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ALKBH2 Antibody

  • 中文名稱:
    ALKBH2兔多克隆抗體
  • 貨號:
    CSB-PA761219ESR2HU
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 antibody at 2μg/ml + Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 30, 18 kDa
      Observed band size: 30 kDa
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA761219ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA761219ESR2HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) ALKBH2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    ALKBH2
  • 別名:
    2OG Fe(II) oxy DC1 antibody; 9530023G02 antibody; ABH 2 antibody; ABH2 antibody; alkB alkylation repair homolog 2 antibody; ALKB2_HUMAN antibody; ALKBH2 alkB antibody; ALKBH2 antibody; Alkylated DNA repair protein alkB homolog antibody; Alkylated DNA repair protein alkB homolog 2 antibody; Alkylation repair homolog 2 antibody; Alpha ketoglutarate dependent dioxygenase alkB homolog 2 antibody; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 antibody; AU016977 antibody; DNA oxidative demethylase ALKBH2 antibody; EC 1.14.11. antibody; FLJ99103 antibody; hABH2 antibody; mABH2 antibody; MGC90512 antibody; Oxy DC1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human DNA oxidative demethylase ALKBH2 protein (1-261AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:200-1:1000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.
  • 基因功能參考文獻:
    1. These results revealed that N3-ethylthymidine , but not other DNA lesions, could be repaired by Alkbh2 and Alkbh3 in mammalian cells. PMID: 26930515
    2. studies reveal the ALKBH2 binding interface of PCNA and indicate that both germline and somatic ALKBH2 variants could have cellular effects on ALKBH2 function in DNA repair. PMID: 26408825
    3. It was shown for first time that DNA glycosylase ALKBH2 can repair DNA adduct 1,N2-ethenoguanine. PMID: 25797601
    4. ABH2 knockdown impairs rDNA transcription and leads to increased single-stranded and double-stranded DNA breaks in the rDNA genes. PMID: 23972994
    5. Overexpression of ALKBH2 is associated with enhanced resistance to temozolomide in glioblastoma. PMID: 23258843
    6. ALKBH2 is an upstream molecule of the oncoprotein, MUC1, and regulates cell cycle and EMT, resulting in progression of urothelial carcinomas. PMID: 23279696
    7. combination of duplex interrogation and oxidation chemistry allows ALKBH2 to detect and process diverse lesions efficiently and correctly PMID: 22659876
    8. The non-enzymatic binding of AAG to 3,N(4)-ethenocytosine specifically blocks ALKBH2-catalyzed repair of 3,N(4)-ethenocytosine but not that of methylated ALKBH2 substrates. PMID: 22079122
    9. X-ray absorption spectroscopy structural investigation of early intermediates in the mechanism of DNA repair by human ABH2 PMID: 21510633
    10. ABH2 is downregulated in a subset of gastric cancers, and might be involved in the molecular mechanism of gastric cancer through inhibiting the proliferation of gastric cancer cells. PMID: 21155885
    11. This work has provided a detailed understanding of the structural features of the single-stranded DNA and double-stranded DNA preferences of ABH2 and ABH3. PMID: 20714506
    12. Divergent sequences outside of the active site determine substrate specificities of ABH2. PMID: 20525795
    13. Tumour protein (TP53) is directly involved by binding to the promoter of ALKBH2 in mediating photofrin-mediaated photodynamic therapy in U87 glioma cells. PMID: 20661249
    14. first crystal structure of ABH2 PMID: 18432238
    15. ABH2 is active in the direct reversal of epsilon A lesions, and that ABH2, together with the alkyl-N-adenine-DNA glycosylase, which is the most effective enzyme for the repair of epsilon A, comprise the cellular defense against epsilon A lesions PMID: 18519673
    16. Mutations of ABH2 is associated with pediatric brain tumors. PMID: 19290481

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  • 亞細胞定位:
    Nucleus. Note=Detected in replication foci during S-phase.
  • 蛋白家族:
    AlkB family
  • 組織特異性:
    Detected in colon, small intestine, ovary, testis, prostate, skeletal muscle, heart, liver and urinary bladder.
  • 數據庫鏈接:

    HGNC: 32487

    OMIM: 610602

    KEGG: hsa:121642

    STRING: 9606.ENSP00000343021

    UniGene: Hs.374458



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