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  4. Human Agouti Related Protein,AGRP ELISA Kit

Human Agouti Related Protein,AGRP ELISA Kit

  • 中文名稱：
    人Agouti相關(guān)蛋白,AGRP酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E09299h
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人Agouti相關(guān)蛋白,AGRP酶聯(lián)免疫試劑盒（CSB-E09299h）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織培養(yǎng)上清液、尿液樣本中的AGRP含量。AGRP（Agouti Related Protein，刺鼠相關(guān)蛋白）是一種內(nèi)源性蛋白質(zhì)，與食欲和體重調(diào)節(jié)有關(guān)。研究顯示，AGRP神經(jīng)元在肥胖形成中起重要作用，其鈣穩(wěn)態(tài)調(diào)控對能量平衡至關(guān)重要。近期研究挑戰(zhàn)了AGRP神經(jīng)元在攝食和體重維持中的必要性，揭示了其可能并非不可或缺。試劑盒檢測范圍為31.25 pg/mL-2000 pg/mL，靈敏度為0.002 pg/mL。該產(chǎn)品適用于神經(jīng)內(nèi)分泌研究、代謝疾病機制探索、食欲調(diào)節(jié)相關(guān)藥物篩選等科研場景，特別針對能量代謝動物模型樣本分析、體外細(xì)胞模型分泌水平檢測等實驗需求設(shè)計，為研究AGRP在能量穩(wěn)態(tài)中的作用提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Agouti related neuropeptide ELISA Kit; Agouti Related Protein Homolog ELISA Kit; Agouti-related protein ELISA Kit; Agrp ELISA Kit; AGRP_HUMAN ELISA Kit; AGRT ELISA Kit; ART ELISA Kit; ASIP2 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, cell culture supernates, urine
  • 檢測范圍：
    31.25 pg/mL-2000 pg/mL
  • 靈敏度：
    0.002 pg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Cardiovascular
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：

    Intra-assay Precision (Precision within an assay): CV%<8%

     

    Three samples of known concentration were tested twenty times on one plate to assess.

     

    Inter-assay Precision (Precision between assays): CV%<10%

     

    Three samples of known concentration were tested in twenty assays to assess.

      

  • 線性度：

     To assess the linearity of the assay, samples were spiked with high concentrations of human AGRP in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.

  • 標(biāo)準(zhǔn)曲線：

     These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

     

  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 最新研究進(jìn)展：
        Agouti相關(guān)蛋白（Agouti-related protein，AGRP）是一種由下丘腦神經(jīng)元分泌的神經(jīng)肽，其在食欲和能量平衡調(diào)節(jié)中發(fā)揮重要作用。最新的研究進(jìn)展如下：
        AGRP在肥胖和糖尿病中的作用：AGRP已被證明是食欲和體重增加的主要因素之一。最新的研究表明，AGRP與肥胖和糖尿病密切相關(guān)。研究人員發(fā)現(xiàn)，AGRP與胰島素抵抗和胰島素分泌異常有關(guān)，因此成為研究和治療糖尿病的潛在靶點。
        AGRP與神經(jīng)系統(tǒng)疾病的關(guān)系：AGRP也與一些神經(jīng)系統(tǒng)疾病有關(guān)，如帕金森病、亞急性硬化性腦炎等。最新的研究表明，AGRP通過對神經(jīng)元和膠質(zhì)細(xì)胞的作用，可能參與調(diào)節(jié)神經(jīng)炎癥反應(yīng)和神經(jīng)退行性疾病的進(jìn)程。
        AGRP與生殖和性腺疾病的關(guān)系：AGRP在性腺功能和生殖過程中也發(fā)揮一定的作用。最新的研究表明，AGRP可能參與調(diào)節(jié)青春期和生殖周期的調(diào)節(jié)，與一些性腺疾病如多囊卵巢綜合癥等有關(guān)。
        AGRP與睡眠障礙的關(guān)系：AGRP也可能與睡眠障礙有關(guān)。最新的研究表明，AGRP能夠通過調(diào)節(jié)腦內(nèi)的睡眠調(diào)節(jié)中樞，影響睡眠質(zhì)量和睡眠時長。
  • 功能：
    Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R. Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.
  • 基因功能參考文獻(xiàn)：
    1. AgRP is not associated with changes in hunger or satiety, and can change without corresponding changes in leptin. This suggests that AgRP may not be involved in the episodic control of appetite and the release of AgRP may involve signals other than leptin. PMID: 27476955
    2. data provide compelling evidence that AgRP is a heparan sulfate-binding protein and localizes critical regions in the AgRP structure required for this interaction. PMID: 28264929
    3. The aim of this survey is to evaluate the association of genetic variants of melanocortin-4-receptor (MC4R), pro-opiomelanocortin (POMC), apolipoprotein E (APOE) and agouti-related protein (AGRP) with obesity in the North Indian population. PMID: 26226973
    4. CSF AgRP was not different in lean vs. overweight/obese subjects; however, plasma AgRP was higher in lean subjects. PMID: 26152765
    5. human agouti-related protein has a role in enhancing expression and stability of human melanocortin-4 receptor PMID: 25446108
    6. Variations in genes AGRP, CPE, GHRL, GLP1R, HTR2A, NPY1R, NPY5R, SOCS3 and STAT3 showed modest associations with BMI in European Americans. PMID: 23900445
    7. Elevations in AgRP also favor the diagnosis of ectopic ACTH syndrome, suggesting AgRP should be further evaluated as a potential neuroendocrine tumor marker. PMID: 25013995
    8. AGRP SNP (rs1338993) was not associated with antipsychotic-induced weight gain in schizophrenia patients. PMID: 24564533
    9. Data suggest that prolonged steady-state exercise/physical activity at moderate intensity elicits substantial increases in blood lactate and cortisol concentrations without a significant change in AgRP; study was pilot project involving men. PMID: 22477065
    10. Despite peripheral hyperleptinemia, positive energy balance is achieved during pregnancy by a relative decrease in central leptin concentrations and resistance to leptin's effects on target neuropeptides that regulate energy balance. PMID: 23118421
    11. AgRP and NPY are correlated with body weight changes, rather than the presence of type 2 diabetes, whereas changes in alphaMSH immunoreactivity are related to the presence of type 2 diabetes, indicating separate hypothalamic mechanisms. PMID: 22492775
    12. Cognitive flexibility plays an important role in anorexia nervosa and may be modulated by abnormal levels of the appetite-regulating peptide AGRP. PMID: 21531082
    13. This review defines how peripheral signals (particularly leptin, insulin and glucose) converge on a molecular level in proopiomelanocortin (POMC)- and agouti-related protein (AgRP)-expressing arcuate nucleus neurons to control energy homeostasis. PMID: 19770186
    14. Only the patients with nonalcoholic fatty liver presented a positive correlation between the saturated fatty acids intake and the orexigenic neuropeptides NPY and agouti related protein, and carbohydrate with NPY PMID: 20164781
    15. AgRP may provide an important signal in the immune environment and the lymphocyte may be considered as an extra-hypothalamic source of plasma AgRP following exercise stress PMID: 20404050
    16. Agouti-related protein is neatively correlated with nonalcolic fatty liver disease in obese adolescents. PMID: 19942238
    17. A polymorphism, 199G>A, resulted in substitution of the amino acid at position 67 from alanine to threonine. PMID: 11602360
    18. NMR structural studies show that the loop in the first 16 residues of the C-terminal domain of AGRP confers distinct selectivity for melanocortin receptors MC3R and MC4R. PMID: 11747427
    19. the c.199G-->A polymorphism in hAGRP could play a role in the development of human obesity in an age-dependent fashion PMID: 12213871
    20. Ala67Thr polymorphism in the Agouti-related peptide gene is associated with inherited leanness in humans PMID: 15054840
    21. Two single nucleotide polymorphisms in the AGRP promotor showed opposite effects on promotor activity. PMID: 15121772
    22. Serum levels could serve as useful peripheral markers of changes in energy homeostasis. PMID: 15546902
    23. the C-terminus of AgRP can participate in the insulin secretion in pancreatic beta cells, through the modulation of calcium release PMID: 15978665
    24. Single-nucleotide polymorphisms found in anorexia nervosa. PMID: 16314751
    25. AgRP may have a novel inhibitory paracrine role in the human adrenal gland PMID: 16320160
    26. analysis of molecular basis of melanocortin-4 receptor for AGRP inverse agonism PMID: 16820227
    27. Plasma Agouti-related protein (AGRP)elevation may be related to energy homeostasis disturbance in anorexia nervosa, and in addition to leptin, peripheral AGRP levels could be used as a nutritional marker in AN patients. PMID: 16904835
    28. in addition to its inverse agonistic activities, Agrp exhibits agonistic properties on the endocytosis pathway of melanocortin-3 and -4 receptors PMID: 17041250
    29. a rare mutation, +79G>A, was identified in the AGRP minimal promoter; the +79G>A mutation could predispose to body weight gain PMID: 17180153
    30. two adjacent enhancers inside the first intron of the neighboring (1.4 kb downstream) ATPase gene (ATP6V0D1) modulate the human AgRP promoter with profound spatiotemporal variation PMID: 19285986
    31. This study presents an association of rare allele of AGRP polymorphism in heterozygous state with increased body mass index PMID: 19602223
    32. The high expressing C/C genotype of AGRP was significantly associated with high BMI and type 2 diabetes in Africans. PMID: 11554767

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  • 相關(guān)疾病：
    Obesity (OBESITY)
  • 亞細(xì)胞定位：
    Secreted. Golgi apparatus lumen.
  • 組織特異性：
    Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 330

    OMIM: 601665

    KEGG: hsa:181

    STRING: 9606.ENSP00000290953

    UniGene: Hs.104633



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