在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ADRBK2 Antibody

  • 中文名稱:
    ADRBK2兔多克隆抗體
  • 貨號:
    CSB-PA001395GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    ADRBK2 antibody; Adrenergic; beta; receptor kinase 2 antibody; ARBK2_HUMAN antibody; BARK2 antibody; Beta adrenergic receptor kinase 2 antibody; Beta ARK 2 antibody; Beta-adrenergic receptor kinase 2 antibody; Beta-ARK-2 antibody; EC 2.7.11.15 antibody; G protein coupled receptor kinase 3 antibody; G-protein-coupled receptor kinase 3 antibody; GRK3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human ADRBK2
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.
  • 基因功能參考文獻:
    1. Study found that GRK3 was significantly overexpressed in 162 pairs of colon cancer tissues than in the matched noncancerous mucosa. These data show that aberrant expression of GRK3 plays an important role in promoting colon cancer progression through enhanced proliferation and reduced apoptosis. PMID: 29445249
    2. hat expression of GRK3 was down-regulated in pancreatic ductal adenocarcinoma and was an independent prognostic factor PMID: 29254792
    3. GRK3 is a new critical activator of neuroendocrine phenotypes and mediator of CREB activation in promoting neuroendocrine differentiation of prostate cancer cells. PMID: 27191986
    4. effects of GRK3 modulation appear to be specific to chemokine-mediated migration behaviors without influencing tumor cell proliferation or survival PMID: 27049755
    5. data are consistent with the possibility that oncogenes can induce cellular stiffness via an HDAC6-induced reorganization of the vimentin intermediate filament network PMID: 24434559
    6. In oral squamous cell carcinomas, malignant cells and surrounding tissue overexpress the ADRBK2 gene. PMID: 21916780
    7. A reduced cortical concentration of GRK3 in schizophrenia (resembling that in aging) may result in altered G protein-dependent signaling, thus contributing to prefrontal deficits in schizophrenia. PMID: 21784156
    8. GRK3 is a negative regulator of cell growth whose expression is preferentially reduced in glioblastoma of the classical subtype as a consequence of activity in primary gliomagenic pathways. PMID: 22086906
    9. mRNA levels for GRK3 were inversely correlated with systolic and diastolic blood pressure (day, night and 24 h), which suggests a protective role for GRK3 in the regulation of human blood pressure PMID: 20216086
    10. we found no evidence of altered levels of acetylated histone H3 at the affected allele compared to the common allele PMID: 19766236
    11. dysregulation in GRK3 expression alters signaling desensitization, and thereby predisposes to the development of bipolar disorder PMID: 12808434
    12. the CRH-R1alpha carboxyl tail is important for regulation of receptor activity by G protein-coupled receptor kinase PMID: 15498832
    13. ATP stimulation leads to GRK3 phosphorylation of P2X(7) receptor. PMID: 15728711
    14. No support for a major role for GRK3 gene promoter variants in cocaine addiction. PMID: 17621168
    15. Dysregulation in GRK3 expression alters signaling desensitization and thereby predisposes to the development of bipolar disease. PMID: 18075471
    16. role for GRK3 in regulating CXCR4 attenuation and have provided a mechanistic link between the GRK3 pathway and the CXCR4-related WHIM(WT) disorder. PMID: 18274673
    17. The G-384A variant may alter binding of Sp1/Sp4 transcription factors resulting in an increase in gene transcription and an increase in vulnerability to bipolar disorder. PMID: 18359007

    顯示更多

    收起更多

  • 蛋白家族:
    Protein kinase superfamily, AGC Ser/Thr protein kinase family, GPRK subfamily
  • 數據庫鏈接:

    HGNC: 290

    OMIM: 109636

    KEGG: hsa:157

    STRING: 9606.ENSP00000317578

    UniGene: Hs.657494



主站蜘蛛池模板: 亚洲性人人天天夜夜摸| 中文字幕 欧美精品 第1页| 国产精品久久人妻互换| 国产精品久久久久久不卡盗摄| 狠狠色狠狠色综合日日五| 中文字幕人乱码中文| 中文字幕亚韩| 日韩av无码精品人妻系列| 久久久国产精品亚洲一区 | 亚洲精品久久久久久成人| 欧美处交wwwvideos另类| 国产av国片精品一区二区| 免费少妇荡乳情欲视频| 一区二区在线 | 欧洲| …日韩人妻无码精品一专区| 国产精品制服| 婷婷五月俺也去人妻| 国产av偷闻女邻居内裤被发现| 国产激情高中生呻吟视频| 无码国产69精品久久久久网站| 在线精品国产成人综合| 久久久精品人妻久久影视| 四川老熟女下面又黑又肥| 国产成人最新三级在线视频| 久久久久国色av∨免费看| 亚洲色成人影院在线观看| 久久精品国产一区二区三区不卡| 在线观看特色大片免费网站| 日韩精品区一区二区三vr| 国产98色在线 | 国| 久久亚洲精品无码gv| 国产又粗又硬又大爽黄老大爷| www插插插无码免费视频网站| 老鸭窝视频在线观看| 久久国产主播福利在线| 亚洲 日韩 欧美 有码 在线| 国内丰满熟女出轨videos| 日韩精品亚洲人成在线观看| 免费午夜爽爽爽www视频十八禁| 毛片完整版的免费观看| 亚洲色欲在线播放一区|