在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ACVR1C Antibody

  • 中文名稱:
    ACVR1C兔多克隆抗體
  • 貨號:
    CSB-PA007118
  • 規格:
    ¥1090
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Activin A receptor; type IC antibody; Activin receptor like kinase 7 antibody; Activin receptor type 1C precursor antibody; Activin receptor type IC antibody; Activin receptor type-1C antibody; Activin receptor-like kinase 7 antibody; ACTR IC antibody; ACTR-IC antibody; ACTRIC antibody; ACV1C_HUMAN antibody; Acvr1c antibody; ACVRLK7 antibody; ALK 7 antibody; ALK-7 antibody; ALK7 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human ACTR-IC.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    IHC, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
  • 基因功能參考文獻:
    1. reduced expression in sensitive skin; plays crucial roles in the pathogenesis of sensitive skin PMID: 26836979
    2. Loss of ALK7 expression are associated with invasion, metastasis of the pancreatic ductal adenocarcinoma. PMID: 26406402
    3. Alk7 is expressed in male germ cells and Sertoli cells. PMID: 26289399
    4. ACVR 1C is a tumor suppressor, and lowered ACVR 1C expression is an important marker for the metastasis, invasion, and prognosis of gallbladder cancer. PMID: 23793810
    5. Our findings suggested that the ALK7 gene polymorphism rs13010956 was significantly associated with metabolic syndrome risk in females and may be involved in cardiovascular remodeling in metabolic syndrome patients. PMID: 23765385
    6. reduction or lack of ALK7 expression may account for the loss of its ligand sensitivity of breast cancer cells, thereby leading to breast tumor progression. PMID: 22086737
    7. These findings suggest that the Nodal/ALK7 pathway plays important roles in human placentation and that its abnormal signaling may contribute to the development of preeclampsia. PMID: 21356369
    8. cDNA cloning, expression studies and chromosome mapping PMID: 12063393
    9. ALK7 and its isoforms are expressed in human placentae of different stages of pregnancy and that their expression is developmentally regulated PMID: 12606401
    10. ALK7 induces apoptosis through activation of the traditional TGF-beta pathway components PMID: 15107418
    11. the Nodal-ALK7 pathway inhibits cell proliferation by inducing G(1) cell cycle arrest PMID: 15150278
    12. AB and activin B and is responsible for activin-mediated secretion of insulin from pancreatic beta cell line, MIN6. PMID: 15196700
    13. ALK7-induced apoptosis is at least in part through two Smad-dependent pathways, Bax/Bcl-2 and Xiap. PMID: 16603637
    14. GDF3 regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the ALK7 receptor PMID: 18480259
    15. The antiproliferative effect of Nodal/ALK7 on ovarian cancer cells is in part mediated by cyclin G2. PMID: 18784254
    16. One of the direct target genes in the ALK7 signaling pathway is the insulin gene in pancreatic beta-cells, and that PDX-1 is directly involved in this pathway through interaction with Smad2 and Smad3. PMID: 18951876
    17. Microarray analysis showed that adipose tissue expressed activin type I and II receptors and that the expression of activin receptor-like kinase 7 was adipose tissue specific. PMID: 19275893

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily
  • 組織特異性:
    Present in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy.
  • 數據庫鏈接:

    HGNC: 18123

    OMIM: 608981

    KEGG: hsa:130399

    STRING: 9606.ENSP00000243349

    UniGene: Hs.562901



主站蜘蛛池模板: 99久久无码一区人妻| 国产精品久久久爽爽爽麻豆色哟哟| 色天使久久综合网天天| 四虎影视永久地址www成人| 动漫精品专区一区二区三区不卡| 欧美人与善在线com| 久久麻豆成人精品av| 免费看成人啪啪| 亚洲 自拍 另类小说综合图区| 欧美香蕉爽爽人人爽| 婷婷五月综合色中文字幕| 国精品无码一区二区三区左线| 国产亚洲精品久久久久久牛牛 | 欧美日本亚洲韩国一区| 中文字幕在线影视| 亚洲国产精品久久精品| 亚洲欧美精品suv| 亚洲乱码中文论理电影| 日本在线视频www色| 忍不住的亲子中文字幕| 日韩精品乱码av一区二区 | 720lu国产刺激无码| 中文字幕无线码中文字幕免费| 粗了大了 整进去好爽视频| 国产素人在线观看人成视频| 岛国无码av不卡一区二区| 国产freexxxx性播放麻豆| 亚洲精品电影院| 精品一区二区三区国产在线观看| 亚洲午夜久久久精品影院| 色一情一区二区三区四区| 亚洲欧美日韩二三区在线| 久久精品av国产一区二区| 人妻无码一区二区三区四区| 变态 另类 欧美 大码 日韩| 亚洲欧洲日产国产 最新| 婷婷综合久久中文字幕| 久久久久噜噜噜亚洲熟女综合| 亚洲国产成人无码av在线影院| 2019国产品在线视频| 亚洲人av高清无码|