在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

AKAP1 Antibody

  • 中文名稱:
    AKAP1兔多克隆抗體
  • 貨號:
    CSB-PA098862
  • 規(guī)格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from HUVEC cells and COLO cells, using AKAP1 antibody.
    • Immunohistochemistry analysis of paraffin-embedded human brain tissue using AKAP1 antibody.
    • Immunofluorescence analysis of COS7 cells, using AKAP1 antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) AKAP1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    AKAP1
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from internal of Human AKAP1.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC,IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
    IF 1:100-1:500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. Involved in mitochondrial-mediated antiviral innate immunity. Promotes translocation of NDUFS1 into mitochondria to regulate mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) activity.
  • 基因功能參考文獻:
    1. AKAP1 is a transcriptional target of Myc, and it supports mTOR pathway and the growth of cancer cells. PMID: 28569781
    2. Furthermore, we discuss the role of hypoxia in prompting cellular stress and damage, which has been demonstrated to mediate the proteosomal degradation of AKAP121, leading to an increase in reactive oxgyen species production, mitochondrial dysfunction, and ultimately cell death. [review] PMID: 26825124
    3. Functional characterization revealed an undescribed role for AMPK-dependent phosphorylation of AKAP1 in mitochondrial respiration. PMID: 26437602
    4. AKAP 149-PKA-PDE4A complex localization is related with YTX effect in K-562 cell line PMID: 24813785
    5. In the case of the beta2AR, this process is facilitated by the presence of A-Kinase Anchoring Proteins (AKAPs) that serve as scaffolding proteins for the L-type calcium channel and the beta2AR complex. PMID: 23557075
    6. AKAP1 anchors Star mRNA at the mitochondria, thus stabilizing the translational complex at this organelle, a situation that might affect STAR production and steroidogenesis. PMID: 23077346
    7. In tumoural lymphocytes, yessotoxin decreases AKAP149 cytosolic expression and increases cAMP levels which leads to cell death. PMID: 22807343
    8. Shp2 is a component of the AKAP-Lbc complex and is inhibited by protein kinase A under pathological hypertrophic conditions in the heart. PMID: 23045525
    9. AMY-1 interacts with this and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex. PMID: 12414807
    10. RIalpha and RIbeta homodimers as well as an RIalpha:RIbeta heterodimer and several of the mutants were able to bind to the R-binding domain of AKAP149/D-AKAP1 PMID: 12634056
    11. AKAP149-regulated PP1 activity at the NE during G1 is required to maintain nuclear integrity and cell survival. PMID: 12697839
    12. DAKAP1alpha overexpression induced regulatory (R) or catalytic (C) subunits of PKA to outer mitochondrial colocalization and showed similar regulation PMID: 17884635
    13. both the constitutive and cAMP-induced release of TNFR1 exosome-like vesicles occur via PKA-dependent pathways that are regulated by the anchoring of RIIbeta to BIG2 via AKAP domains B and C PMID: 18625701
    14. Results suggest that the interaction between reverse transcriptase and AKAP149 in infected cells may play an important role in HIV-1 reverse transcription. PMID: 18786546
    15. Protein phosphatase 1 binding occurs through a conserved RVXF motif found in the KH domain of AKAP149. PMID: 19074462

    顯示更多

    收起更多

  • 亞細胞定位:
    Mitochondrion outer membrane. Mitochondrion.
  • 組織特異性:
    Isoform 1 is detected in thymus, prostate, testis, ovary, colon and small intestine. Isoform 2 is highly expressed in testis and detected at much lower levels in kidney, pancreas, liver, lung and brain.
  • 數(shù)據庫鏈接:

    HGNC: 367

    OMIM: 602449

    KEGG: hsa:8165

    STRING: 9606.ENSP00000337736

    UniGene: Hs.463506



主站蜘蛛池模板: 最新永久无码av网址亚洲| 四虎永久地址www成人| 四川少妇大战4黑人| 久久精品国产免费观看| 精品人妻一区二区三区四区| 国产成人亚洲精品无码蜜芽| 日韩av爽爽爽久久久久久| 丝袜高潮流白浆潮喷在线播放| 在线观看成人无码中文av天堂不卡| 人妻中出受孕 中文字幕在线| 色婷婷一区二区三区四区成人网 | 欧美亚洲色综久久精品国产| 亚无码乱人伦一区二区| 国产女人喷潮视频免费| 亚洲国产av无码综合原创国产| 成人亚洲欧美激情在线电影| 东京热无码av一区二区| 人妻aⅴ中文字幕| 麻豆日产精品卡2卡3卡4卡5卡| 伊人久久大香线焦av综合影院| 大肉大捧一进一出好爽| 黑人粗长大战亚洲女| 青青草国产精品一区二区| 欧美日韩人妻精品一区二区在线| а天堂中文最新版在线| 天天做天天摸天天爽天天爱| 中文在线中文a| 4hu四虎永久在线影院| 亚洲高清毛片一区二区| 日本丰满少妇裸体自慰| 国产玉足脚交极品在线播放| 午夜成人性刺激免费视频| 国产精品无码天天爽视频| 中文字幕无码不卡一区二区三区| 人妻无码一区二区三区tv| 亚洲中文综合网五月俺也去| 无套内谢孕妇毛片免费看看| 无码高潮少妇毛多水多水免费 | 欧美性猛交xxxx乱大交| 国产精品夜间视频香蕉| 国产日韩欧美久久久精品图片|