在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 試劑盒
  3. 酶聯免疫試劑盒
  4. Human A disintegrin and metalloproteinase with thrombospondin motifs 2(ADAMTS2) ELISA kit

Human A disintegrin and metalloproteinase with thrombospondin motifs 2(ADAMTS2) ELISA kit

  • 中文名稱：
    人金屬肽酶含血小板反應蛋白2(ADAMTS2)酶聯免疫試劑盒
  • 貨號：
    CSB-EL001308HU
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    人金屬肽酶含血小板反應蛋白2(ADAMTS2)酶聯免疫試劑盒（CSB-EL001308HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的ADAMTS2含量。ADAMTS2是一種細胞外金屬蛋白酶，參與細胞外基質破壞、血管平滑肌細胞分型與凋亡、炎癥細胞浸潤、氧化應激等復雜機制。其在心臟肥厚、肝纖維化等疾病中發揮重要作用，通過調節PI3K/Akt信號通路影響心肌細胞肥大反應。試劑盒檢測范圍為3.12 ng/mL-200 ng/mL，支持科研人員探究 ADAMTS2 在皮膚彈性維持、器官纖維化病理機制或腫瘤微環境調控中的作用，為疾病模型構建、藥物靶點篩選及生物標志物研究提供可靠工具本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    A disintegrin and metalloproteinase with thrombospondin motifs 2 ELISA Kit; A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 2 ELISA Kit; ADAM metallopeptidase with thrombospondin type 1 motif 2 ELISA Kit; ADAM TS 2 ELISA Kit; ADAM TS2 ELISA Kit; ADAM-TS 2 ELISA Kit; ADAM-TS2 ELISA Kit; ADAMTS 3 ELISA Kit; ADAMTS-2 ELISA Kit; ADAMTS2 ELISA Kit; ATS2_HUMAN ELISA Kit; EC 3.4.24.14 ELISA Kit; EDS VIIB ELISA Kit; EDS VIIC ELISA Kit; hPCPNI ELISA Kit; NPI ELISA Kit; PC I NP ELISA Kit; PC I-NP ELISA Kit; PCINP ELISA Kit; PCPNI ELISA Kit; pNPI ELISA Kit; Procollagen I N proteinase ELISA Kit; Procollagen I N-proteinase ELISA Kit; Procollagen I/II amino propeptide processing enzyme ELISA Kit; Procollagen I/II amino propeptide-processing enzyme ELISA Kit; Procollagen N endopeptidase ELISA Kit; Procollagen N-endopeptidase ELISA Kit
  • 縮寫：
    ADAMTS2
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    3.12 ng/mL-200 ng/mL
  • 靈敏度：
    0.78 ng/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Cell Biology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human ADAMTS2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 90
    Range % 85-95
    1:2 Average % 92
    Range % 88-96
    1:4 Average % 87
    Range % 82-91
    1:8 Average % 95
    Range % 90-100
  • 回收率：
    The recovery of human ADAMTS2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 102 98-109
    EDTA plasma (n=4) 97 92-101
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average Corrected
    200 2.129 2.238 2.184 2.023
    100 1.737 1.682 1.710 1.549
    50 1.112 1.174 1.143 0.982
    25 0.719 0.741 0.730 0.569
    12.5 0.480 0.459 0.470 0.309
    6.25 0.360 0.350 0.355 0.194
    3.12 0.239 0.247 0.243 0.082
    0 0.159 0.163 0.161 　
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form with reduced collagen-binding activity.
  • 基因功能參考文獻：
    1. We identified three novel homozygous loss-of-function mutations (c.2927_2928delCT, p.(Pro976Argfs*42); c.669_670dupG, p.(Pro224Argfs*24); and c.2751-2A>T) and one compound heterozygous mutation (c.2T>C, p.? and c.884_887delTGAA, p.(Met295Thrfs26*)) in ADAMTS2 in five patients from four unrelated families PMID: 26765342
    2. Data indicate that ADAMTS2 and 3 cleave the amino-propeptide of fibrillar collagens and regulate blood vessels homeostasis and lymphangiogenesis. Also, ADAMTS2 deficiency leads to the dermatosparactic type of Ehlers-Danlos syndrome. [review] PMID: 25863161
    3. IL-1a is a strong positive regulator of ADAMTS-2 and ADAMTS-3 expression. PMID: 26232334
    4. ADAMTS2 was significantly overexpressed in Fibrous dysplasia (FD) tissues, but rarely expressed in normal bone tissues, suggesting that ADAMTS2 could be a potential biomarker for FD PMID: 25674217
    5. Pathway inhibition studies revealed that ADAMTS-2 upregulation by IL-6 was mediated by JNK pathway. PMID: 24752352
    6. Data show that ADAMTS-2 is able to reduce proliferation of endothelial cells, and to induce their retraction and detachment from the substrate resulting in apoptosis. PMID: 20574651
    7. Determination of the processing, activity and cleavage specificity of the bovine ADAMTS2 protein. PMID: 16046392
    8. when conditioned media of TSP2-transfectants were added to cultures of bovine pulmonary microvascular endothelial cells (BPMEC), the BPMEC proliferation was significantly inhibited; suggesting that human TSP2 is a potential inhibitor of angiogenesis PMID: 11788898
    9. Although exons 3-5 or 14-16 encode protein domains that have not been recognized as crucial for ADAMTS-2 activity, the aminoprocollagen processing was strongly impaired, providing evidence for the requirement of these domains for proper enzyme function PMID: 15373769

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Ehlers-Danlos syndrome 7C (EDS7C)
  • 亞細胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 組織特異性：
    Expressed at high level in skin, bone, tendon and aorta and at low levels in thymus and brain.
  • 數據庫鏈接：

    HGNC: 218

    OMIM: 225410

    KEGG: hsa:9509

    STRING: 9606.ENSP00000251582

    UniGene: Hs.23871



主站蜘蛛池模板： 国产成人综合久久精品推最新| 美女网站免费观看视频| 亚洲中文字幕久久无码精品| 草草久久97超级碰碰碰| 亚洲色爱免费观看视频| 亚洲成av人片在线观看无码 | 日韩亚洲欧美中文高清在线| 天堂在线观看www| 性欧美疯狂xxxxbbbb| 中文字幕亚洲男人的天堂网络 | 日韩无套内射高潮| 亚洲 丝袜 另类 校园 欧美 | 麻豆国产精品va在线观看| 韩国 欧美 日产 国产精品| 精品久久久久香蕉网 | av东京热无码专区| 爆乳熟妇一区二区三区| 亚洲旡码a∨一区二区三区| 伊人久久大香线蕉av五月天| 国产熟妇久久777777| 国产人与禽zoz0性伦| 久久精品国产99国产精2020丨| 亚洲精品无码不卡在线播放he| 福利姬国产精品一区在线| 国产精品igao视频| 精产国品一区二区三产区| 又色又爽又黄的美女裸体网站| 国产色情又大又粗又黄的电影| 丰满少妇熟乱xxxxx视频| 狠狠色综合网久久久久久| 亚洲午夜成人精品无码app| 无码午夜福利免费区久久| 久久无码人妻精品一区二区三区| 天天爱天天做天天做天天吃中文| 欧美 日本 国产 在线a∨观看| 国产精品久久久久无码av色戒| 精品久久久久久无码专区 | 成人网站国产在线视频内射视频| 国产精品久久久久9999爆乳| 无码高潮又爽又黄a片软件| 久久精品国产只有精品96|