在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

AKAP1 Antibody

  • 中文名稱:
    AKAP1兔多克隆抗體
  • 貨號:
    CSB-PA098862
  • 規(guī)格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from HUVEC cells and COLO cells, using AKAP1 antibody.
    • Immunohistochemistry analysis of paraffin-embedded human brain tissue using AKAP1 antibody.
    • Immunofluorescence analysis of COS7 cells, using AKAP1 antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) AKAP1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    AKAP1
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from internal of Human AKAP1.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC,IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
    IF 1:100-1:500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. Involved in mitochondrial-mediated antiviral innate immunity. Promotes translocation of NDUFS1 into mitochondria to regulate mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) activity.
  • 基因功能參考文獻:
    1. AKAP1 is a transcriptional target of Myc, and it supports mTOR pathway and the growth of cancer cells. PMID: 28569781
    2. Furthermore, we discuss the role of hypoxia in prompting cellular stress and damage, which has been demonstrated to mediate the proteosomal degradation of AKAP121, leading to an increase in reactive oxgyen species production, mitochondrial dysfunction, and ultimately cell death. [review] PMID: 26825124
    3. Functional characterization revealed an undescribed role for AMPK-dependent phosphorylation of AKAP1 in mitochondrial respiration. PMID: 26437602
    4. AKAP 149-PKA-PDE4A complex localization is related with YTX effect in K-562 cell line PMID: 24813785
    5. In the case of the beta2AR, this process is facilitated by the presence of A-Kinase Anchoring Proteins (AKAPs) that serve as scaffolding proteins for the L-type calcium channel and the beta2AR complex. PMID: 23557075
    6. AKAP1 anchors Star mRNA at the mitochondria, thus stabilizing the translational complex at this organelle, a situation that might affect STAR production and steroidogenesis. PMID: 23077346
    7. In tumoural lymphocytes, yessotoxin decreases AKAP149 cytosolic expression and increases cAMP levels which leads to cell death. PMID: 22807343
    8. Shp2 is a component of the AKAP-Lbc complex and is inhibited by protein kinase A under pathological hypertrophic conditions in the heart. PMID: 23045525
    9. AMY-1 interacts with this and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex. PMID: 12414807
    10. RIalpha and RIbeta homodimers as well as an RIalpha:RIbeta heterodimer and several of the mutants were able to bind to the R-binding domain of AKAP149/D-AKAP1 PMID: 12634056
    11. AKAP149-regulated PP1 activity at the NE during G1 is required to maintain nuclear integrity and cell survival. PMID: 12697839
    12. DAKAP1alpha overexpression induced regulatory (R) or catalytic (C) subunits of PKA to outer mitochondrial colocalization and showed similar regulation PMID: 17884635
    13. both the constitutive and cAMP-induced release of TNFR1 exosome-like vesicles occur via PKA-dependent pathways that are regulated by the anchoring of RIIbeta to BIG2 via AKAP domains B and C PMID: 18625701
    14. Results suggest that the interaction between reverse transcriptase and AKAP149 in infected cells may play an important role in HIV-1 reverse transcription. PMID: 18786546
    15. Protein phosphatase 1 binding occurs through a conserved RVXF motif found in the KH domain of AKAP149. PMID: 19074462

    顯示更多

    收起更多

  • 亞細胞定位:
    Mitochondrion outer membrane. Mitochondrion.
  • 組織特異性:
    Isoform 1 is detected in thymus, prostate, testis, ovary, colon and small intestine. Isoform 2 is highly expressed in testis and detected at much lower levels in kidney, pancreas, liver, lung and brain.
  • 數(shù)據庫鏈接:

    HGNC: 367

    OMIM: 602449

    KEGG: hsa:8165

    STRING: 9606.ENSP00000337736

    UniGene: Hs.463506



主站蜘蛛池模板: 久久天天躁狠狠躁夜夜avapp| 亚洲精品图片区小说区| 狠狠色丁香久久婷婷综合_中| 国产精品成人99久久久久| 国产又大又硬又粗| 女人裸体性做爰视频| 亚洲经典国产精华液单品榜| 熟妇激情内射com| 欧美浓毛大泬视频| 毛片免费全部无码播放| 国产av中文av无码av狼人| 中文字幕精品亚洲人成在线| 人妻无码人妻有码中文字幕| 无码人妻丰满熟妇啪啪网站| 日本久久综合久久综合| 婷婷成人小说综合专区| 国产麻豆剧传媒精品国产av| 丝袜人妻一区二区三区| 中文字幕精品视频在线看免费| 蜜桃av麻豆av果冻传媒| 久久久久女教师免费一区| 国产精品一区二区av蜜芽| 国内少妇高潮嗷嗷叫在线播放| 久久99国产综合精品| 两根大肉大捧一进一出好爽视频 | 成人影院yy111111在线| 欧美丰满熟妇多毛xxxxx| 色欲色香天天天综合网www| 欧美巨大xxxx做受高清| 综合久久—本道中文字幕| 亚洲综合色无码| 自拍偷在线精品自拍偷无码专区| av无码免费岛国动作片片段欣赏网| 大香网伊人久久综合网2018 | 亚洲国产三级在线观看| 欧美xxxx精品另类| 日本一区二区a√成人片| 亚洲综合成人av一区在线观看| 乱女伦露脸对白在线播放| 人人做人人妻人人精| 国产精品一区在线蜜臀|