在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ADRBK2 Antibody

  • 中文名稱:
    ADRBK2兔多克隆抗體
  • 貨號:
    CSB-PA001395GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    ADRBK2 antibody; Adrenergic; beta; receptor kinase 2 antibody; ARBK2_HUMAN antibody; BARK2 antibody; Beta adrenergic receptor kinase 2 antibody; Beta ARK 2 antibody; Beta-adrenergic receptor kinase 2 antibody; Beta-ARK-2 antibody; EC 2.7.11.15 antibody; G protein coupled receptor kinase 3 antibody; G-protein-coupled receptor kinase 3 antibody; GRK3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human ADRBK2
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.
  • 基因功能參考文獻:
    1. Study found that GRK3 was significantly overexpressed in 162 pairs of colon cancer tissues than in the matched noncancerous mucosa. These data show that aberrant expression of GRK3 plays an important role in promoting colon cancer progression through enhanced proliferation and reduced apoptosis. PMID: 29445249
    2. hat expression of GRK3 was down-regulated in pancreatic ductal adenocarcinoma and was an independent prognostic factor PMID: 29254792
    3. GRK3 is a new critical activator of neuroendocrine phenotypes and mediator of CREB activation in promoting neuroendocrine differentiation of prostate cancer cells. PMID: 27191986
    4. effects of GRK3 modulation appear to be specific to chemokine-mediated migration behaviors without influencing tumor cell proliferation or survival PMID: 27049755
    5. data are consistent with the possibility that oncogenes can induce cellular stiffness via an HDAC6-induced reorganization of the vimentin intermediate filament network PMID: 24434559
    6. In oral squamous cell carcinomas, malignant cells and surrounding tissue overexpress the ADRBK2 gene. PMID: 21916780
    7. A reduced cortical concentration of GRK3 in schizophrenia (resembling that in aging) may result in altered G protein-dependent signaling, thus contributing to prefrontal deficits in schizophrenia. PMID: 21784156
    8. GRK3 is a negative regulator of cell growth whose expression is preferentially reduced in glioblastoma of the classical subtype as a consequence of activity in primary gliomagenic pathways. PMID: 22086906
    9. mRNA levels for GRK3 were inversely correlated with systolic and diastolic blood pressure (day, night and 24 h), which suggests a protective role for GRK3 in the regulation of human blood pressure PMID: 20216086
    10. we found no evidence of altered levels of acetylated histone H3 at the affected allele compared to the common allele PMID: 19766236
    11. dysregulation in GRK3 expression alters signaling desensitization, and thereby predisposes to the development of bipolar disorder PMID: 12808434
    12. the CRH-R1alpha carboxyl tail is important for regulation of receptor activity by G protein-coupled receptor kinase PMID: 15498832
    13. ATP stimulation leads to GRK3 phosphorylation of P2X(7) receptor. PMID: 15728711
    14. No support for a major role for GRK3 gene promoter variants in cocaine addiction. PMID: 17621168
    15. Dysregulation in GRK3 expression alters signaling desensitization and thereby predisposes to the development of bipolar disease. PMID: 18075471
    16. role for GRK3 in regulating CXCR4 attenuation and have provided a mechanistic link between the GRK3 pathway and the CXCR4-related WHIM(WT) disorder. PMID: 18274673
    17. The G-384A variant may alter binding of Sp1/Sp4 transcription factors resulting in an increase in gene transcription and an increase in vulnerability to bipolar disorder. PMID: 18359007

    顯示更多

    收起更多

  • 蛋白家族:
    Protein kinase superfamily, AGC Ser/Thr protein kinase family, GPRK subfamily
  • 數據庫鏈接:

    HGNC: 290

    OMIM: 109636

    KEGG: hsa:157

    STRING: 9606.ENSP00000317578

    UniGene: Hs.657494



主站蜘蛛池模板: 狠狠综合久久av一区二区| 人妻中文乱码在线网站| 国产特级毛片aaaaaa高清| 国产蜜臀av在线一区尤物| 久久精品成人无码观看不卡| 影音先锋无码a∨男人资源站| 亚洲欧美不卡视频在线播放| 蜜臀av在线播放一区二区三区| 久久午夜夜伦鲁鲁片无码免费| 亚洲日韩欧美国产另类综合| a狠狠久久蜜臀婷色中文网| 亚洲国产精品无码久久| 中国极品少妇xxxxx| www国产内插视频| 无码任你躁久久久久久老妇蜜桃 | 亚洲欧美日本韩国| 狠狠色噜噜狠狠狠狠色综合久av| 草草网站影院白丝内射| 午夜大片免费男女爽爽影院| 成人精品视频一区二区三区| 国产免费人成视频在线播放播| 日本丰满人妻xxxxxhd| 国产日韩一区二区三免费高清| 亚洲高清无在码在线电影不卡| 亚洲精品卡一卡三卡四卡乱码| 国产交换配乱婬视频| 国产麻豆天美果冻无码视频| 欧美牲交a欧美牲交aⅴ另类| 免费国产精品视频在线| 午夜国产亚洲精品一区| 伴郎粗大的内捧猛烈进出视频观看| 国产欧美va欧美va香蕉在| 亚洲精品久久久久久久久久久捆绑 | 成人区人妻精品一区二区三区| 又污又爽又黄的网站| 天堂√最新版中文在线天堂| 国产精品扒开腿做爽爽爽a片唱戏| 亚洲欧美色一区二区三区| 国产真实偷乱视频| 中文字幕av无码一二三区电影| 少妇性饥渴无码a区免费|