在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ADAMTS2 Antibody

  • 中文名稱:
    ADAMTS2兔多克隆抗體
  • 貨號:
    CSB-PA801690
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA801690(ADAMTS2 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA801690(ADAMTS2 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: A431 and 293T cell, Primary antibody: CSB-PA801690(ADAMTS2 Antibody) at dilution 1/200 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    ADAMTS2
  • 別名:
    A disintegrin and metalloproteinase with thrombospondin motifs 2 antibody; A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 2 antibody; ADAM metallopeptidase with thrombospondin type 1 motif 2 antibody; ADAM TS 2 antibody; ADAM TS2 antibody; ADAM-TS 2 antibody; ADAM-TS2 antibody; ADAMTS 3 antibody; ADAMTS-2 antibody; ADAMTS2 antibody; ATS2_HUMAN antibody; EC 3.4.24.14 antibody; EDS VIIB antibody; EDS VIIC antibody; hPCPNI antibody; NPI antibody; PC I NP antibody; PC I-NP antibody; PCINP antibody; PCPNI antibody; pNPI antibody; Procollagen I N proteinase antibody; Procollagen I N-proteinase antibody; Procollagen I/II amino propeptide processing enzyme antibody; Procollagen I/II amino propeptide-processing enzyme antibody; Procollagen N endopeptidase antibody; Procollagen N-endopeptidase antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthetic peptide of Human ADAMTS2
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form with reduced collagen-binding activity.
  • 基因功能參考文獻:
    1. We identified three novel homozygous loss-of-function mutations (c.2927_2928delCT, p.(Pro976Argfs*42); c.669_670dupG, p.(Pro224Argfs*24); and c.2751-2A>T) and one compound heterozygous mutation (c.2T>C, p.? and c.884_887delTGAA, p.(Met295Thrfs26*)) in ADAMTS2 in five patients from four unrelated families PMID: 26765342
    2. Data indicate that ADAMTS2 and 3 cleave the amino-propeptide of fibrillar collagens and regulate blood vessels homeostasis and lymphangiogenesis. Also, ADAMTS2 deficiency leads to the dermatosparactic type of Ehlers-Danlos syndrome. [review] PMID: 25863161
    3. IL-1a is a strong positive regulator of ADAMTS-2 and ADAMTS-3 expression. PMID: 26232334
    4. ADAMTS2 was significantly overexpressed in Fibrous dysplasia (FD) tissues, but rarely expressed in normal bone tissues, suggesting that ADAMTS2 could be a potential biomarker for FD PMID: 25674217
    5. Pathway inhibition studies revealed that ADAMTS-2 upregulation by IL-6 was mediated by JNK pathway. PMID: 24752352
    6. Data show that ADAMTS-2 is able to reduce proliferation of endothelial cells, and to induce their retraction and detachment from the substrate resulting in apoptosis. PMID: 20574651
    7. Determination of the processing, activity and cleavage specificity of the bovine ADAMTS2 protein. PMID: 16046392
    8. when conditioned media of TSP2-transfectants were added to cultures of bovine pulmonary microvascular endothelial cells (BPMEC), the BPMEC proliferation was significantly inhibited; suggesting that human TSP2 is a potential inhibitor of angiogenesis PMID: 11788898
    9. Although exons 3-5 or 14-16 encode protein domains that have not been recognized as crucial for ADAMTS-2 activity, the aminoprocollagen processing was strongly impaired, providing evidence for the requirement of these domains for proper enzyme function PMID: 15373769

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Ehlers-Danlos syndrome 7C (EDS7C)
  • 亞細胞定位:
    Secreted, extracellular space, extracellular matrix.
  • 組織特異性:
    Expressed at high level in skin, bone, tendon and aorta and at low levels in thymus and brain.
  • 數據庫鏈接:

    HGNC: 218

    OMIM: 225410

    KEGG: hsa:9509

    STRING: 9606.ENSP00000251582

    UniGene: Hs.23871



主站蜘蛛池模板: 国模无码人体一区二区| 欧美成人片在线观看| 日本丰满少妇裸体自慰| 免费网站观看www在线观看| 国产suv精品一区二区33| 国产亚洲精品久久久久久大师| 久久久久爽爽爽爽一区老女人| 五月丁香啪啪激情综合色九色| 亚洲乱码中文字幕小综合| 欧美 日韩 国产 成人 在线观看| 樱花草在线社区www| 亚洲欧洲日韩国内高清| 97久久国产成人免费网站| 牲交欧美兽交欧美| 一 级做人爱全视频在线看 | 精品噜噜噜噜久久久久久久久| 亚洲欧洲免费三级网站| 国产小受呻吟gv视频在线观看| 人妻饥渴偷公乱中文字幕| 国产超碰人人爽人人做| 暖暖 免费 高清 日本 在线 | 亚洲在线国产日韩欧美| 中无码人妻丰满熟妇啪啪| 久久国国产免费999| 国产色婷婷亚洲99精品小说| 日韩精品人妻系列无码专区| 无码av一区二区大桥久未| 人妻熟女久久久久久久| 美丽的熟妇中文字幕| 亚洲一区二区女搞男| 成人午夜无码精品免费看| 国内精品久久人妻互换| 久久亚洲一区二区三区四区| 久久久亚洲欧洲日产国码αv| 56pao国产成视频永久| 成人片黄网站色大片免费毛片| 中文字幕丰满乱孑伦无码专区 | 久久人搡人人玩人妻精品| 亚洲一区精品二人人爽久久| 久久精品国产自在天天线| 蜜柚av久久久久久久|