在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

AHCY Antibody, HRP conjugated

  • 中文名稱:
    AHCY兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA001474HB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) AHCY Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    AHCY
  • 別名:
    Adenosylhomocysteinase antibody; AdoHcyase antibody; ahcY antibody; S adenosyl L homocysteine hydrolase antibody; S adenosylhomocysteine hydrolase antibody; S-adenosyl-L-homocysteine hydrolase antibody; SAHH antibody; SAHH_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Adenosylhomocysteinase protein (2-432AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.
  • 基因功能參考文獻:
    1. Results uncover a H19/SAHH circuit involving gene-methylation alterations by carcinogen BaP. PMID: 29772428
    2. We investigated previously assumed interaction with AHCY-like-1 protein (AHCYL1), a paralog of AHCY. Indeed, significant interaction between both proteins exists. Additionally, silencing AHCYL1 leads to moderate inhibition of nuclear export of endogenous AHCY. PMID: 28647132
    3. We have validated the vectors and confirmed self-association of AHCY, AHCYL1, and galectin-3. In a high-throughput BiFC screen, we identified new AHCY interaction partners: galectin-3 and PUS7L. We also describe additional steps in protein interaction analysis, applied for AHCY-galectin-3 interaction PMID: 27455993
    4. In order to enable the development of small molecule AHCY inhibitors as targeted cancer therapeutics we developed an assay based on a RapidFire high-throughput mass spectrometry detection system, which allows the direct measurement of AHCY enzymatic activity. PMID: 28533090
    5. SAH hydrolase deficiency can remain asymptomatic in childhood, and the disorder can be associated with early onset hepatocellular carcinoma. PMID: 26527160
    6. H19 knockdown activates SAHH, leading to increased DNMT3B-mediated methylation of an lncRNA-encoding gene Nctc1 within the Igf2-H19-Nctc1 locus. PMID: 26687445
    7. S-adenosylhomocysteine hydrolase is regulated by lysine acetylation PMID: 25248746
    8. SAHH can promote apoptosis, inhibit migration and adhesion of ESCC cells suggesting that it may be involved in carcinogenesis of the esophagus. PMID: 24430301
    9. A fluorescence-based assay for the measurement of S-adenosylhomocysteine hydrolase activity in biological samples. PMID: 23079506
    10. The simulations of ligand-induced transition revealed that the signal of intrasubunit closure dynamics is transmitted to form intersubunit contacts, which in turn invoke a precise alignment of active site. PMID: 22023331
    11. Five active site residues (E156, N181, K186, D190, N191) of AdoHcy hydrolase have been individually mutated to alanine and each engineered enzyme characterized with respect to its redox partial reaction and elimination/addition partial reaction. PMID: 12069606
    12. a discussion of its hydrolytic activity (review) PMID: 12369977
    13. Maintenance of ionizable active-site residues in catalytically suitable protonation states in closed forms of placental AHCY may be assisted by a water chain, stabilized by Asp182, that can import and export protons from and to the environment. PMID: 12590576
    14. AdoHcy is involved in adenosine-induced apoptosis by altering gene expression. PMID: 17097637
    15. R38W and G123R amino-acid exchanges did not bring about major changes to the catalytic rates. However, circular dichroism analysis showed that both polymorphisms effect the thermal stability. PMID: 17164794
    16. SAHH, which is diffuse in the cytoplasm of nonmotile Dictyostelium amoebae and human neutrophils, concentrates with F-actin in pseudopods at the front of motile, chemotaxing cells PMID: 17172447
    17. In the case of Hs-SAHH, the slow-binding phase terminates in micromolar affinity, but over a period of hours, the dissociation rate constant decreases until the final equilibrium affinity is in the nanomolar range. PMID: 17447732
    18. We found clinically relevant levels of Hcy (0-500 microM) induced elevation of SAH, declination of SAM and SAM/SAH ratio and reduced expression of SAHH and MBD2, but increased activity of DNMT3a and DNMT3b affecting DNA methylation PMID: 17688412
    19. The mechanism of action of copper on this enzyme sugges a regulative role for copper on the intracellular activity. PMID: 17892301
    20. consider changes in charge and the sterical incompatibility in mutant p.A89V protein as main reason for enzyme malfunction with AdoHcyase deficiency as consequence PMID: 18211827
    21. SAHH from Homo sapiens (Hs-SAHH) and from the parasite Trypanosoma cruzi (Tc-SAHH) are very similar in structure and catalytic properties but differ in the kinetics and thermodynamics of association and dissociation of the cofactor NAD (+) PMID: 18393535
    22. Streptococcal pyrogenic exotoxin B (SPE B) potentially causes immunosuppression by cleaving human S-adenosylhomocysteine hydrolase (AdoHcyase). PMID: 18522500
    23. increased plasma concentration in patients with idiopathic thrombocytopenic purpura PMID: 18683034
    24. SAHH mRNA was lost in 50% of tumor tissues from 206 patients with different kinds of tumors in comparison with normal tissue counterparts. Moreover, SAHH protein was also affected in some colon cancers PMID: 18713839
    25. These data show that 2-5-fold enhanced AdoHcyase activity is well tolerated by the cell, while greatly enhanced AdoHcyase activity results in adenosine-induced apoptosis. PMID: 18769049
    26. S-adenosylhomocysteine hydrolase PMID: 19619139

    顯示更多

    收起更多

  • 相關疾病:
    Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD)
  • 亞細胞定位:
    Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • 蛋白家族:
    Adenosylhomocysteinase family
  • 數據庫鏈接:

    HGNC: 343

    OMIM: 180960

    KEGG: hsa:191

    STRING: 9606.ENSP00000217426

    UniGene: Hs.388004



主站蜘蛛池模板: 国产卡一卡二无线乱码| 国产熟妇乱xxxxx大屁股网| 一本加勒比波多野结衣| 熟睡人妻被讨厌的公侵犯| 日本三级韩国三级欧美三级| 99re6在线视频精品免费下载 | 成 人 网 站 免费 在线| 少妇的丰满人妻hd高清| 色老板精品视频在线观看| 性欧美老人牲交xxxxx视频| 2018年亚洲欧美在线v| 欧美变态另类xxxx| 翘臀后进少妇大白嫩屁股| 久久热最新网站获取| 久久久久久久久久久综合日本 | 图片小说视频一区二区| 免费国产a国产片高清| 亚洲综合小说专区图片| 四虎国产精品永久在线无码| 无码喷水一区二区浪潮av| 国产精品白浆无码流出| 日日碰狠狠躁久久躁96avv| 久久久久久伊人高潮影院| 久久精品中文字幕有码| 亚洲欧美成人一区二区在线电影 | 国产一区二区三区小说| 国产精品久久福利网站| 日本毛茸茸的丰满熟妇| 精品露脸国产偷人在视频| 亚洲女同一区二区| 免费无码国产v片在线观看 | 精品国产一二三产品区别在哪| 国产成人精品自在线拍| 久久精品国产亚洲7777| 中文字幕欧美日韩va免费视频 | 狠狠色噜噜狠狠狠888米奇视频 | 成人亚洲一区无码久久| 99精品国产一区二区三区a片| 亚洲а∨天堂久久精品2021| 国产精品无码av天天爽 | 亚洲人成人无码网www国产|