在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ALX4 Antibody

  • 中文名稱:
    ALX4兔多克隆抗體
  • 貨號:
    CSB-PA884437LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Western Blot
      Positive WB detected in: Rat liver tissue
      All lanes: ALX4 antibody at 4.2μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 45 kDa
      Observed band size: 45 kDa
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) ALX4 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    ALX4
  • 別名:
    Alx4 antibody; ALX4_HUMAN antibody; Aristaless like homeobox 4 antibody; CRS5 antibody; FND2 antibody; FPP antibody; homeobox protein aristaless like 4 antibody; Homeobox protein aristaless-like 4 antibody; homeodomain transcription factor ALX4 antibody; KIAA1788 antibody; PFM1 antibody; PFM2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human, Rat
  • 免疫原:
    Recombinant Human Homeobox protein aristaless-like 4 protein (112-216AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,ALX4 Antibody (CSB-PA884437LA01HU),的標記方式是Non-conjugated。對于ALX4 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA884437LB01HU ALX4 Antibody, HRP conjugated ELISA
    FITC CSB-PA884437LC01HU ALX4 Antibody, FITC conjugated
    Biotin CSB-PA884437LD01HU ALX4 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcription factor involved in skull and limb development. Plays an essential role in craniofacial development, skin and hair follicle development.
  • 基因功能參考文獻:
    1. We reveal for the first time that ALX4 acts as a novel functional tumor suppressor inactivated by DNA methylation and is an independent prognostic factor in breast cancer PMID: 29183346
    2. overexpression of ALX4 inhibited the proliferation, invasion, and epithelial-mesenchymal transition (EMT) in HCC cells. ALX4 had an inhibitory effect on the sonic hedgehog (Shh) signaling pathway. PMID: 28081728
    3. mother of Case 2 also had a mutation in the ALX4 gene, but no enlarged parietal foramina PMID: 27349084
    4. Our results show that HOXB13/SLUG and ALX4/SLUG axes are novel pathways that promote EMT and invasion of ovarian cancer cells. PMID: 25944620
    5. High-quality solution NMR structures of three homeodomains from human proteins ALX4, ZHX1 and CASP8AP2 were solved. PMID: 24941917
    6. We suggest that all ALX4 heterozygote carriers be examined in detail for possible changes in nasal configuration, to establish a detailed genotype-phenotype correlation, leading the way to more comprehensive genetic counseling. PMID: 24764194
    7. Epigenetic silencing of Aristaless-like homeobox-4 is associated with lung cancer. PMID: 24037716
    8. study describes 2 related individuals with a heterozygous mutation in ALX4 presenting a distinct phenotype of frontonasal dysplasia; suggest that the loss of the ALX4 OAR domain with the maintenance of the homeodomain impairs the function of the normal allele in a dominant-negative effect PMID: 23401352
    9. ALX4 variants may have an impact on the genetic etiology of nonsyndromic craniosynostosis. PMID: 22829454
    10. Exclusion of mutations in ALX4 gene in patients with the syndrome of frontonasal dysgenesis, callosal agenesis, basal encephalocele, and eye anomalies PMID: 22496059
    11. Downregulation of HoxB2, HoxB4 and Alx4 expression during the narrow window of early embryogenesis may cause omphalocele in the Cd chick model by interfering with molecular signaling required for proper VBW formation. PMID: 20625746
    12. Data show that methylated DNA from advanced precancerous colorectal lesions can be detected using a panel of two DNA methylation markers, ALX4 and SEPT9. PMID: 20140221
    13. data show a distinct pattern of expression of ALX4 in the human breast relative to the murine mammary gland, and the loss of ALX4 in tumours and the surrounding untransformed stroma is a basic characteristic of ductal carcinoma. PMID: 19783719
    14. ALX4 plays a critical role in craniofacial and epidermal development. PMID: 19692347
    15. One subject with parietal foramina whose deletion does not include ALX4 indicates that ALX4 in this subject may be rendered functionally haploinsufficient by a position effect. PMID: 15852040
    16. The ALX4 mutation p.R218Q tends to result in persistent cranium bifidum and is associated with anatomical abnormalities of the posterior fossa. PMID: 16319823

    顯示更多

    收起更多

  • 相關疾病:
    Parietal foramina 2 (PFM2); Frontonasal dysplasia 2 (FND2); Potocki-Shaffer syndrome (POSHS); Craniosynostosis 5 (CRS5)
  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    Paired homeobox family
  • 組織特異性:
    Expression is likely to be restricted to bone. Found in parietal bone.
  • 數據庫鏈接:

    HGNC: 450

    OMIM: 601224

    KEGG: hsa:60529

    STRING: 9606.ENSP00000332744

    UniGene: Hs.436055



主站蜘蛛池模板: 国内精品久久久久影院优| 国产欧美日韩国产高清| 秋霞电影网午夜鲁丝片无码| 52综合精品国产二区无码| 色欲综合一区二区三区| 亚洲阿v天堂在线| 国产成人 综合 亚洲欧洲| 成人无码精品免费视频在线观看| 国产精品高清网站| 亚洲欧美中文日韩在线v日本| 国内精品九九久久久精品| 亚洲精品无码精品mv在线观看| 少妇精品无码一区二区免费视频| 国精产品一区一区三区有限公司杨| 亚洲性人人天天夜夜摸| 欧美成人高清视频a在线看| 好吊色欧美一区二区三区四区| 波多野结衣的av一区二区三区| 久久久久久99av无码免费网站| 国产婷婷综合在线视频| 特级精品毛片免费观看| 中文字幕无码毛片免费看| 精品免费国产一区二区| 男女啪啪永久免费网站| 成熟了的熟妇毛茸茸| 狠狠精品久久久无码中文字幕 | 日韩精品一区二区三区| 无码一区二区三区av免费 | 精品精品国产欧美在线小说区| 国产精品一区二区久久不卡| 国产精品无码无在线观看| 麻豆视传媒精品av| 男女啪啪网站大全免费| 久久国产精品二国产精品 | 日韩欧美亚洲综合久久影院| 在线播放五十路熟妇| 无码吃奶揉捏奶头高潮视频| 亚洲图片小说激情综合| 国产成人精品一区二区三区视频 | 国产精品久久久久久吹潮| 看成年全黄大色黄大片|