在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ALKBH2 Antibody

ALKBH2 Antibody

  • 中文名稱：
    ALKBH2兔多克隆抗體
  • 貨號(hào)：
    CSB-PA259131
  • 規(guī)格：
    ￥1100
  • 圖片：
    • Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Human fetal liver tissue, Human seminoma tissue, RAW264.7 cells, Primary antibody: CSB-PA259131(ALKBH2 Antibody) at dilution 1/650, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    ALKBH2
  • 別名：
    2OG Fe(II) oxy DC1 antibody; 9530023G02 antibody; ABH 2 antibody; ABH2 antibody; alkB alkylation repair homolog 2 antibody; ALKB2_HUMAN antibody; ALKBH2 alkB antibody; ALKBH2 antibody; Alkylated DNA repair protein alkB homolog antibody; Alkylated DNA repair protein alkB homolog 2 antibody; Alkylation repair homolog 2 antibody; Alpha ketoglutarate dependent dioxygenase alkB homolog 2 antibody; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 antibody; AU016977 antibody; DNA oxidative demethylase ALKBH2 antibody; EC 1.14.11. antibody; FLJ99103 antibody; hABH2 antibody; mABH2 antibody; MGC90512 antibody; Oxy DC1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human ALKBH2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.
  • 基因功能參考文獻(xiàn)：
    1. These results revealed that N3-ethylthymidine , but not other DNA lesions, could be repaired by Alkbh2 and Alkbh3 in mammalian cells. PMID: 26930515
    2. studies reveal the ALKBH2 binding interface of PCNA and indicate that both germline and somatic ALKBH2 variants could have cellular effects on ALKBH2 function in DNA repair. PMID: 26408825
    3. It was shown for first time that DNA glycosylase ALKBH2 can repair DNA adduct 1,N2-ethenoguanine. PMID: 25797601
    4. ABH2 knockdown impairs rDNA transcription and leads to increased single-stranded and double-stranded DNA breaks in the rDNA genes. PMID: 23972994
    5. Overexpression of ALKBH2 is associated with enhanced resistance to temozolomide in glioblastoma. PMID: 23258843
    6. ALKBH2 is an upstream molecule of the oncoprotein, MUC1, and regulates cell cycle and EMT, resulting in progression of urothelial carcinomas. PMID: 23279696
    7. combination of duplex interrogation and oxidation chemistry allows ALKBH2 to detect and process diverse lesions efficiently and correctly PMID: 22659876
    8. The non-enzymatic binding of AAG to 3,N(4)-ethenocytosine specifically blocks ALKBH2-catalyzed repair of 3,N(4)-ethenocytosine but not that of methylated ALKBH2 substrates. PMID: 22079122
    9. X-ray absorption spectroscopy structural investigation of early intermediates in the mechanism of DNA repair by human ABH2 PMID: 21510633
    10. ABH2 is downregulated in a subset of gastric cancers, and might be involved in the molecular mechanism of gastric cancer through inhibiting the proliferation of gastric cancer cells. PMID: 21155885
    11. This work has provided a detailed understanding of the structural features of the single-stranded DNA and double-stranded DNA preferences of ABH2 and ABH3. PMID: 20714506
    12. Divergent sequences outside of the active site determine substrate specificities of ABH2. PMID: 20525795
    13. Tumour protein (TP53) is directly involved by binding to the promoter of ALKBH2 in mediating photofrin-mediaated photodynamic therapy in U87 glioma cells. PMID: 20661249
    14. first crystal structure of ABH2 PMID: 18432238
    15. ABH2 is active in the direct reversal of epsilon A lesions, and that ABH2, together with the alkyl-N-adenine-DNA glycosylase, which is the most effective enzyme for the repair of epsilon A, comprise the cellular defense against epsilon A lesions PMID: 18519673
    16. Mutations of ABH2 is associated with pediatric brain tumors. PMID: 19290481

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Nucleus. Note=Detected in replication foci during S-phase.
  • 蛋白家族：
    AlkB family
  • 組織特異性：
    Detected in colon, small intestine, ovary, testis, prostate, skeletal muscle, heart, liver and urinary bladder.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 32487

    OMIM: 610602

    KEGG: hsa:121642

    STRING: 9606.ENSP00000343021

    UniGene: Hs.374458



主站蜘蛛池模板： 性男女做视频观看网站| 天天躁日日躁狠狠躁超碰97| 免费看成人aa片无码视频羞羞网| 夜爽8888视频在线观看| 亚洲日产av中文字幕无码偷拍| 日本老熟妇乱子伦视频| 国产微拍精品一区二区| 国产sm调教折磨视频| 亚洲成h人av无码动漫无遮挡| 欧美成人精品 一区二区三区| 最新国产av无码专区亚洲| 巨爆乳中文字幕爆乳区| 亚洲国产成人久久综合碰| 亚洲 欧美 清纯 校园 另类 | 国产精品久久久天天影视香蕉| 国产精品无码无片在线观看| 无码人妻久久一区二区三区蜜桃| 天无日天天射天天视| 精品久久久久久久国产潘金莲| 国产精品久久久久久av| 国产精品香蕉在线的人| 一道精品视频一区二区三区| 久久精品aⅴ无码中文字字幕| 欧美成人精品三级网站| 亚洲人成在线观看网站不卡| 精品午夜中文字幕熟女人妻在线 | 国产人妻aⅴ色偷| 日韩高清成片免费视频| 午夜一区二区亚洲福利| 亚洲视频在线观看| 精品国产无套在线观看| 特级毛片全部免费播放| 亚洲人亚洲人成电影网站色| 女人被狂躁c到高潮喷水一区二区| 欧亚精品一区三区免费| 亚洲人成网站18禁止| 在线成人一区二区| 久久国产欧美日韩精品图片| 成人啪精品视频网站午夜| 亚洲一区二区| 国产精品久久久天天影视|