在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

AKAP1 Antibody

  • 中文名稱:
    AKAP1兔多克隆抗體
  • 貨號(hào):
    CSB-PA793193
  • 規(guī)格:
    ¥2024
  • 圖片:
    • Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue using at dilution 1/40.
    • Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/40.
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) AKAP1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    AKAP1
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthetic peptide corresponding to a region derived from internal residues of Human A kinase (PRKA) anchor protein 1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類(lèi)型:
    Polyclonal
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:50-1:100
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. Involved in mitochondrial-mediated antiviral innate immunity. Promotes translocation of NDUFS1 into mitochondria to regulate mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) activity.
  • 基因功能參考文獻(xiàn):
    1. AKAP1 is a transcriptional target of Myc, and it supports mTOR pathway and the growth of cancer cells. PMID: 28569781
    2. Furthermore, we discuss the role of hypoxia in prompting cellular stress and damage, which has been demonstrated to mediate the proteosomal degradation of AKAP121, leading to an increase in reactive oxgyen species production, mitochondrial dysfunction, and ultimately cell death. [review] PMID: 26825124
    3. Functional characterization revealed an undescribed role for AMPK-dependent phosphorylation of AKAP1 in mitochondrial respiration. PMID: 26437602
    4. AKAP 149-PKA-PDE4A complex localization is related with YTX effect in K-562 cell line PMID: 24813785
    5. In the case of the beta2AR, this process is facilitated by the presence of A-Kinase Anchoring Proteins (AKAPs) that serve as scaffolding proteins for the L-type calcium channel and the beta2AR complex. PMID: 23557075
    6. AKAP1 anchors Star mRNA at the mitochondria, thus stabilizing the translational complex at this organelle, a situation that might affect STAR production and steroidogenesis. PMID: 23077346
    7. In tumoural lymphocytes, yessotoxin decreases AKAP149 cytosolic expression and increases cAMP levels which leads to cell death. PMID: 22807343
    8. Shp2 is a component of the AKAP-Lbc complex and is inhibited by protein kinase A under pathological hypertrophic conditions in the heart. PMID: 23045525
    9. AMY-1 interacts with this and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex. PMID: 12414807
    10. RIalpha and RIbeta homodimers as well as an RIalpha:RIbeta heterodimer and several of the mutants were able to bind to the R-binding domain of AKAP149/D-AKAP1 PMID: 12634056
    11. AKAP149-regulated PP1 activity at the NE during G1 is required to maintain nuclear integrity and cell survival. PMID: 12697839
    12. DAKAP1alpha overexpression induced regulatory (R) or catalytic (C) subunits of PKA to outer mitochondrial colocalization and showed similar regulation PMID: 17884635
    13. both the constitutive and cAMP-induced release of TNFR1 exosome-like vesicles occur via PKA-dependent pathways that are regulated by the anchoring of RIIbeta to BIG2 via AKAP domains B and C PMID: 18625701
    14. Results suggest that the interaction between reverse transcriptase and AKAP149 in infected cells may play an important role in HIV-1 reverse transcription. PMID: 18786546
    15. Protein phosphatase 1 binding occurs through a conserved RVXF motif found in the KH domain of AKAP149. PMID: 19074462

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Mitochondrion outer membrane. Mitochondrion.
  • 組織特異性:
    Isoform 1 is detected in thymus, prostate, testis, ovary, colon and small intestine. Isoform 2 is highly expressed in testis and detected at much lower levels in kidney, pancreas, liver, lung and brain.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 367

    OMIM: 602449

    KEGG: hsa:8165

    STRING: 9606.ENSP00000337736

    UniGene: Hs.463506



主站蜘蛛池模板: 99久久免费国产精精品| 熟妇女人妻丰满少妇中文字幕| 性生交大全免费看| 亚洲人成无码www久久久| 国产精品一区二区久久乐下载| 冲田杏梨av一区二区三区| 97人妻无码专区| 国内精品自在自线视频| 国产精品久久久久蜜芽| 夜夜添无码一区二区三区| 97精品久久久久中文字幕| 成人毛片无码免费播放网站| 日本特黄aaaaaa片在线观看| 久久精品道一区二区三区| 国产爆乳成av人在线播放| 中文字幕人妻中文av不卡专区| 成人性生交大片免费看96| 亚洲综合色婷婷七月丁香| 超薄丝袜足j好爽在线观看 | 国产在线不卡精品网站| 天天天天躁天天爱天天碰2018| 亚洲综合无码一区二区三区| 亚洲国产一区二区三区在观看| 亚洲 欧美精品suv| 无码人妻一区二区三区av| 香港三级精品三级在线专区| 无码av免费毛片一区二区| 亚洲精品综合一区二区三区在线| 青青草国产三级精品三级| 国产精品久久久久久久久鸭 | 国产99久9在线视频 | 传媒| 欧美丰满熟妇xxxx性ppx人| 8888四色奇米在线观看| 少妇人妻av毛片在线看| 亚洲和欧洲一码二码区别7777| 亚洲人成无码网www动漫| 国产精华av午夜在线| 免费人妻av无码专区| 亚洲国产精品无码久久一线| 久久精品国产99久久久小说| 久久无码高潮喷水|