在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GRK3 Antibody, Biotin conjugated

  • 中文名稱:
    GRK3兔多克隆抗體, Biotin偶聯(lián)
  • 貨號:
    CSB-PA001395LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) GRK3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    ADRBK2 antibody; Adrenergic; beta; receptor kinase 2 antibody; ARBK2_HUMAN antibody; BARK2 antibody; Beta adrenergic receptor kinase 2 antibody; Beta ARK 2 antibody; Beta-adrenergic receptor kinase 2 antibody; Beta-ARK-2 antibody; EC 2.7.11.15 antibody; G protein coupled receptor kinase 3 antibody; G-protein-coupled receptor kinase 3 antibody; GRK3 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Beta-adrenergic receptor kinase 2 protein (343-480AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.
  • 基因功能參考文獻(xiàn):
    1. Study found that GRK3 was significantly overexpressed in 162 pairs of colon cancer tissues than in the matched noncancerous mucosa. These data show that aberrant expression of GRK3 plays an important role in promoting colon cancer progression through enhanced proliferation and reduced apoptosis. PMID: 29445249
    2. hat expression of GRK3 was down-regulated in pancreatic ductal adenocarcinoma and was an independent prognostic factor PMID: 29254792
    3. GRK3 is a new critical activator of neuroendocrine phenotypes and mediator of CREB activation in promoting neuroendocrine differentiation of prostate cancer cells. PMID: 27191986
    4. effects of GRK3 modulation appear to be specific to chemokine-mediated migration behaviors without influencing tumor cell proliferation or survival PMID: 27049755
    5. data are consistent with the possibility that oncogenes can induce cellular stiffness via an HDAC6-induced reorganization of the vimentin intermediate filament network PMID: 24434559
    6. In oral squamous cell carcinomas, malignant cells and surrounding tissue overexpress the ADRBK2 gene. PMID: 21916780
    7. A reduced cortical concentration of GRK3 in schizophrenia (resembling that in aging) may result in altered G protein-dependent signaling, thus contributing to prefrontal deficits in schizophrenia. PMID: 21784156
    8. GRK3 is a negative regulator of cell growth whose expression is preferentially reduced in glioblastoma of the classical subtype as a consequence of activity in primary gliomagenic pathways. PMID: 22086906
    9. mRNA levels for GRK3 were inversely correlated with systolic and diastolic blood pressure (day, night and 24 h), which suggests a protective role for GRK3 in the regulation of human blood pressure PMID: 20216086
    10. we found no evidence of altered levels of acetylated histone H3 at the affected allele compared to the common allele PMID: 19766236
    11. dysregulation in GRK3 expression alters signaling desensitization, and thereby predisposes to the development of bipolar disorder PMID: 12808434
    12. the CRH-R1alpha carboxyl tail is important for regulation of receptor activity by G protein-coupled receptor kinase PMID: 15498832
    13. ATP stimulation leads to GRK3 phosphorylation of P2X(7) receptor. PMID: 15728711
    14. No support for a major role for GRK3 gene promoter variants in cocaine addiction. PMID: 17621168
    15. Dysregulation in GRK3 expression alters signaling desensitization and thereby predisposes to the development of bipolar disease. PMID: 18075471
    16. role for GRK3 in regulating CXCR4 attenuation and have provided a mechanistic link between the GRK3 pathway and the CXCR4-related WHIM(WT) disorder. PMID: 18274673
    17. The G-384A variant may alter binding of Sp1/Sp4 transcription factors resulting in an increase in gene transcription and an increase in vulnerability to bipolar disorder. PMID: 18359007

    顯示更多

    收起更多

  • 蛋白家族:
    Protein kinase superfamily, AGC Ser/Thr protein kinase family, GPRK subfamily
  • 數(shù)據(jù)庫鏈接:

    HGNC: 290

    OMIM: 109636

    KEGG: hsa:157

    STRING: 9606.ENSP00000317578

    UniGene: Hs.657494



主站蜘蛛池模板: 上司的丰满人妻中文字幕| 鲁鲁鲁爽爽爽在线视频观看| 乱色精品无码一区二区国产盗| 尤物av无码色av无码| 久久99精品久久久久久齐齐| 欧美两根一起进3p做受视频| 国产精品成人亚洲777| 久久爱www人成狠狠爱综合网| 99热这里只有精品国产免费免费| 亚洲人成在线观看网站无码| 成人区人妻精品一区二区不卡网站| 少妇被爽到高潮动态图| 亚洲男人的天堂网站| 2020年最新国产精品正在播放| 午夜嘿嘿嘿在线观看| 99国产精品欧美一区二区三区 | 日韩欧美成人免费观看| 国产精品激情欧美可乐视频 | 欧美日本韩国亚洲| 香蕉视频在线观看亚洲| 处破痛哭a√18成年片免费| 又粗又紧又湿又爽的视频| 亚洲精品一区二区精华液| 伊人久久大香线蕉亚洲五月天| 国产精品igao视频| 丰满少妇被粗大的猛烈进出视频| 亚洲国产剧情中文视频在线| 成人无码a∨电影免费| 亚洲va在线∨a天堂va欧美va | 国产又爽又猛又粗的视频a片| 欧美孕妇乳喷奶水在线观看| 伊人久久大香线蕉aⅴ色| 日韩精品久久久免费观看| 精品无码黑人又粗又大又长| 尤物视频在线观看| 黄页网站在线观看免费视频| 免费人成网站在线视频| 欧美性猛交xxxx乱大交| 亚洲精品字幕在线观看| 亚洲人成无码区在线观看| 做性久久久久久|