在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

AP2A1 Antibody

  • 中文名稱:
    AP2A1兔多克隆抗體
  • 貨號:
    CSB-PA995615
  • 規(guī)格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA995615(AP2A1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-3: A431, 231 and NIH/3T3 cell, Primary antibody: CSB-PA995615(AP2A1 Antibody) at dilution 1/250 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    100 kDa coated vesicle protein A antibody; Adapter-related protein complex 2 alpha-1 subunit antibody; adapter-related protein complex 2 subunit alpha-1 antibody; Adaptin alpha A antibody; Adaptin alpha antibody; Adaptor protein complex AP 2 alpha 1 subunit antibody; adaptor protein complex AP 2 subunit alpha 1 antibody; Adaptor protein complex AP-2 subunit alpha-1 antibody; Adaptor protein complex AP2 alpha 1 subunit antibody; adaptor protein complex AP2 subunit alpha 1 antibody; Adaptor related protein complex 2 alpha 1 subunit antibody; Adaptor related protein complex AP 2 alpha 1 subunit antibody; Adaptor related protein complex AP2 alpha 1 subunit antibody; ADTAA antibody; Alpha A adaptin antibody; Alpha adaptin A antibody; Alpha-adaptin A antibody; alpha1 adaptin antibody; Alpha1-adaptin antibody; AP 2 alpha antibody; AP 2 complex subunit alpha 1 antibody; AP-2 complex subunit alpha-1 antibody; AP2 complex subunit alpha 1 antibody; AP2-ALPHA antibody; Ap2a1 antibody; AP2A1_HUMAN antibody; CLAPA 1 antibody; CLAPA1 antibody; Clathrin adaptor complex AP2. alpha subunit antibody; Clathrin assembly protein complex 2 alpha A large chain antibody; Clathrin assembly protein complex 2 alpha-A large chain antibody; Clathrin associated / assembly / adaptor protein large alpha 1 antibody; clathrin associated assembly adaptor protein large alpha 1 antibody; clathrin associated/assembly/adaptor protein, large, alpha 1 antibody; Plasma membrane adaptor HA 2/AP 2 adaptin alpha A subunit antibody; Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse
  • 免疫原:
    Synthetic peptide of Human AP2A1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif.
  • 基因功能參考文獻:
    1. Results revealed thirteen novel splice junctions of previously annotated exons. Consecutive nested PCRs led to the determination of the primary structure of seventy-seven novel AP2A1 transcripts, all of which were shown to comprise at least one premature translation termination codon, thus representing nonsense-mediated mRNA decay candidates. PMID: 30081190
    2. AP-2alpha depletion enhanced apoptosis, demonstrating that disrupting the HIV-1 Nef:AP-2alpha interaction limits Nef-mediated apoptosis. PMID: 28577469
    3. These results lead to a model for the docking of the full AP-2 tetramer to membranes as bound to Nef, such that the cytosolic tail of CD4 is situated to interact with its binding site on Nef. PMID: 24473078
    4. A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration. PMID: 22360420
    5. AP2alpha negatively regulates HIV-1 replication in the process of nuclear translocation of viral DNA in the cytoplasm or the perinuclear region. PMID: 18178234
    6. nef usurps AP-2 complexes to dysregulate Ii (invariant chain (Ii)/major histocompatibility complex class II) trafficking and potentially interfere with antigen presentation in the context of MHC-II PMID: 18524831

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族:
    Adaptor complexes large subunit family
  • 組織特異性:
    Expressed in the brain (at protein level). Isoform A: Expressed in forebrain, skeletal muscle, spinal cord, cerebellum, salivary gland, heart and colon. Isoform B: Widely expressed in tissues and also in breast cancer and in prostate carcinoma cells.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 561

    OMIM: 601026

    KEGG: hsa:160

    STRING: 9606.ENSP00000351926

    UniGene: Hs.467125



主站蜘蛛池模板: 永久免费的啪啪网站免费观看| 宅宅少妇无码| 亚洲欧洲美洲无码精品va| 奇米777国产在线视频| 艳妇乳肉豪妇荡乳在线观看 | 国产日韩综合一区二区性色av| 真实国产乱子伦视频| 男女猛烈无遮挡免费视频app| 国产精品区av| 熟女人妻一区二区三区免费看| 亚洲国产最大av| 岛国在线无码高清视频| 女人喷潮完整视频| 人妻内射一区二区在线视频| 亚洲中文字幕aⅴ无码天堂| 国产精品va无码二区| 337p日本欧洲亚洲大胆张筱雨| 国产无遮挡又黄又爽又色| 肉感饱满中年熟妇日本| 欧美成aⅴ人高清ww| 欧美人与性动交ccoo| 成人免费一区二区三区视频| 国产xxxx色视频在线观看| av无码欧洲亚洲电影网| 18禁男女爽爽爽午夜网站免费| 特级a做爰全过程片| 国模国产精品嫩模大尺度视频| 精品亚洲aⅴ在线无码播放| 在线观看肉片av网站免费| 日本熟妇人妻xxxxx| 无码少妇一区二区三区浪潮av| 精品人成视频免费国产| 欧美国产精品日韩在线| 欧美成人精品三级一二三在线观看 | 亚洲小说区图片区另类春色| 国产精品sm捆绑调教视频| 国产乱码二卡3卡四卡| 一本一本久久a久久精品综合| 色v99在线影院| 亚洲人成在线观看网站无码| 日本高清aⅴ毛片免费|