在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ALDOA Antibody

  • 中文名稱:
    ALDOA兔多克隆抗體
  • 貨號:
    CSB-PA00015A0Rb
  • 規格:
    ¥440
  • 圖片:
    • Western Blot
      Positive WB detected in: Jurkat whole cell lysate, Rat kidney tissue
      All lanes: ALDOA antibody at 3µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 40, 46 kDa
      Observed band size: 46 kDa
    • IHC image of CSB-PA00015A0Rb diluted at 1:100 and staining in paraffin-embedded human skeletal muscle tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) ALDOA Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    ALDA antibody; Aldo1 antibody; ALDOA antibody; ALDOA_HUMAN antibody; Aldolase 1 antibody; Aldolase A antibody; Aldolase A fructose bisphosphatase antibody; Aldolase A fructose bisphosphate antibody; Aldolase; fructose-bisphosphate A antibody; Epididymis secretory sperm binding protein Li 87p antibody; FRUCTOALDOLASE A antibody; Fructose 1 6 bisphosphate triosephosphate lyase antibody; Fructose bisphosphate aldolase A antibody; Fructose bisphosphate aldolase antibody; FRUCTOSE-1,6-BISPHOSPHATE ALDOLASE A antibody; Fructose-bisphosphate aldolase A antibody; Fructose-bisphosphate aldolase A Muscle-type antibody; GSD12 antibody; HEL S 87p antibody; Lung cancer antigen NY LU 1 antibody; Lung cancer antigen NY-LU-1 antibody; MGC10942 antibody; MGC17716 antibody; MGC17767 antibody; Muscle type aldolase antibody; Muscle-type aldolase antibody; RNALDOG5 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human, Rat
  • 免疫原:
    Recombinant Human Fructose-bisphosphate aldolase A protein (2-364AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,ALDOA Antibody (CSB-PA00015A0Rb),的標記方式是Non-conjugated。對于ALDOA Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA00015B0Rb ALDOA Antibody, HRP conjugated ELISA
    FITC CSB-PA00015C0Rb ALDOA Antibody, FITC conjugated
    Biotin CSB-PA00015D0Rb ALDOA Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein.
  • 基因功能參考文獻:
    1. Results showed that ALDOA was upregulated in renal cell carcinoma (RCC) samples and cell lines and significantly associated with metastasis and survival. Overall, data revealed that ALDOA functions as a tumor promoter, plays a prominent role in proliferation, migration, and invasion of RCC cells with high expression, and may promote EMT and activate the Wnt/betacatenin signaling pathway. PMID: 29693182
    2. The results indicate that ALDOA and PGK1 may indicate resistance to cisplatin in osteosarcoma PMID: 29199648
    3. Knockdown of ALDOA in QBC939 and RBE cells attenuated the cell proliferation and induced a higher apoptosis rate. PMID: 30121648
    4. Silencing aldolase A suppressed colon cancer cell proliferation and invasion and inhibited the epithelial-mesenchymal transition phenotype. Aldolase A protein expression in colon cancer was related to tumor location, tumor clinical stage and survival. PMID: 29453983
    5. mir-122 and its targets G6PC3, ALDOA and CS play roles in the hypoxia responses that regulate glucose and energy metabolism and can serve as hypoxia biomarkers. PMID: 27793029
    6. Aldolase A promotes lung cancer metastasis via PHD-mediated stabilization of HIF-1alpha and the subsequent activation of MMP9. PMID: 28610954
    7. Findings show that ALDOA expression is up-regulated in colorectal cancer (CRC) and is a hypoxia-inducible prognostic factor that is closely related to CRC malignancy. PMID: 28000858
    8. Overexpression of ALDOA is associated with colorectal cancer. PMID: 27468721
    9. In vitro and in vivo results demonstrated that ALDOA was associated with proliferation and metastasis of pancreatic cancer cells. PMID: 26854714
    10. Study shows that PI3K directly coordinates glycolysis with cytoskeletal dynamics in an AKT-independent manner. Growth factors or insulin stimulate the PI3K-dependent activation of Rac, leading to disruption of the actin cytoskeleton, release of filamentous actin-bound aldolase A, and an increase in aldolase activity. PMID: 26824656
    11. Our results expand the clinical spectrum of aldolase A deficiency to isolated temperature-dependent rhabdomyolysis, and suggest that thermolability may be tissue specific. We also propose a treatment for this severe disease PMID: 25392908
    12. Study provides evidence supporting a critical functional role of ALDOA in osteosarcoma progression, metastasis and perhaps chemoresistance. PMID: 25215901
    13. ALDOC, Aldolase A (ALDOA) and Aldolase B (ALDOB) activate Wnt signaling. PMID: 24993527
    14. ALDOA is highly expressed in lung squamous cell carcinoma (LSCC) and its expression level is correlated with LSCC metastasis, grades, differentiation status and poor prognosis. PMID: 24465716
    15. The expression of ALDOA and/or SULT1A3 is significantly higher. PMID: 22949271
    16. The results presented here point to ALDA as a factor involved in the regulation of cells proliferation. PMID: 23886627
    17. The new prognostic biomarkers GRP78, Fructose-bisphosphate Aldolase A (ALDOA), Carbonic Anhydrase I (CA1) and Peptidyl-prolyl cis-trans isomerase A or Cyclophilin A (PPIA)) provided good survival prediction for TNM stage I-IV patients. PMID: 22996014
    18. ALDOA is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. PMID: 21555518
    19. Data that aldolase forms a complex with ARNO/Arf6 and the V-ATPase and that it may contribute to remodeling of the actin cytoskeleton. PMID: 21307348
    20. Posttranslational nitration of aldolase A may be an important pathway that regulates mast cell phenotype and function. PMID: 20511553
    21. ALDOA is involved in keratinocyte migration following the induction of lamellipodia formation, and ALDOA-related migration is enhanced by EGF PMID: 20362419
    22. melanoma antigen expressed in G361, a representative melanoma cell line/ reacted with autoantibodies in patient sera PMID: 20181627
    23. Gly346 is crucial for the correct conformation and function of aldolase A, because it governs the entry/release of the substrates into/from the enzyme cleft, and/or allows important C-terminal residues to approach the active site. PMID: 14766013
    24. The existence of highly AMP-sensitive muscle-like FBPase, activity of which is regulated by metabolite-dependent interaction with aldolase enables the precise regulation of muscle energy expenditures. PMID: 18214967
    25. Results identify VDAC2 and aldolase A as membrane proteins of K562 cells with increased expression under iron deprivation. PMID: 18278581
    26. Aldolase A may play a role in the radio-response of human cells, probably in nuclei, in addition to its glycolytic role in the cytosol. PMID: 18328256
    27. ZNF224 recruits the arginine methyltransferase PRMT5 on the transcriptional repressor complex of the aldolase A gene PMID: 19741270

    顯示更多

    收起更多

  • 相關疾病:
    Glycogen storage disease 12 (GSD12)
  • 亞細胞定位:
    Cytoplasm, myofibril, sarcomere, I band. Cytoplasm, myofibril, sarcomere, M line.
  • 蛋白家族:
    Class I fructose-bisphosphate aldolase family
  • 數據庫鏈接:

    HGNC: 414

    OMIM: 103850

    KEGG: hsa:226

    STRING: 9606.ENSP00000336927

    UniGene: Hs.513490



主站蜘蛛池模板: 中文字字幕在线中文乱码| 欧洲极品少妇| 三级特黄60分钟在线播放| 99久久久国产精品免费蜜臀| 国产一区二区三区| 99精品视频一区在线观看| 国产拍揄自揄免费观看| 精产一二三产区m553| 欧美一区内射最近更新| 丝袜高跟麻麻浓精受孕人妻| 在线观看的av免费网站| 2021亚洲国产成a在线| 色在线 | 国产| 爽爽精品dvd蜜桃成熟时电影院| 伊人色综合久久天天人守人婷| 亚洲国产精品第一区二区三区| 宝贝腿开大点我添添公视频免费| av天堂午夜精品一区| 午夜福利国产成人无码gif动图 | 抽插丰满内射高潮视频| 成人3d动漫一区二区三区| 国产综合视频一区二区三区| 日韩一区二区三区无码人妻视频 | 中文字幕日韩人妻无码| 99久久国产热无码精品免费| 亚洲国产精品不卡av在线| 国产明星裸体xxxx视频| 日本公妇乱偷中文字幕| 成年女人18级毛片毛片免费| 婷婷五月日韩av永久免费| 亚洲精品综合欧美一区二区三区| 裸身美女无遮挡永久免费视频| 中文字幕亚洲乱码熟女在线| 国产精品sm捆绑调教视频| 亚洲丰满熟妇在线播放电影全集| 风间由美性色一区二区三区| 丰满大爆乳波霸奶| 人妻精品久久无码区| 扒开女人内裤猛进猛出免费视频| 日韩久久无码免费毛片软件| 亚洲欧美人高清精品a∨|