在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ALX4 Antibody, FITC conjugated

  • 中文名稱:
    ALX4兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA884437LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) ALX4 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    ALX4
  • 別名:
    Alx4 antibody; ALX4_HUMAN antibody; Aristaless like homeobox 4 antibody; CRS5 antibody; FND2 antibody; FPP antibody; homeobox protein aristaless like 4 antibody; Homeobox protein aristaless-like 4 antibody; homeodomain transcription factor ALX4 antibody; KIAA1788 antibody; PFM1 antibody; PFM2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Homeobox protein aristaless-like 4 protein (112-216AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcription factor involved in skull and limb development. Plays an essential role in craniofacial development, skin and hair follicle development.
  • 基因功能參考文獻:
    1. We reveal for the first time that ALX4 acts as a novel functional tumor suppressor inactivated by DNA methylation and is an independent prognostic factor in breast cancer PMID: 29183346
    2. overexpression of ALX4 inhibited the proliferation, invasion, and epithelial-mesenchymal transition (EMT) in HCC cells. ALX4 had an inhibitory effect on the sonic hedgehog (Shh) signaling pathway. PMID: 28081728
    3. mother of Case 2 also had a mutation in the ALX4 gene, but no enlarged parietal foramina PMID: 27349084
    4. Our results show that HOXB13/SLUG and ALX4/SLUG axes are novel pathways that promote EMT and invasion of ovarian cancer cells. PMID: 25944620
    5. High-quality solution NMR structures of three homeodomains from human proteins ALX4, ZHX1 and CASP8AP2 were solved. PMID: 24941917
    6. We suggest that all ALX4 heterozygote carriers be examined in detail for possible changes in nasal configuration, to establish a detailed genotype-phenotype correlation, leading the way to more comprehensive genetic counseling. PMID: 24764194
    7. Epigenetic silencing of Aristaless-like homeobox-4 is associated with lung cancer. PMID: 24037716
    8. study describes 2 related individuals with a heterozygous mutation in ALX4 presenting a distinct phenotype of frontonasal dysplasia; suggest that the loss of the ALX4 OAR domain with the maintenance of the homeodomain impairs the function of the normal allele in a dominant-negative effect PMID: 23401352
    9. ALX4 variants may have an impact on the genetic etiology of nonsyndromic craniosynostosis. PMID: 22829454
    10. Exclusion of mutations in ALX4 gene in patients with the syndrome of frontonasal dysgenesis, callosal agenesis, basal encephalocele, and eye anomalies PMID: 22496059
    11. Downregulation of HoxB2, HoxB4 and Alx4 expression during the narrow window of early embryogenesis may cause omphalocele in the Cd chick model by interfering with molecular signaling required for proper VBW formation. PMID: 20625746
    12. Data show that methylated DNA from advanced precancerous colorectal lesions can be detected using a panel of two DNA methylation markers, ALX4 and SEPT9. PMID: 20140221
    13. data show a distinct pattern of expression of ALX4 in the human breast relative to the murine mammary gland, and the loss of ALX4 in tumours and the surrounding untransformed stroma is a basic characteristic of ductal carcinoma. PMID: 19783719
    14. ALX4 plays a critical role in craniofacial and epidermal development. PMID: 19692347
    15. One subject with parietal foramina whose deletion does not include ALX4 indicates that ALX4 in this subject may be rendered functionally haploinsufficient by a position effect. PMID: 15852040
    16. The ALX4 mutation p.R218Q tends to result in persistent cranium bifidum and is associated with anatomical abnormalities of the posterior fossa. PMID: 16319823

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Parietal foramina 2 (PFM2); Frontonasal dysplasia 2 (FND2); Potocki-Shaffer syndrome (POSHS); Craniosynostosis 5 (CRS5)
  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    Paired homeobox family
  • 組織特異性:
    Expression is likely to be restricted to bone. Found in parietal bone.
  • 數據庫鏈接:

    HGNC: 450

    OMIM: 601224

    KEGG: hsa:60529

    STRING: 9606.ENSP00000332744

    UniGene: Hs.436055



主站蜘蛛池模板: 影音先锋无码a∨男人资源站| 国产思思99re99在线观看| 国产av国片偷人妻麻豆| 久久精品国产亚洲欧美| 国产日韩综合一区二区性色av| 国产精品成人亚洲777| 少妇被粗大的猛烈进出动视频| 国产又粗又猛又爽又黄的视频在线观看动漫 | 国产精品高潮呻吟av久久男男| 欧美多毛肥胖老妇做爰| 欧美性大战久久久久久| 人妻熟女一区二区aⅴ图片| 国产福利一区二区麻豆| 午夜福利无码不卡在线观看| 97久久香蕉国产线看观看| 国产精品自在自线视频| 国产精品玖玖玖在线| 国产午夜亚洲精品午夜鲁丝片| 日韩免费特黄一二三区| 永久久久免费人妻精品| 99精品国产福久久久久久| 又爽又黄又无遮挡的视频| 无码国模国产在线观看免费 | 亚洲国产码专区| 乱人伦人妻精品一区二区| 少妇高清精品毛片在线视频| 四虎影视884a精品国产| 老头把我添高潮了a片| 欧美色综合天天久久综合精品| 肉大榛一进一出免费视频| 亚洲亚洲人成无码网www| 少妇私密推油呻吟在线播放| √最新版天堂资源网在线| 麻豆蜜桃av蜜臀av色欲av| 日本一道高清一区二区三区| 未满小14洗澡无码视频网站 | 欧美xxxx精品另类| 日本一区二区a√成人片| 蜜臀av999无码精品国产专区| 亚洲中文字幕无码中文字在线| 一本一道波多野结衣一区|