在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ACVR1C Antibody

  • 中文名稱:
    ACVR1C兔多克隆抗體
  • 貨號:
    CSB-PA001259GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Activin A receptor; type IC antibody; Activin receptor like kinase 7 antibody; Activin receptor type 1C precursor antibody; Activin receptor type IC antibody; Activin receptor type-1C antibody; Activin receptor-like kinase 7 antibody; ACTR IC antibody; ACTR-IC antibody; ACTRIC antibody; ACV1C_HUMAN antibody; Acvr1c antibody; ACVRLK7 antibody; ALK 7 antibody; ALK-7 antibody; ALK7 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human ACVR1C
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
  • 基因功能參考文獻:
    1. reduced expression in sensitive skin; plays crucial roles in the pathogenesis of sensitive skin PMID: 26836979
    2. Loss of ALK7 expression are associated with invasion, metastasis of the pancreatic ductal adenocarcinoma. PMID: 26406402
    3. Alk7 is expressed in male germ cells and Sertoli cells. PMID: 26289399
    4. ACVR 1C is a tumor suppressor, and lowered ACVR 1C expression is an important marker for the metastasis, invasion, and prognosis of gallbladder cancer. PMID: 23793810
    5. Our findings suggested that the ALK7 gene polymorphism rs13010956 was significantly associated with metabolic syndrome risk in females and may be involved in cardiovascular remodeling in metabolic syndrome patients. PMID: 23765385
    6. reduction or lack of ALK7 expression may account for the loss of its ligand sensitivity of breast cancer cells, thereby leading to breast tumor progression. PMID: 22086737
    7. These findings suggest that the Nodal/ALK7 pathway plays important roles in human placentation and that its abnormal signaling may contribute to the development of preeclampsia. PMID: 21356369
    8. cDNA cloning, expression studies and chromosome mapping PMID: 12063393
    9. ALK7 and its isoforms are expressed in human placentae of different stages of pregnancy and that their expression is developmentally regulated PMID: 12606401
    10. ALK7 induces apoptosis through activation of the traditional TGF-beta pathway components PMID: 15107418
    11. the Nodal-ALK7 pathway inhibits cell proliferation by inducing G(1) cell cycle arrest PMID: 15150278
    12. AB and activin B and is responsible for activin-mediated secretion of insulin from pancreatic beta cell line, MIN6. PMID: 15196700
    13. ALK7-induced apoptosis is at least in part through two Smad-dependent pathways, Bax/Bcl-2 and Xiap. PMID: 16603637
    14. GDF3 regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the ALK7 receptor PMID: 18480259
    15. The antiproliferative effect of Nodal/ALK7 on ovarian cancer cells is in part mediated by cyclin G2. PMID: 18784254
    16. One of the direct target genes in the ALK7 signaling pathway is the insulin gene in pancreatic beta-cells, and that PDX-1 is directly involved in this pathway through interaction with Smad2 and Smad3. PMID: 18951876
    17. Microarray analysis showed that adipose tissue expressed activin type I and II receptors and that the expression of activin receptor-like kinase 7 was adipose tissue specific. PMID: 19275893

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily
  • 組織特異性:
    Present in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy.
  • 數據庫鏈接:

    HGNC: 18123

    OMIM: 608981

    KEGG: hsa:130399

    STRING: 9606.ENSP00000243349

    UniGene: Hs.562901



主站蜘蛛池模板: 欧美成人免费一区二区| 亚洲无线码中文字幕在线| 日韩在线成年视频人网站观看| 2022国产成人精品视频人| 国产成人精品一区二三区在线观看 | 国产一区二区无码蜜芽精品| 欧美日韩精品成人网站二区| 久久久久99精品成人片| 欧美人与动牲交a欧美精品| 亚洲-av-无限看| 噜噜色综合天天综合网mp3| 国产乱女乱子视频在线播放| 成人国产亚洲精品a区天堂| 久久久久久久极品内射| 国产亚洲福利在线视频| 国产午夜av秒播在线观看| 我把护士日出水了视频90分钟 | 国产 精品 自在 线免费| 亚洲精品国产自在久久| 久久精品亚洲中文无东京热 | 日日拍夜夜嗷嗷叫国产| 夜夜躁狠狠躁日日躁202| 无码a∨高潮抽搐流白浆| 粉嫩av国产一区二区三区| 欧美黑人又大又粗xxxxx| 国产精品有码无码av在线播放| 久久久一本精品久久精品六六| 国产又色又爽又刺激在线播放| 日本老熟妇毛茸茸| 成在人线av无码免费高潮喷水| 中国少妇偷人hd| 欧美浓毛大泬视频| 欧美变态另类牲交zozo| 色噜噜狠狠色综合网| 欧美成人精品一区二区三区色欲| 黑人巨大精品欧美一区二区| 国产成人a人亚洲精品无码 | 99久久国产综合精品麻豆| 国内精品视这里只有精品| 亚洲欧洲日产国产 最新| 欧美变态口味重另类在线视频|