在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

AGRP Antibody, HRP conjugated

  • 中文名稱:
    AGRP兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA05699B0Rb
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) AGRP Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Agouti related neuropeptide antibody; Agouti Related Protein Homolog antibody; Agouti-related protein antibody; Agrp antibody; AGRP_HUMAN antibody; AGRT antibody; ART antibody; ASIP2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Agouti-related protein (83-132AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R. Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.
  • 基因功能參考文獻:
    1. AgRP is not associated with changes in hunger or satiety, and can change without corresponding changes in leptin. This suggests that AgRP may not be involved in the episodic control of appetite and the release of AgRP may involve signals other than leptin. PMID: 27476955
    2. data provide compelling evidence that AgRP is a heparan sulfate-binding protein and localizes critical regions in the AgRP structure required for this interaction. PMID: 28264929
    3. The aim of this survey is to evaluate the association of genetic variants of melanocortin-4-receptor (MC4R), pro-opiomelanocortin (POMC), apolipoprotein E (APOE) and agouti-related protein (AGRP) with obesity in the North Indian population. PMID: 26226973
    4. CSF AgRP was not different in lean vs. overweight/obese subjects; however, plasma AgRP was higher in lean subjects. PMID: 26152765
    5. human agouti-related protein has a role in enhancing expression and stability of human melanocortin-4 receptor PMID: 25446108
    6. Variations in genes AGRP, CPE, GHRL, GLP1R, HTR2A, NPY1R, NPY5R, SOCS3 and STAT3 showed modest associations with BMI in European Americans. PMID: 23900445
    7. Elevations in AgRP also favor the diagnosis of ectopic ACTH syndrome, suggesting AgRP should be further evaluated as a potential neuroendocrine tumor marker. PMID: 25013995
    8. AGRP SNP (rs1338993) was not associated with antipsychotic-induced weight gain in schizophrenia patients. PMID: 24564533
    9. Data suggest that prolonged steady-state exercise/physical activity at moderate intensity elicits substantial increases in blood lactate and cortisol concentrations without a significant change in AgRP; study was pilot project involving men. PMID: 22477065
    10. Despite peripheral hyperleptinemia, positive energy balance is achieved during pregnancy by a relative decrease in central leptin concentrations and resistance to leptin's effects on target neuropeptides that regulate energy balance. PMID: 23118421
    11. AgRP and NPY are correlated with body weight changes, rather than the presence of type 2 diabetes, whereas changes in alphaMSH immunoreactivity are related to the presence of type 2 diabetes, indicating separate hypothalamic mechanisms. PMID: 22492775
    12. Cognitive flexibility plays an important role in anorexia nervosa and may be modulated by abnormal levels of the appetite-regulating peptide AGRP. PMID: 21531082
    13. This review defines how peripheral signals (particularly leptin, insulin and glucose) converge on a molecular level in proopiomelanocortin (POMC)- and agouti-related protein (AgRP)-expressing arcuate nucleus neurons to control energy homeostasis. PMID: 19770186
    14. Only the patients with nonalcoholic fatty liver presented a positive correlation between the saturated fatty acids intake and the orexigenic neuropeptides NPY and agouti related protein, and carbohydrate with NPY PMID: 20164781
    15. AgRP may provide an important signal in the immune environment and the lymphocyte may be considered as an extra-hypothalamic source of plasma AgRP following exercise stress PMID: 20404050
    16. Agouti-related protein is neatively correlated with nonalcolic fatty liver disease in obese adolescents. PMID: 19942238
    17. A polymorphism, 199G>A, resulted in substitution of the amino acid at position 67 from alanine to threonine. PMID: 11602360
    18. NMR structural studies show that the loop in the first 16 residues of the C-terminal domain of AGRP confers distinct selectivity for melanocortin receptors MC3R and MC4R. PMID: 11747427
    19. the c.199G-->A polymorphism in hAGRP could play a role in the development of human obesity in an age-dependent fashion PMID: 12213871
    20. Ala67Thr polymorphism in the Agouti-related peptide gene is associated with inherited leanness in humans PMID: 15054840
    21. Two single nucleotide polymorphisms in the AGRP promotor showed opposite effects on promotor activity. PMID: 15121772
    22. Serum levels could serve as useful peripheral markers of changes in energy homeostasis. PMID: 15546902
    23. the C-terminus of AgRP can participate in the insulin secretion in pancreatic beta cells, through the modulation of calcium release PMID: 15978665
    24. Single-nucleotide polymorphisms found in anorexia nervosa. PMID: 16314751
    25. AgRP may have a novel inhibitory paracrine role in the human adrenal gland PMID: 16320160
    26. analysis of molecular basis of melanocortin-4 receptor for AGRP inverse agonism PMID: 16820227
    27. Plasma Agouti-related protein (AGRP)elevation may be related to energy homeostasis disturbance in anorexia nervosa, and in addition to leptin, peripheral AGRP levels could be used as a nutritional marker in AN patients. PMID: 16904835
    28. in addition to its inverse agonistic activities, Agrp exhibits agonistic properties on the endocytosis pathway of melanocortin-3 and -4 receptors PMID: 17041250
    29. a rare mutation, +79G>A, was identified in the AGRP minimal promoter; the +79G>A mutation could predispose to body weight gain PMID: 17180153
    30. two adjacent enhancers inside the first intron of the neighboring (1.4 kb downstream) ATPase gene (ATP6V0D1) modulate the human AgRP promoter with profound spatiotemporal variation PMID: 19285986
    31. This study presents an association of rare allele of AGRP polymorphism in heterozygous state with increased body mass index PMID: 19602223
    32. The high expressing C/C genotype of AGRP was significantly associated with high BMI and type 2 diabetes in Africans. PMID: 11554767

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Obesity (OBESITY)
  • 亞細胞定位:
    Secreted. Golgi apparatus lumen.
  • 組織特異性:
    Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.
  • 數據庫鏈接:

    HGNC: 330

    OMIM: 601665

    KEGG: hsa:181

    STRING: 9606.ENSP00000290953

    UniGene: Hs.104633



主站蜘蛛池模板: 色婷婷欧美在线播放内射| 伊人狼人大焦香久久网| 国产卡一卡二无线乱码| 无码高潮爽到爆的喷水视频| 熟女丰满老熟女熟妇| 色www永久免费视频首页| 成人无码午夜在线观看| 国产成人综合在线视频| 久久无码av三级| 国产成人乱色伦区| 亚洲日本乱码中文在线电影| 国产男女猛烈无遮挡免费视频| 天天噜噜噜在线视频| 一卡二卡3卡4卡视频免费播放| 亚洲伦无码中文字幕另类| 亚洲天天做日日做天天谢日日欢 | 久久精品女人天堂av免费观看| 18禁白丝喷水视频www视频| 樱花草在线社区www中国中文| 成人a毛片视频免费看| 亚洲国产精品va在线看黑人| 男阳茎进女阳道视频大全| 天堂网www天堂在线资源| 在线看午夜福利片国产| 欧美日韩一区二区综合| 国产a√精品区二区三区四区| 日本成本人三级在线观看| 久久久国产精品黄毛片| 欧美午夜特黄aaaaaa片| 国产成人精品福利一区二区三区| 宅男色影视亚洲人在线| 麻豆av一区二区三区| yy6080久久伦理一区二区| av片日韩一区二区三区在线观看| 狠狠躁天天躁中文字幕无码| 亚洲精品白浆高清久久久久久| 久久久av男人的天堂| 国产精品人妻久久久久| 18禁裸体女免费观看| 欧洲熟妇色xxxxx视频| 中国美女牲交视频|