在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

AHCY Antibody

  • 中文名稱:
    AHCY兔多克隆抗體
  • 貨號:
    CSB-PA001474HA01HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA001474HA01HU at dilution of 1:100
    • Immunofluorescence staining of HepG2 cells with CSB-PA001474HA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) AHCY Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    AHCY
  • 別名:
    Adenosylhomocysteinase antibody; AdoHcyase antibody; ahcY antibody; S adenosyl L homocysteine hydrolase antibody; S adenosylhomocysteine hydrolase antibody; S-adenosyl-L-homocysteine hydrolase antibody; SAHH antibody; SAHH_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Adenosylhomocysteinase protein (2-432AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,AHCY Antibody (CSB-PA001474HA01HU),的標記方式是Non-conjugated。對于AHCY Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA001474HB01HU AHCY Antibody, HRP conjugated ELISA
    FITC CSB-PA001474HC01HU AHCY Antibody, FITC conjugated
    Biotin CSB-PA001474HD01HU AHCY Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.
  • 基因功能參考文獻:
    1. Results uncover a H19/SAHH circuit involving gene-methylation alterations by carcinogen BaP. PMID: 29772428
    2. We investigated previously assumed interaction with AHCY-like-1 protein (AHCYL1), a paralog of AHCY. Indeed, significant interaction between both proteins exists. Additionally, silencing AHCYL1 leads to moderate inhibition of nuclear export of endogenous AHCY. PMID: 28647132
    3. We have validated the vectors and confirmed self-association of AHCY, AHCYL1, and galectin-3. In a high-throughput BiFC screen, we identified new AHCY interaction partners: galectin-3 and PUS7L. We also describe additional steps in protein interaction analysis, applied for AHCY-galectin-3 interaction PMID: 27455993
    4. In order to enable the development of small molecule AHCY inhibitors as targeted cancer therapeutics we developed an assay based on a RapidFire high-throughput mass spectrometry detection system, which allows the direct measurement of AHCY enzymatic activity. PMID: 28533090
    5. SAH hydrolase deficiency can remain asymptomatic in childhood, and the disorder can be associated with early onset hepatocellular carcinoma. PMID: 26527160
    6. H19 knockdown activates SAHH, leading to increased DNMT3B-mediated methylation of an lncRNA-encoding gene Nctc1 within the Igf2-H19-Nctc1 locus. PMID: 26687445
    7. S-adenosylhomocysteine hydrolase is regulated by lysine acetylation PMID: 25248746
    8. SAHH can promote apoptosis, inhibit migration and adhesion of ESCC cells suggesting that it may be involved in carcinogenesis of the esophagus. PMID: 24430301
    9. A fluorescence-based assay for the measurement of S-adenosylhomocysteine hydrolase activity in biological samples. PMID: 23079506
    10. The simulations of ligand-induced transition revealed that the signal of intrasubunit closure dynamics is transmitted to form intersubunit contacts, which in turn invoke a precise alignment of active site. PMID: 22023331
    11. Five active site residues (E156, N181, K186, D190, N191) of AdoHcy hydrolase have been individually mutated to alanine and each engineered enzyme characterized with respect to its redox partial reaction and elimination/addition partial reaction. PMID: 12069606
    12. a discussion of its hydrolytic activity (review) PMID: 12369977
    13. Maintenance of ionizable active-site residues in catalytically suitable protonation states in closed forms of placental AHCY may be assisted by a water chain, stabilized by Asp182, that can import and export protons from and to the environment. PMID: 12590576
    14. AdoHcy is involved in adenosine-induced apoptosis by altering gene expression. PMID: 17097637
    15. R38W and G123R amino-acid exchanges did not bring about major changes to the catalytic rates. However, circular dichroism analysis showed that both polymorphisms effect the thermal stability. PMID: 17164794
    16. SAHH, which is diffuse in the cytoplasm of nonmotile Dictyostelium amoebae and human neutrophils, concentrates with F-actin in pseudopods at the front of motile, chemotaxing cells PMID: 17172447
    17. In the case of Hs-SAHH, the slow-binding phase terminates in micromolar affinity, but over a period of hours, the dissociation rate constant decreases until the final equilibrium affinity is in the nanomolar range. PMID: 17447732
    18. We found clinically relevant levels of Hcy (0-500 microM) induced elevation of SAH, declination of SAM and SAM/SAH ratio and reduced expression of SAHH and MBD2, but increased activity of DNMT3a and DNMT3b affecting DNA methylation PMID: 17688412
    19. The mechanism of action of copper on this enzyme sugges a regulative role for copper on the intracellular activity. PMID: 17892301
    20. consider changes in charge and the sterical incompatibility in mutant p.A89V protein as main reason for enzyme malfunction with AdoHcyase deficiency as consequence PMID: 18211827
    21. SAHH from Homo sapiens (Hs-SAHH) and from the parasite Trypanosoma cruzi (Tc-SAHH) are very similar in structure and catalytic properties but differ in the kinetics and thermodynamics of association and dissociation of the cofactor NAD (+) PMID: 18393535
    22. Streptococcal pyrogenic exotoxin B (SPE B) potentially causes immunosuppression by cleaving human S-adenosylhomocysteine hydrolase (AdoHcyase). PMID: 18522500
    23. increased plasma concentration in patients with idiopathic thrombocytopenic purpura PMID: 18683034
    24. SAHH mRNA was lost in 50% of tumor tissues from 206 patients with different kinds of tumors in comparison with normal tissue counterparts. Moreover, SAHH protein was also affected in some colon cancers PMID: 18713839
    25. These data show that 2-5-fold enhanced AdoHcyase activity is well tolerated by the cell, while greatly enhanced AdoHcyase activity results in adenosine-induced apoptosis. PMID: 18769049
    26. S-adenosylhomocysteine hydrolase PMID: 19619139

    顯示更多

    收起更多

  • 相關疾病:
    Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD)
  • 亞細胞定位:
    Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • 蛋白家族:
    Adenosylhomocysteinase family
  • 數據庫鏈接:

    HGNC: 343

    OMIM: 180960

    KEGG: hsa:191

    STRING: 9606.ENSP00000217426

    UniGene: Hs.388004



主站蜘蛛池模板: 天堂网www在线资源网| 久久天天躁狠狠躁夜夜夜| 国产精品自在线拍亚洲另类| 无码精品国产va在线观看| 99精品电影一区二区免费看| 亚洲中文字幕无码av永久| 久久亚洲国产精品123区| 国产成人精品s8视频| 久久午夜羞羞影院免费观看| 50岁退休熟女露脸高潮| 办公丝袜av一区二区三区| 成人免费乱码大片a毛片| 亚洲精品中文字幕乱码| 天堂中文在线资源| 久久亚洲精品无码gv| 中文字幕无码av免费久久| 精品人妻中文无码av在线| 亚洲欧美精品suv| 国产午睡沙发被弄醒完整版| 人妻聚色窝窝人体www一区| 国内老熟妇对白hdxxxx| 精品亚洲一区二区三区在线播放| 18禁精品久久久国产精品久久久| 国产乱人伦中文无无码视频试看| 女人爽得直叫免费视频| 婷婷五月俺也去人妻| 又色又爽又黄又无遮挡的网站| 欧美激情视频一区二区三区免费 | 精品夜夜澡人妻无码av| 国语自产免费精品视频在| 中文字幕丝袜第1页| 少妇扒开粉嫩小泬视频| 丁香五月亚洲综合深深爱| 人妻少妇无码中文幕久久| 国产丰满老熟妇乱xxx1区| 好紧好爽好湿别拔出来视频男男| 2019亚洲午夜无码天堂| 伊人亚洲大杳蕉色无码| 亚洲一区二区观看播放| 国产午夜精华2020在线| 色综合伊人丁香五月桃花婷婷|