在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

API5 Antibody

  • 中文名稱:
    API5兔多克隆抗體
  • 貨號(hào):
    CSB-PA276563
  • 規(guī)格:
    ¥1100
  • 圖片:
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: 293T cells, A549 cells, Hela cells, Primary antibody: CSB-PA276563(API5 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    API5
  • 別名:
    AAC 11 antibody; AAC-11 antibody; AAC11 antibody; Antiapoptosis clone 11 protein antibody; API 5 antibody; API-5 antibody; api5 antibody; API5 like 1 antibody; API5_HUMAN antibody; API5L1 antibody; Apoptosis inhibitor 5 antibody; Cell migration inducing gene 8 protein antibody; Cell migration-inducing gene 8 protein antibody; Fibroblast growth factor 2 interacting factor 2 antibody; Fibroblast growth factor 2-interacting factor antibody; FIF antibody; MIG 8 antibody; MIG8 antibody; Migration inducing protein MIG8 antibody; Protein XAGL antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Synthetic peptide of Human API5
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.
  • 基因功能參考文獻(xiàn):
    1. study demonstrates that apoptosis inhibitor 5 is an endogenous and direct inhibitor of caspase-2. API5 protein directly binds to the caspase recruitment domain (CARD) of caspase-2 and impedes dimerization and activation of caspase-2. PMID: 28336776
    2. Authors propose a proapoptotic role for NP in IAV pathogenesis, whereby it suppresses expression of antiapoptotic factor API5, thus potentiating the E2F1-dependent apoptotic pathway and ensuring viral replication. PMID: 26673663
    3. Authors show that API5 increases the metastatic capacity of cervical cancer cells in vitro and in vivo via up-regulation of MMP-9. PMID: 25248562
    4. rs17684886 (ZNRF1) and rs599019 (COLEC12) are associated with diabetic retinopathy and rs6427247 (SCYL1BP1) and rs899036 (API5) are associated with severe diabetic retinopathy in Chinese patients with type 2 diabetes PMID: 25819896
    5. API5 overexpression promoted cell proliferation and colony formation in CaSki cancer cells, whereas API5 knockdown inhibited the both properties in HeLa cells; API5 expression is associated with pERK1/2 in a subset of cervical cancer patients and its expression predicts poor overall survival. PMID: 25070070
    6. miR-143 and miR-145 and the predicted target proteins API5, ERK5, K-RAS, and IRS-1 display regional differences in expression in the colon PMID: 25477374
    7. Negative regulation of API-5 expression by miR-1 was demonstrated to promote apoptosis of HepG2 cells. PMID: 25433291
    8. API5 acts as an immune escape gene in tumors by rendering them resistant to apoptosis triggered by tumor antigen-specific T cells. PMID: 24769442
    9. Low miR-224 and high API5 expression correlated with worse survival of glioblastoma patients. PMID: 24785373
    10. Api5, even if not physically interacting with E2F1, contributes positively to E2F1 transcriptional activity by increasing E2F1 binding to its target promoters. PMID: 23940755
    11. structure and function of API5 PMID: 22334682
    12. The prognostic significance of the genes casein kinase 2 alpha subunit (CSNK2A1), anti-apoptosis clone-11 (AAC-11), and tumor metastasis suppressor NME1 in completely resected non-small cell lung cancer (NSCLC) patients, was analysed. PMID: 20671611
    13. we infer that Pim-2 could activate API-5 to inhibit the apoptosis of liver cells, and NF-kappaB is the key regulator PMID: 19821157
    14. Apoptosis inhibitor-5/antiapoptosis clone-11 (Api5/Aac11) is a critical determinant of dE2F1-induced apoptosis in vivo and in vitro. PMID: 17112319
    15. define a true in vivo target of miR-224 and reaffirm the important role of miRNAs in the dysregulation of cellular processes that may ultimately lead to tumorigenesis PMID: 18319255
    16. The authors report here that AAC-11, a survival protein whose expression prevents apoptosis that occurs on deprivation of growth factors, physiologically binds to Acinus and prevents Acinus-mediated DNA fragmentation. PMID: 19387494

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Nucleus. Cytoplasm. Note=Mainly nuclear. Can also be cytoplasmic.; [Isoform 3]: Cytoplasm.
  • 蛋白家族:
    API5 family
  • 組織特異性:
    Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in heart, pancreas and placenta. Highly expressed in several cancers. Preferentially expressed in squamous cell carcinoma
  • 數(shù)據(jù)庫鏈接:

    HGNC: 594

    OMIM: 609774

    KEGG: hsa:8539

    STRING: 9606.ENSP00000431391

    UniGene: Hs.435771



主站蜘蛛池模板: 亚洲国产婷婷香蕉久久久久久| 色伦专区97中文字幕| 欧美婷婷丁香五月社区| 国产av无码精品色午夜| 国产性色αv视频免费 | 越南毛茸茸的少妇| 亚洲乱亚洲乱少妇无码99p| 青草视频在线播放| 激情综合色五月六月婷婷 | 国产成人精品一区二区三区免费| 青青草原综合久久大伊人精品 | 国产拍揄自揄免费观看| 人妻在线无码一区二区三区| 婷婷色婷婷开心五月四房播播| 国产三级av在线播放| 久久精品中文字幕一区二区三区| 国产爆乳无码视频在线观看3| 欧美熟妇丰满肥白大屁股免费视频 | 尤物yw午夜国产精品大臿蕉| 国内一区二区三区香蕉aⅴ| 国产女人抽搐喷浆视频| 精品综合久久久久久888蜜芽| 国产丰满麻豆videossexhd | 久久99亚洲网美利坚合众国| 人妻少妇伦在线麻豆m电影| 无码人妻少妇精品无码专区漫画| 男女啪啪激烈高潮喷出gif免费| 人妻少妇熟女javhd| 国产成人一区二区三区| 欧美国产成人精品一区二区三区| 亚洲精品熟女国产| 欧美综合乱图图区乱图图区 | 99久久精品视香蕉蕉| 伊人色综合一区二区三区| 男人添女人下部高潮视频| 国产69精品久久久久乱码| 日韩人妻ol丝袜av一二区| 一本一本久久aa综合精品| 国产日产精品久久快鸭的功能介绍| 成人一区二区免费中文字幕视频| 女人夜夜春高潮爽a∨片|