在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ACVR1C Antibody

  • 中文名稱:
    ACVR1C兔多克隆抗體
  • 貨號:
    CSB-PA001259GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Activin A receptor; type IC antibody; Activin receptor like kinase 7 antibody; Activin receptor type 1C precursor antibody; Activin receptor type IC antibody; Activin receptor type-1C antibody; Activin receptor-like kinase 7 antibody; ACTR IC antibody; ACTR-IC antibody; ACTRIC antibody; ACV1C_HUMAN antibody; Acvr1c antibody; ACVRLK7 antibody; ALK 7 antibody; ALK-7 antibody; ALK7 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human ACVR1C
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
  • 基因功能參考文獻:
    1. reduced expression in sensitive skin; plays crucial roles in the pathogenesis of sensitive skin PMID: 26836979
    2. Loss of ALK7 expression are associated with invasion, metastasis of the pancreatic ductal adenocarcinoma. PMID: 26406402
    3. Alk7 is expressed in male germ cells and Sertoli cells. PMID: 26289399
    4. ACVR 1C is a tumor suppressor, and lowered ACVR 1C expression is an important marker for the metastasis, invasion, and prognosis of gallbladder cancer. PMID: 23793810
    5. Our findings suggested that the ALK7 gene polymorphism rs13010956 was significantly associated with metabolic syndrome risk in females and may be involved in cardiovascular remodeling in metabolic syndrome patients. PMID: 23765385
    6. reduction or lack of ALK7 expression may account for the loss of its ligand sensitivity of breast cancer cells, thereby leading to breast tumor progression. PMID: 22086737
    7. These findings suggest that the Nodal/ALK7 pathway plays important roles in human placentation and that its abnormal signaling may contribute to the development of preeclampsia. PMID: 21356369
    8. cDNA cloning, expression studies and chromosome mapping PMID: 12063393
    9. ALK7 and its isoforms are expressed in human placentae of different stages of pregnancy and that their expression is developmentally regulated PMID: 12606401
    10. ALK7 induces apoptosis through activation of the traditional TGF-beta pathway components PMID: 15107418
    11. the Nodal-ALK7 pathway inhibits cell proliferation by inducing G(1) cell cycle arrest PMID: 15150278
    12. AB and activin B and is responsible for activin-mediated secretion of insulin from pancreatic beta cell line, MIN6. PMID: 15196700
    13. ALK7-induced apoptosis is at least in part through two Smad-dependent pathways, Bax/Bcl-2 and Xiap. PMID: 16603637
    14. GDF3 regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the ALK7 receptor PMID: 18480259
    15. The antiproliferative effect of Nodal/ALK7 on ovarian cancer cells is in part mediated by cyclin G2. PMID: 18784254
    16. One of the direct target genes in the ALK7 signaling pathway is the insulin gene in pancreatic beta-cells, and that PDX-1 is directly involved in this pathway through interaction with Smad2 and Smad3. PMID: 18951876
    17. Microarray analysis showed that adipose tissue expressed activin type I and II receptors and that the expression of activin receptor-like kinase 7 was adipose tissue specific. PMID: 19275893

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily
  • 組織特異性:
    Present in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy.
  • 數據庫鏈接:

    HGNC: 18123

    OMIM: 608981

    KEGG: hsa:130399

    STRING: 9606.ENSP00000243349

    UniGene: Hs.562901



主站蜘蛛池模板: 不卡无码av一区二区三区| 国产做a爰片久久毛片a片| 中文国产成人精品久久app| 亚洲日韩av无码| 国产白袜脚足j棉袜在线观看| 精品国内自产拍在线观看视频| 久久/这里只精品热在线获取| 亚洲国产人成自精在线尤物| 亚洲国产一区二区精品无码| 亚洲人成小说网站色| 亚洲大尺度无码专区尤物 | 一个人看的www视频免费观看| 亚洲经典千人经典日产| 欧亚精品一区三区免费| 69成人免费视频无码专区| 性欧美videofree高清精品| 污污污污污污污网站污| 国产又色又爽又刺激在线播放| 久久国产欧美日韩精品| 吃奶呻吟打开双腿做受在线视频| 国产在线观看免费观看不卡| 97精品国产一区二区三区四区| 日本成本人片免费网站| 久久精品亚洲日本波多野结衣| 久久久亚洲色| 97色伦综合在线欧美视频| 忘忧草社区在线资源www| 国产亚洲精品久久久久久老妇小说| 蜜桃视频一区二区三区在线观看| 50岁退休熟女露脸高潮| 忘忧草日本在线www| 影音先锋无码a∨男人资源站| 久久99九九精品久久久久蜜桃| 中文字幕亚韩| 学生妹亚洲一区二区| 与子敌伦刺激对白播放的优点| 国产成人8x人在线视频软件| 天天鲁在视频在线观看| 国产精品偷窥熟女精品视频| 亚洲国产成人片在线观看无码| 热99re久久精品天堂|