miR-224 and high API5 expression correlated with worse survival of glioblastoma patients. PMID: 24785373
    10. Api5, even if not physically interacting with E2F1, contributes positively to E2F1 transcriptional activity by increasing E2F1 binding to its target promoters. PMID: 23940755
    11. structure and function of API5 PMID: 22334682
    12. The prognostic significance of the genes casein kinase 2 alpha subunit (CSNK2A1), anti-apoptosis clone-11 (AAC-11), and tumor metastasis suppressor NME1 in completely resected non-small cell lung cancer (NSCLC) patients, was analysed. PMID: 20671611
    13. we infer that Pim-2 could activate API-5 to inhibit the apoptosis of liver cells, and NF-kappaB is the key regulator PMID: 19821157
    14. Apoptosis inhibitor-5/antiapoptosis clone-11 (Api5/Aac11) is a critical determinant of dE2F1-induced apoptosis in vivo and in vitro. PMID: 17112319
    15. define a true in vivo target of miR-224 and reaffirm the important role of miRNAs in the dysregulation of cellular processes that may ultimately lead to tumorigenesis PMID: 18319255
    16. The authors report here that AAC-11, a survival protein whose expression prevents apoptosis that occurs on deprivation of growth factors, physiologically binds to Acinus and prevents Acinus-mediated DNA fragmentation. PMID: 19387494

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm. Note=Mainly nuclear. Can also be cytoplasmic.; [Isoform 3]: Cytoplasm.
  • 蛋白家族:
    API5 family
  • 組織特異性:
    Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in heart, pancreas and placenta. Highly expressed in several cancers. Preferentially expressed in squamous cell carcinoma
  • 數(shù)據(jù)庫鏈接:

    HGNC: 594

    OMIM: 609774

    KEGG: hsa:8539

    STRING: 9606.ENSP00000431391

    UniGene: Hs.435771



主站蜘蛛池模板: 精品国产乱码久久久久久下载| 兔费看少妇性l交大片免费| 丰满人妻一区二区三区无码av| 免费va国产高清大片在线| 亚洲精品一卡2卡三卡4卡| 久久精品aⅴ无码中文字字幕蜜桃 午夜成人鲁丝片午夜精品 | 日本成熟老妇乱| 亚洲欧洲自拍拍偷综合| 国产亚洲欧洲aⅴ综合一区| 少妇无码吹潮| 国语精品福利自产拍在线观看| 国产精品美女久久久浪潮av| 日本一卡2卡3卡4卡免费精品| 日韩人妻中文无码一区二区三区| 免费无码毛片一区二区app| 国产精品人人妻人人爽| 无码国产玉足脚交极品网站| 国产精品久久久久影院色| 午夜男女爽爽影院免费视频下载| 一本丁香综合久久久久不卡网站 | 久久免费的精品国产v∧| 亚洲中文字幕无码人在线| 欧美黑人性暴力猛交喷水| 久久午夜无码鲁丝片| 曰本女人与公拘交酡| 成在人线av无码免费高潮喷水| 男女边吃奶边做边爱视频| 国产乱子夫妻xx黑人xyx真爽| 免费视频爱爱太爽了激情| 在线 国产 精品 蜜芽| av永久天堂一区二区三区| 尤物yw193无码点击进入| 午夜dj高清免费观看视频| 欧美老肥妇多毛xxxxx| 国产精品综合色区在线观看| 羞羞视频在线观看| 香港曰本韩国三级网站| 在教室伦流澡到高潮hgl视频| 日本一二三区视频在线| 久久精品国产99精品亚洲| 国产精品视频二区不卡|