在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

APC2 Antibody, Biotin conjugated

  • 中文名稱:
    APC2兔多克隆抗體, Biotin偶聯(lián)
  • 貨號:
    CSB-PA001895LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) APC2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Adenomatous polyposis coli protein 2 antibody; Adenomatous polyposis coli protein-like antibody; APC-like antibody; apc2 antibody; APC2_HUMAN antibody; APCL antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Adenomatous polyposis coli protein 2 protein (2011-2221AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能:
    Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases. May also function in Wnt signaling by promoting the rapid degradation of CTNNB1.
  • 基因功能參考文獻(xiàn):
    1. It has been found that APC2 localizes as distinct clusters along microtubule bundles in dendrites, and that this localization is driven by LC8-binding and two separate microtubule-interacting domains. PMID: 30018294
    2. double knockdown of APC2 and miR-4326 promoted lung cancer cell proliferation, confirming that miR-4326 promoted lung cancer cell proliferation by inhibiting APC2. PMID: 29101731
    3. APC2 3'-UTR is targeted by hsa-miR-11181. PMID: 29111205
    4. Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium PMID: 27694902
    5. Data show that poly(ADP-ribose) polymerase (PARP) enzyme Tankyrase (TNKS) inhibition in colon cancer cells decreases beta-catenin signaling at the level of both Axin and APC2. PMID: 27068743
    6. miR-939 functioned as a potential tumor promoter by regulating the Wnt/beta-catenin signal pathway through direct suppression of APC2 expression. PMID: 25960217
    7. We report that APC-2 gene is hypermethylated in both RB tumor samples and Y79 cells. Reduced APC-2 lead to increased Wnt signaling pathway protein, beta-catenin suggesting tumor suppressive role of APC-2 gene. PMID: 25207834
    8. APCL uses the 15 amino acid repeats region of APC to target beta-catenin for degradation. PMID: 23840886
    9. These data suggest that APC2 does not have to shuttle into the nucleus or localize to a particular subcellular location to regulate Wnt signaling. PMID: 22513088
    10. Familial adenomatous polyposis with adenomatous polyposis coli gene mutation at codon 1309 entails a risk of a more aggressive phenotype; early colectomy may be indicated in children harboring this gene mutation. PMID: 18157572

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Sotos syndrome 3 (SOTOS3)
  • 亞細(xì)胞定位:
    Cytoplasm, cytoskeleton. Golgi apparatus. Cytoplasm. Cytoplasm, perinuclear region.
  • 蛋白家族:
    Adenomatous polyposis coli (APC) family
  • 組織特異性:
    Widely expressed (at protein level). Specifically expressed in the CNS.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 24036

    OMIM: 612034

    KEGG: hsa:10297

    STRING: 9606.ENSP00000233607

    UniGene: Hs.446376



主站蜘蛛池模板: 一本本月无码-| 色婷婷国产精品高潮呻吟av久久| 国产精品成人a区在线观看| 中文字幕av中文字无码亚| 国产免费午夜福利在线播放11| 18禁无遮挡羞羞污污污污网站| 人妻熟女一区二区aⅴ清水理纱| 久久久久久a亚洲欧洲av冫| 一卡二卡三卡视频| 久久香港三级台湾三级播放 | 国产欲女高潮正在播放| 亚洲 日韩 欧美 有码 在线| 国产婷婷丁香五月缴情成人网| 亚洲色成人www永久在线观看| 成人午夜福利视频镇东影视| 亚洲小说区图片区另类春色| 亚洲色成人网站www永久蜜芽| 国产福利无码一区在线| 国产成人愉拍精品| 特级精品毛片免费观看| 国产亚洲成av片在线观看| 国产亚洲精aa在线观看不卡| 国产成人精品午夜福利不卡| 午夜福利三级理论电影| 午夜欧美精品久久久久久久| av无码国产精品麻豆| 国产精品aⅴ视频在线播放| 久久久久人妻一区精品性色av| 国产成人精品亚洲午夜麻豆| 怡春院国产精品视频| 免费人成网站视频在线观看国内 | 伊人久久大香线蕉avapp下载| 国产亚洲欧美日韩在线观看一区 | 欧美日韩无砖专区一中文字| 欧美又粗又大aaa片| 4438xx亚洲最大五色丁香| 亚洲另类成人小说综合网| 久久精品九九亚洲精品天堂| 大肉大捧一进一出好爽| 亚洲中文字幕无码av| 全球成人中文在线|