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APC2 Antibody, Biotin conjugated

  • 中文名稱:
    APC2兔多克隆抗體, Biotin偶聯(lián)
  • 貨號:
    CSB-PA001895LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) APC2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Adenomatous polyposis coli protein 2 antibody; Adenomatous polyposis coli protein-like antibody; APC-like antibody; apc2 antibody; APC2_HUMAN antibody; APCL antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Adenomatous polyposis coli protein 2 protein (2011-2221AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能:
    Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases. May also function in Wnt signaling by promoting the rapid degradation of CTNNB1.
  • 基因功能參考文獻(xiàn):
    1. It has been found that APC2 localizes as distinct clusters along microtubule bundles in dendrites, and that this localization is driven by LC8-binding and two separate microtubule-interacting domains. PMID: 30018294
    2. double knockdown of APC2 and miR-4326 promoted lung cancer cell proliferation, confirming that miR-4326 promoted lung cancer cell proliferation by inhibiting APC2. PMID: 29101731
    3. APC2 3'-UTR is targeted by hsa-miR-11181. PMID: 29111205
    4. Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium PMID: 27694902
    5. Data show that poly(ADP-ribose) polymerase (PARP) enzyme Tankyrase (TNKS) inhibition in colon cancer cells decreases beta-catenin signaling at the level of both Axin and APC2. PMID: 27068743
    6. miR-939 functioned as a potential tumor promoter by regulating the Wnt/beta-catenin signal pathway through direct suppression of APC2 expression. PMID: 25960217
    7. We report that APC-2 gene is hypermethylated in both RB tumor samples and Y79 cells. Reduced APC-2 lead to increased Wnt signaling pathway protein, beta-catenin suggesting tumor suppressive role of APC-2 gene. PMID: 25207834
    8. APCL uses the 15 amino acid repeats region of APC to target beta-catenin for degradation. PMID: 23840886
    9. These data suggest that APC2 does not have to shuttle into the nucleus or localize to a particular subcellular location to regulate Wnt signaling. PMID: 22513088
    10. Familial adenomatous polyposis with adenomatous polyposis coli gene mutation at codon 1309 entails a risk of a more aggressive phenotype; early colectomy may be indicated in children harboring this gene mutation. PMID: 18157572

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  • 相關(guān)疾病:
    Sotos syndrome 3 (SOTOS3)
  • 亞細(xì)胞定位:
    Cytoplasm, cytoskeleton. Golgi apparatus. Cytoplasm. Cytoplasm, perinuclear region.
  • 蛋白家族:
    Adenomatous polyposis coli (APC) family
  • 組織特異性:
    Widely expressed (at protein level). Specifically expressed in the CNS.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 24036

    OMIM: 612034

    KEGG: hsa:10297

    STRING: 9606.ENSP00000233607

    UniGene: Hs.446376



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