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ALDOA Antibody

  • 中文名稱:
    ALDOA兔多克隆抗體
  • 貨號:
    CSB-PA000862
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of COLO205 cells using Aldolase A Polyclonal Antibody
    • Western Blot analysis of NIH-3T3 K562 cells using Aldolase A Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    ALDA antibody; Aldo1 antibody; ALDOA antibody; ALDOA_HUMAN antibody; Aldolase 1 antibody; Aldolase A antibody; Aldolase A fructose bisphosphatase antibody; Aldolase A fructose bisphosphate antibody; Aldolase; fructose-bisphosphate A antibody; Epididymis secretory sperm binding protein Li 87p antibody; FRUCTOALDOLASE A antibody; Fructose 1 6 bisphosphate triosephosphate lyase antibody; Fructose bisphosphate aldolase A antibody; Fructose bisphosphate aldolase antibody; FRUCTOSE-1,6-BISPHOSPHATE ALDOLASE A antibody; Fructose-bisphosphate aldolase A antibody; Fructose-bisphosphate aldolase A Muscle-type antibody; GSD12 antibody; HEL S 87p antibody; Lung cancer antigen NY LU 1 antibody; Lung cancer antigen NY-LU-1 antibody; MGC10942 antibody; MGC17716 antibody; MGC17767 antibody; Muscle type aldolase antibody; Muscle-type aldolase antibody; RNALDOG5 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the N-terminal region of Human Aldolase A.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:200-1:1000
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein.
  • 基因功能參考文獻:
    1. Results showed that ALDOA was upregulated in renal cell carcinoma (RCC) samples and cell lines and significantly associated with metastasis and survival. Overall, data revealed that ALDOA functions as a tumor promoter, plays a prominent role in proliferation, migration, and invasion of RCC cells with high expression, and may promote EMT and activate the Wnt/betacatenin signaling pathway. PMID: 29693182
    2. The results indicate that ALDOA and PGK1 may indicate resistance to cisplatin in osteosarcoma PMID: 29199648
    3. Knockdown of ALDOA in QBC939 and RBE cells attenuated the cell proliferation and induced a higher apoptosis rate. PMID: 30121648
    4. Silencing aldolase A suppressed colon cancer cell proliferation and invasion and inhibited the epithelial-mesenchymal transition phenotype. Aldolase A protein expression in colon cancer was related to tumor location, tumor clinical stage and survival. PMID: 29453983
    5. mir-122 and its targets G6PC3, ALDOA and CS play roles in the hypoxia responses that regulate glucose and energy metabolism and can serve as hypoxia biomarkers. PMID: 27793029
    6. Aldolase A promotes lung cancer metastasis via PHD-mediated stabilization of HIF-1alpha and the subsequent activation of MMP9. PMID: 28610954
    7. Findings show that ALDOA expression is up-regulated in colorectal cancer (CRC) and is a hypoxia-inducible prognostic factor that is closely related to CRC malignancy. PMID: 28000858
    8. Overexpression of ALDOA is associated with colorectal cancer. PMID: 27468721
    9. In vitro and in vivo results demonstrated that ALDOA was associated with proliferation and metastasis of pancreatic cancer cells. PMID: 26854714
    10. Study shows that PI3K directly coordinates glycolysis with cytoskeletal dynamics in an AKT-independent manner. Growth factors or insulin stimulate the PI3K-dependent activation of Rac, leading to disruption of the actin cytoskeleton, release of filamentous actin-bound aldolase A, and an increase in aldolase activity. PMID: 26824656
    11. Our results expand the clinical spectrum of aldolase A deficiency to isolated temperature-dependent rhabdomyolysis, and suggest that thermolability may be tissue specific. We also propose a treatment for this severe disease PMID: 25392908
    12. Study provides evidence supporting a critical functional role of ALDOA in osteosarcoma progression, metastasis and perhaps chemoresistance. PMID: 25215901
    13. ALDOC, Aldolase A (ALDOA) and Aldolase B (ALDOB) activate Wnt signaling. PMID: 24993527
    14. ALDOA is highly expressed in lung squamous cell carcinoma (LSCC) and its expression level is correlated with LSCC metastasis, grades, differentiation status and poor prognosis. PMID: 24465716
    15. The expression of ALDOA and/or SULT1A3 is significantly higher. PMID: 22949271
    16. The results presented here point to ALDA as a factor involved in the regulation of cells proliferation. PMID: 23886627
    17. The new prognostic biomarkers GRP78, Fructose-bisphosphate Aldolase A (ALDOA), Carbonic Anhydrase I (CA1) and Peptidyl-prolyl cis-trans isomerase A or Cyclophilin A (PPIA)) provided good survival prediction for TNM stage I-IV patients. PMID: 22996014
    18. ALDOA is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. PMID: 21555518
    19. Data that aldolase forms a complex with ARNO/Arf6 and the V-ATPase and that it may contribute to remodeling of the actin cytoskeleton. PMID: 21307348
    20. Posttranslational nitration of aldolase A may be an important pathway that regulates mast cell phenotype and function. PMID: 20511553
    21. ALDOA is involved in keratinocyte migration following the induction of lamellipodia formation, and ALDOA-related migration is enhanced by EGF PMID: 20362419
    22. melanoma antigen expressed in G361, a representative melanoma cell line/ reacted with autoantibodies in patient sera PMID: 20181627
    23. Gly346 is crucial for the correct conformation and function of aldolase A, because it governs the entry/release of the substrates into/from the enzyme cleft, and/or allows important C-terminal residues to approach the active site. PMID: 14766013
    24. The existence of highly AMP-sensitive muscle-like FBPase, activity of which is regulated by metabolite-dependent interaction with aldolase enables the precise regulation of muscle energy expenditures. PMID: 18214967
    25. Results identify VDAC2 and aldolase A as membrane proteins of K562 cells with increased expression under iron deprivation. PMID: 18278581
    26. Aldolase A may play a role in the radio-response of human cells, probably in nuclei, in addition to its glycolytic role in the cytosol. PMID: 18328256
    27. ZNF224 recruits the arginine methyltransferase PRMT5 on the transcriptional repressor complex of the aldolase A gene PMID: 19741270

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  • 相關疾病:
    Glycogen storage disease 12 (GSD12)
  • 亞細胞定位:
    Cytoplasm, myofibril, sarcomere, I band. Cytoplasm, myofibril, sarcomere, M line.
  • 蛋白家族:
    Class I fructose-bisphosphate aldolase family
  • 數據庫鏈接:

    HGNC: 414

    OMIM: 103850

    KEGG: hsa:226

    STRING: 9606.ENSP00000336927

    UniGene: Hs.513490



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