在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

APC2 Antibody, FITC conjugated

  • 中文名稱:
    APC2兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA001895LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) APC2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Adenomatous polyposis coli protein 2 antibody; Adenomatous polyposis coli protein-like antibody; APC-like antibody; apc2 antibody; APC2_HUMAN antibody; APCL antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Adenomatous polyposis coli protein 2 protein (2011-2221AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases. May also function in Wnt signaling by promoting the rapid degradation of CTNNB1.
  • 基因功能參考文獻:
    1. It has been found that APC2 localizes as distinct clusters along microtubule bundles in dendrites, and that this localization is driven by LC8-binding and two separate microtubule-interacting domains. PMID: 30018294
    2. double knockdown of APC2 and miR-4326 promoted lung cancer cell proliferation, confirming that miR-4326 promoted lung cancer cell proliferation by inhibiting APC2. PMID: 29101731
    3. APC2 3'-UTR is targeted by hsa-miR-11181. PMID: 29111205
    4. Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium PMID: 27694902
    5. Data show that poly(ADP-ribose) polymerase (PARP) enzyme Tankyrase (TNKS) inhibition in colon cancer cells decreases beta-catenin signaling at the level of both Axin and APC2. PMID: 27068743
    6. miR-939 functioned as a potential tumor promoter by regulating the Wnt/beta-catenin signal pathway through direct suppression of APC2 expression. PMID: 25960217
    7. We report that APC-2 gene is hypermethylated in both RB tumor samples and Y79 cells. Reduced APC-2 lead to increased Wnt signaling pathway protein, beta-catenin suggesting tumor suppressive role of APC-2 gene. PMID: 25207834
    8. APCL uses the 15 amino acid repeats region of APC to target beta-catenin for degradation. PMID: 23840886
    9. These data suggest that APC2 does not have to shuttle into the nucleus or localize to a particular subcellular location to regulate Wnt signaling. PMID: 22513088
    10. Familial adenomatous polyposis with adenomatous polyposis coli gene mutation at codon 1309 entails a risk of a more aggressive phenotype; early colectomy may be indicated in children harboring this gene mutation. PMID: 18157572

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Sotos syndrome 3 (SOTOS3)
  • 亞細胞定位:
    Cytoplasm, cytoskeleton. Golgi apparatus. Cytoplasm. Cytoplasm, perinuclear region.
  • 蛋白家族:
    Adenomatous polyposis coli (APC) family
  • 組織特異性:
    Widely expressed (at protein level). Specifically expressed in the CNS.
  • 數據庫鏈接:

    HGNC: 24036

    OMIM: 612034

    KEGG: hsa:10297

    STRING: 9606.ENSP00000233607

    UniGene: Hs.446376



主站蜘蛛池模板: 丝袜无码一区二区三区| 亚洲欧美综合在线天堂| 少妇中文字幕乱码亚洲影视| 日韩精品人妻中文字幕有码| 高潮喷水无码av亚洲| 久久精品国产99精品亚洲| 97精品尹人久久大香线蕉| 大胆欧美熟妇xx| 国产欧美综合一区二区三区| 欧美人与动交视频在线观看| 亚洲国产欧美在线观看片不卡| 国产乱子伦精品无码码专区| 国产成人精品视频一区二区不卡| 久久久久香蕉国产线看观看伊 | 日本两人免费观看的视频| 国产色诱视频在线播放网站| 女人高潮抽搐喷液30分钟视频| 任我撸在线视频| 性欧美性另类巨大| 久久se精品一区二区三区| 国产精品日本一区二区不卡视频| 国产精品内射后入合集| 妇女性内射冈站hdwww000| 日日橹狠狠爱欧美视频| 国产av天堂亚洲国产av麻豆| 午夜福利电影| 久久无码av三级| 成人无码嫩草影院| 亚洲国产精品久久久久秋霞小| 久久棈精品久久久久久噜噜| 国产人妻久久精品二区三区特黄 | 久久精品国产99久久无毒不卡| 成年无码动漫av片在线尤物网站| 久久丫精品忘忧草西安产品| 欧美黑人欧美精品刺激| 香蕉啪视频在线观看视频久| 白嫩少妇激情无码| 在厨房拨开内裤进入毛片| 东京热一精品无码av| 国产精品美女乱子伦高潮| 日日碰狠狠丁香久燥|