在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

AP2A1 Antibody

  • 中文名稱:
    AP2A1兔多克隆抗體
  • 貨號:
    CSB-PA995615
  • 規(guī)格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA995615(AP2A1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-3: A431, 231 and NIH/3T3 cell, Primary antibody: CSB-PA995615(AP2A1 Antibody) at dilution 1/250 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    100 kDa coated vesicle protein A antibody; Adapter-related protein complex 2 alpha-1 subunit antibody; adapter-related protein complex 2 subunit alpha-1 antibody; Adaptin alpha A antibody; Adaptin alpha antibody; Adaptor protein complex AP 2 alpha 1 subunit antibody; adaptor protein complex AP 2 subunit alpha 1 antibody; Adaptor protein complex AP-2 subunit alpha-1 antibody; Adaptor protein complex AP2 alpha 1 subunit antibody; adaptor protein complex AP2 subunit alpha 1 antibody; Adaptor related protein complex 2 alpha 1 subunit antibody; Adaptor related protein complex AP 2 alpha 1 subunit antibody; Adaptor related protein complex AP2 alpha 1 subunit antibody; ADTAA antibody; Alpha A adaptin antibody; Alpha adaptin A antibody; Alpha-adaptin A antibody; alpha1 adaptin antibody; Alpha1-adaptin antibody; AP 2 alpha antibody; AP 2 complex subunit alpha 1 antibody; AP-2 complex subunit alpha-1 antibody; AP2 complex subunit alpha 1 antibody; AP2-ALPHA antibody; Ap2a1 antibody; AP2A1_HUMAN antibody; CLAPA 1 antibody; CLAPA1 antibody; Clathrin adaptor complex AP2. alpha subunit antibody; Clathrin assembly protein complex 2 alpha A large chain antibody; Clathrin assembly protein complex 2 alpha-A large chain antibody; Clathrin associated / assembly / adaptor protein large alpha 1 antibody; clathrin associated assembly adaptor protein large alpha 1 antibody; clathrin associated/assembly/adaptor protein, large, alpha 1 antibody; Plasma membrane adaptor HA 2/AP 2 adaptin alpha A subunit antibody; Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse
  • 免疫原:
    Synthetic peptide of Human AP2A1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif.
  • 基因功能參考文獻:
    1. Results revealed thirteen novel splice junctions of previously annotated exons. Consecutive nested PCRs led to the determination of the primary structure of seventy-seven novel AP2A1 transcripts, all of which were shown to comprise at least one premature translation termination codon, thus representing nonsense-mediated mRNA decay candidates. PMID: 30081190
    2. AP-2alpha depletion enhanced apoptosis, demonstrating that disrupting the HIV-1 Nef:AP-2alpha interaction limits Nef-mediated apoptosis. PMID: 28577469
    3. These results lead to a model for the docking of the full AP-2 tetramer to membranes as bound to Nef, such that the cytosolic tail of CD4 is situated to interact with its binding site on Nef. PMID: 24473078
    4. A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration. PMID: 22360420
    5. AP2alpha negatively regulates HIV-1 replication in the process of nuclear translocation of viral DNA in the cytoplasm or the perinuclear region. PMID: 18178234
    6. nef usurps AP-2 complexes to dysregulate Ii (invariant chain (Ii)/major histocompatibility complex class II) trafficking and potentially interfere with antigen presentation in the context of MHC-II PMID: 18524831

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族:
    Adaptor complexes large subunit family
  • 組織特異性:
    Expressed in the brain (at protein level). Isoform A: Expressed in forebrain, skeletal muscle, spinal cord, cerebellum, salivary gland, heart and colon. Isoform B: Widely expressed in tissues and also in breast cancer and in prostate carcinoma cells.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 561

    OMIM: 601026

    KEGG: hsa:160

    STRING: 9606.ENSP00000351926

    UniGene: Hs.467125



主站蜘蛛池模板: 亚洲国产老鸭窝一区二区三区| 人妻丝袜av中文系列先锋影音 | 青青久在线视观看视| 在线播放真实国产乱子伦| 国产无遮挡免费真人视频在线观看| 国产爆乳成av人在线播放| 乱人伦中文字幕成人网站在线| 久久99国产精一区二区三区| 亚洲最新无码成av人| 日日日日做夜夜夜夜做无码 | 熟女少妇内射日韩亚洲| 国内精品久久久久影院嫩草| 午夜在线看的免费网站| 粗大的内捧猛烈进出看视频| 欧洲无码一区二区三区在线观看| 国产欧美在线观看不卡| 中文字幕日韩精品一区二区三区 | 亚洲综合久久精品无码色欲| 人人妻人人妻人人人人妻人人| 欧美牲交a欧美牲交aⅴ免费| 亚洲精品国产一区二区| 日本丰满熟妇videossex| 伊人色综合网久久天天| 国产精华av午夜在线| 国产成人艳妇aa视频在线| 久久综合丝袜日本网| 亚洲国产剧情中文视频在线| 好了av第四综合无码久久| 国产精品白丝喷水在线观看| 少妇的肉体k8经典| 97久久婷婷五月综合色d啪蜜芽| 国产黄在线观看免费观看软件| 国产精品三级在线观看无码| 波多野结衣中文字幕久久| 丰满日韩放荡少妇无码视频| 久久精品中文字幕第一页| 大胆欧美熟妇xxbbwwbw高潮了| 国产区图片区小说区亚洲区 | 亚洲阿v天堂在线| 国内熟妇人妻色在线视频| 噜噜高清欧美内射短视频|