在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ADRBK2 Antibody

  • 中文名稱:
    ADRBK2兔多克隆抗體
  • 貨號:
    CSB-PA648744
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA648744(ADRBK2 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA648744(ADRBK2 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    ADRBK2 antibody; Adrenergic; beta; receptor kinase 2 antibody; ARBK2_HUMAN antibody; BARK2 antibody; Beta adrenergic receptor kinase 2 antibody; Beta ARK 2 antibody; Beta-adrenergic receptor kinase 2 antibody; Beta-ARK-2 antibody; EC 2.7.11.15 antibody; G protein coupled receptor kinase 3 antibody; G-protein-coupled receptor kinase 3 antibody; GRK3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Fusion protein of Human ADRBK2
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.
  • 基因功能參考文獻:
    1. Study found that GRK3 was significantly overexpressed in 162 pairs of colon cancer tissues than in the matched noncancerous mucosa. These data show that aberrant expression of GRK3 plays an important role in promoting colon cancer progression through enhanced proliferation and reduced apoptosis. PMID: 29445249
    2. hat expression of GRK3 was down-regulated in pancreatic ductal adenocarcinoma and was an independent prognostic factor PMID: 29254792
    3. GRK3 is a new critical activator of neuroendocrine phenotypes and mediator of CREB activation in promoting neuroendocrine differentiation of prostate cancer cells. PMID: 27191986
    4. effects of GRK3 modulation appear to be specific to chemokine-mediated migration behaviors without influencing tumor cell proliferation or survival PMID: 27049755
    5. data are consistent with the possibility that oncogenes can induce cellular stiffness via an HDAC6-induced reorganization of the vimentin intermediate filament network PMID: 24434559
    6. In oral squamous cell carcinomas, malignant cells and surrounding tissue overexpress the ADRBK2 gene. PMID: 21916780
    7. A reduced cortical concentration of GRK3 in schizophrenia (resembling that in aging) may result in altered G protein-dependent signaling, thus contributing to prefrontal deficits in schizophrenia. PMID: 21784156
    8. GRK3 is a negative regulator of cell growth whose expression is preferentially reduced in glioblastoma of the classical subtype as a consequence of activity in primary gliomagenic pathways. PMID: 22086906
    9. mRNA levels for GRK3 were inversely correlated with systolic and diastolic blood pressure (day, night and 24 h), which suggests a protective role for GRK3 in the regulation of human blood pressure PMID: 20216086
    10. we found no evidence of altered levels of acetylated histone H3 at the affected allele compared to the common allele PMID: 19766236
    11. dysregulation in GRK3 expression alters signaling desensitization, and thereby predisposes to the development of bipolar disorder PMID: 12808434
    12. the CRH-R1alpha carboxyl tail is important for regulation of receptor activity by G protein-coupled receptor kinase PMID: 15498832
    13. ATP stimulation leads to GRK3 phosphorylation of P2X(7) receptor. PMID: 15728711
    14. No support for a major role for GRK3 gene promoter variants in cocaine addiction. PMID: 17621168
    15. Dysregulation in GRK3 expression alters signaling desensitization and thereby predisposes to the development of bipolar disease. PMID: 18075471
    16. role for GRK3 in regulating CXCR4 attenuation and have provided a mechanistic link between the GRK3 pathway and the CXCR4-related WHIM(WT) disorder. PMID: 18274673
    17. The G-384A variant may alter binding of Sp1/Sp4 transcription factors resulting in an increase in gene transcription and an increase in vulnerability to bipolar disorder. PMID: 18359007

    顯示更多

    收起更多

  • 蛋白家族:
    Protein kinase superfamily, AGC Ser/Thr protein kinase family, GPRK subfamily
  • 數據庫鏈接:

    HGNC: 290

    OMIM: 109636

    KEGG: hsa:157

    STRING: 9606.ENSP00000317578

    UniGene: Hs.657494



主站蜘蛛池模板: 真实国产乱子伦精品一区二区三区| 欧美丰满熟妇xxxxx| 久久午夜夜伦鲁鲁片免费无码影视| 玩弄丰满奶水的女邻居| 久久久久久无码av成人影院| 影音先锋女人av鲁色资源网久久| 久久视频在线视频| 国产成人免费无庶挡视频| 怡红院成永久免费人视频新的| 欧亚乱熟女一区二区在线| 香蕉午夜福利院| 久久永久免费专区人妻精品| 亚洲人成未满十八禁网站| 国产一区二区三区久久精品| www亚洲精品久久久| 亚洲一线产区二线产区分布| 人人妻人人澡av天堂香蕉| 特级毛片爽www免费版| 交换交换乱杂烩系列yy| 人妻性奴波多野结衣无码| 东京热久久综合久久88| 少妇熟女视频一区二区三区| 激情久久亚洲小说| 亚洲日本va中文字幕亚洲| 抽插丰满内射高潮视频| 日本一区二区三区免费更新不卡 | 无码国产69精品久久久久同性 | 在线a毛片免费视频观看| 久久久久久久97| 国精产品一区一区三区有限在线| 国内精品久久久久影院免费| 国产av一区二区精品久久凹凸 | 色妺妺视频网| 2018av天堂在线视频精品观看| 任你躁久久精品6| 久久99精品国产99久久6男男| 好爽别插了无码视频| 麻豆精产一二三产区 | 天天躁夜夜躁狠狠是什么心态 | 久久人妻无码中文字幕| 亚洲欧美人高清精品a∨|