在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. AOX1 Antibody

AOX1 Antibody

  • 中文名稱：
    AOX1兔多克隆抗體
  • 貨號：
    CSB-PA001858GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    AOX1 antibody; AOAldehyde oxidase antibody; EC 1.2.3.1 antibody; Aldehyde oxidase 1 antibody; Azaheterocycle hydroxylase antibody; EC 1.17.3.- antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human AOX1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis.
  • 基因功能參考文獻：
    1. AOX1 SNPs exist in which the base-pair exchange of the SNP leads to loss of enzyme activity. PMID: 26842593
    2. ten novel single nucleotide polymorphisms resulting in amino acid exchanges in proximity to the FAD site of hAOX1, were characterized. PMID: 28750088
    3. Data suggest that substrate specificity of AOX1 includes GDC-0834, an inhibitor of Bruton's tyrosine kinase with potential non-steroidal anti-inflammatory agent activity; in liver cytosol, hydrolysis of GDC-0834 is primarily due to AOX1. PMID: 25845827
    4. Methotrexate is poorly metabolized by human AOX1, in contrast to rabbit. PMID: 26032640
    5. These results supported the possibility that XO/XD and AO can contribute to nitric oxide generation. PMID: 25537183
    6. Several donors have a normal AOX1 protein level. PMID: 23857892
    7. High AOX1 methylation was associated with biochemical recurrence in prostate cancer. PMID: 23918943
    8. The physiological role of AOX1 remains unclear, but it is known that thiopurines belong to its substrates; AOX1 contributes to azathioprine catabolism. PMID: 22495427
    9. hydralazine, at a concentration of 25 to 50 muM, can be used in human hepatocyte incubations to estimate the contribution of aldehyde oxidase to the hepatic clearance of drugs and other compounds. PMID: 22522748
    10. Human population is characterized by the presence of functionally inactive hAOX1 allelic variants as well as variants encoding enzymes with different catalytic activities. PMID: 22279051
    11. characterization of AO activity in cryopreserved human hepatocytes: enzyme stability; substrate specificity; kinetics; inhibition by hydralazine PMID: 22031625
    12. Expressed AOX1 in Escherichia coli and purified kinetically active protein. PMID: 19741035

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Xanthine dehydrogenase family
  • 組織特異性：
    Abundant in liver, expressed in adipose tissue and at lower levels in lung, skeletal muscle, pancreas. In contrast to mice, no significant gender difference in AOX1 expression level (at protein level).
  • 數據庫鏈接：

    HGNC: 553

    OMIM: 602841

    KEGG: hsa:316

    STRING: 9606.ENSP00000363832

    UniGene: Hs.406238



主站蜘蛛池模板： 亚洲午夜福利精品无码不卡| 亚洲欧洲日产韩国在线看片| 亚洲日韩va在线视频| 国产福利免费视频不卡| 夜夜夜夜猛噜噜噜噜噜| 自拍性旺盛老熟女| 女的被弄到高潮娇喘喷水视频| 亚洲色自偷自拍另类小说| 欧美婷婷六月丁香综合| 久久久久av无码免费网| 秋霞午夜成人久久电影网| _97夜夜澡人人爽人人喊_欧美| 国产97色在线 | 日| 人妻换人妻a片爽麻豆| 特级av毛片免费观看| 久久精品66免费99精品| 精品一区二区成人精品| 精品人妻无码一区二区色欲产成人| 国产成人精品三上悠亚| 亚洲va天堂va欧美ⅴa在线| 日本丰满护士videossexhd| 精品久久久久久| 免费观看性行为视频的网站| 天堂在线最新版www中文| 国产v在线在线观看视频免费 | 2021自拍偷在线精品自拍偷| 欧美成人片在线观看| 久久人妻无码中文字幕| 99r在线精品视频在线播放| 日本在线视频www色| 亚洲熟熟妇xxxx| 亚洲熟妇av午夜无码不卡| av天堂午夜精品蜜臀av| 欧美成年视频在线观看| 国产精品进线69影院| 亚洲中文字幕乱码熟女在线| 无套中出丰满人妻无码| 免费无码va一区二区三区| 欧洲一卡2卡3卡4卡国产| 日韩乱码人妻无码中文视频| 成人无码一区二区三区|