在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

AP2A1 Antibody

  • 中文名稱:
    AP2A1兔多克隆抗體
  • 貨號:
    CSB-PA001869GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    100 kDa coated vesicle protein A antibody; Adapter-related protein complex 2 alpha-1 subunit antibody; adapter-related protein complex 2 subunit alpha-1 antibody; Adaptin alpha A antibody; Adaptin alpha antibody; Adaptor protein complex AP 2 alpha 1 subunit antibody; adaptor protein complex AP 2 subunit alpha 1 antibody; Adaptor protein complex AP-2 subunit alpha-1 antibody; Adaptor protein complex AP2 alpha 1 subunit antibody; adaptor protein complex AP2 subunit alpha 1 antibody; Adaptor related protein complex 2 alpha 1 subunit antibody; Adaptor related protein complex AP 2 alpha 1 subunit antibody; Adaptor related protein complex AP2 alpha 1 subunit antibody; ADTAA antibody; Alpha A adaptin antibody; Alpha adaptin A antibody; Alpha-adaptin A antibody; alpha1 adaptin antibody; Alpha1-adaptin antibody; AP 2 alpha antibody; AP 2 complex subunit alpha 1 antibody; AP-2 complex subunit alpha-1 antibody; AP2 complex subunit alpha 1 antibody; AP2-ALPHA antibody; Ap2a1 antibody; AP2A1_HUMAN antibody; CLAPA 1 antibody; CLAPA1 antibody; Clathrin adaptor complex AP2. alpha subunit antibody; Clathrin assembly protein complex 2 alpha A large chain antibody; Clathrin assembly protein complex 2 alpha-A large chain antibody; Clathrin associated / assembly / adaptor protein large alpha 1 antibody; clathrin associated assembly adaptor protein large alpha 1 antibody; clathrin associated/assembly/adaptor protein, large, alpha 1 antibody; Plasma membrane adaptor HA 2/AP 2 adaptin alpha A subunit antibody; Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human AP2A1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif.
  • 基因功能參考文獻:
    1. Results revealed thirteen novel splice junctions of previously annotated exons. Consecutive nested PCRs led to the determination of the primary structure of seventy-seven novel AP2A1 transcripts, all of which were shown to comprise at least one premature translation termination codon, thus representing nonsense-mediated mRNA decay candidates. PMID: 30081190
    2. AP-2alpha depletion enhanced apoptosis, demonstrating that disrupting the HIV-1 Nef:AP-2alpha interaction limits Nef-mediated apoptosis. PMID: 28577469
    3. These results lead to a model for the docking of the full AP-2 tetramer to membranes as bound to Nef, such that the cytosolic tail of CD4 is situated to interact with its binding site on Nef. PMID: 24473078
    4. A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration. PMID: 22360420
    5. AP2alpha negatively regulates HIV-1 replication in the process of nuclear translocation of viral DNA in the cytoplasm or the perinuclear region. PMID: 18178234
    6. nef usurps AP-2 complexes to dysregulate Ii (invariant chain (Ii)/major histocompatibility complex class II) trafficking and potentially interfere with antigen presentation in the context of MHC-II PMID: 18524831

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族:
    Adaptor complexes large subunit family
  • 組織特異性:
    Expressed in the brain (at protein level). Isoform A: Expressed in forebrain, skeletal muscle, spinal cord, cerebellum, salivary gland, heart and colon. Isoform B: Widely expressed in tissues and also in breast cancer and in prostate carcinoma cells.
  • 數據庫鏈接:

    HGNC: 561

    OMIM: 601026

    KEGG: hsa:160

    STRING: 9606.ENSP00000351926

    UniGene: Hs.467125



主站蜘蛛池模板: 色婷婷五月综合欧美图片| 久久国产36精品色熟妇| 日韩精品久久久久久免费| 欧美人与动性xxxxx杂性| 欧美成人一区二免费视频| 青青青国产在线观看资源| 无码人妻少妇精品无码专区漫画| 亚洲成a人v欧美综合天堂| 亚洲精品一区二区三区蜜臀| 色又黄又爽18禁免费视频| 国产成人一区二区三区免费视频| 伊人久久大香线蕉综合75| 人妻熟女αⅴ一区二区三区| 国内精品美女视频免费直播| 特级毛片全部免费播放| 欧美牲交a欧美牲交aⅴ免费| 一本色道无码不卡在线观看| 极品尤物被啪到呻吟喷水| 成人国产片视频在线观看| 国产成人精品一区二区秒播| 国产伦孑沙发午休精品| 国产成人精品综合久久久久| 五月丁香啪啪激情综合色九色| 亚洲国产精品无码久久sm| 欧美人妻aⅴ中文字幕| 精产国品一二三产区蘑菇视频| 国产精品一区在线蜜臀| 中文毛片无遮挡高潮免费| 色先锋av影音先锋在线| 99久久精品免费看国产一区二区| 精品人妻系列无码专区| 人妻巨大乳hd免费看| 影音先锋在线资源无码| 亚洲成av人片天堂网久久| 亚洲综合久久一本久道| 国产特级毛片aaaaaa毛片| 女性自慰网站免费看ww| 亚洲国产成人一区二区三区| 无码人妻精品一区二区三区在线| 97成人精品国语自产拍| 国产亚洲精品a久久777777|