在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ACTG2 Antibody

  • 中文名稱:
    ACTG2兔多克隆抗體
  • 貨號:
    CSB-PA000812
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of COLO205 cells using Actin α3 Polyclonal Antibody
    • Western Blot analysis of mouse-heart mouse-lung cells using Actin α3 Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    ACT antibody; ACTA3 antibody; ACTE antibody; ACTG2 antibody; ACTH_HUMAN antibody; Actin antibody; Actin gamma 2 smooth muscle enteric antibody; Actin gamma enteric smooth muscle antibody; Actin like protein antibody; ACTL3 antibody; ACTSG antibody; Alpha actin 3 antibody; Alpha-actin-3 antibody; Gamma 2 actin antibody; Gamma-2-actin antibody; gamma-enteric smooth muscle antibody; Smooth muscle gamma actin antibody; Smooth muscle gamma-actin antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the N-terminal region of Human Actin α3.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
  • 基因功能參考文獻:
    1. fetus with intestinal pseudo-obstruction heterozygous for p.R63G pathogenic variant (NM_001615.3 c.187C>G; rs864309491) in exon 3 PMID: 29072330
    2. Whole exome and Sanger sequencing revealed a pathogenic variant in the ACTG2 gene in 4 out of 28 probands with chronic intestinal pseudo-obstruction and megacystis. Moreover, a mutational hotspot in the ACTG2 gene was recognized. Genetic heterogeneity is evident. PMID: 28422808
    3. R257 variant in the ACTG2 appear to be more frequent in populations of Asian ancestry; mutation of this locus could cause alterations of the intestinal and bladder smooth muscle filaments. PMID: 27007401
    4. ACTG2 boosts the metastatic potential of hepatocellular carcinoma in a Notch1-dependent manner. PMID: 28385530
    5. Missense variants in ACTG2 were identified in the patients with either megacystis-microcolon-intestinal hypoperistalsis syndrome or intestinal pseudo-obstruction. PMID: 26813947
    6. A heterozygous missense variant in ACTG2 was identified that impaired actin polymerization in sporadic Megacystis microcolon intestinal hypoperistalsis syndrome. PMID: 26647307
    7. ACTG2 is expressed in a fraction of small intestinal neuroendocrine tumors, can inhibit cell growth in vitro, and is positively regulated by miR-145. PMID: 27107594
    8. Mutations within ACTG2 are associated with fetal megacystis in microcolon intestinal hypoperistalsis syndrome. PMID: 25998219
    9. Phenotypic spectrum of ACTG2 missense variants involved severe pathology in multiple smooth muscle-dependent organs including the biliary tract and the uterus in the family with visceral myopathy. PMID: 25782675
    10. gammaSMA expression in hepatocellular carcinoma is strongly correlated with the EMT process, HCC aggressiveness and the identification of cancer stem cells PMID: 26110787
    11. ACTG2 encodes g2 enteric actin and is the first gene to be clearly associated with Megacystis-microcolon-intestinal hypoperistalsis syndrome, suggesting an important role for contractile proteins in enteric smooth muscle disease. PMID: 24676022
    12. Two novel mutations in the ACTG2 gene, p.R178L and p.R178C, have been identified in two unrelated children with congenital distended bladder, microcolon, and intestinal hypoperistalsis (MMIHS). PMID: 24337657
    13. The R148S variant in ACTG2 as a cause of autosomal dominant familial visceral myopathy in one family. PMID: 22960657
    14. NOX4 and ROS have a role in myofibroblast differentiation and collagen and alpha-actin production of TGF- beta1-induced nasal polyp-derived fibroblasts. PMID: 22722757
    15. SMGA gene activity in prostate epithelia is due, in part, to the androgen-dependent expression of Nkx 3.1 PMID: 12450213
    16. It was suggested that peritubular alphaSMA-positive myofibroblastic cells, in collaboration with interstitial macrophages, contribute to the progression of interstitial fibrosis in diabetic nephropathy. PMID: 17009076
    17. TNF-alpha suppresses TGF-beta1-induced myofibroblast (fibroproliferative) phenotypic genes, for example, alpha-SMA, collagen type 1A, and fibronectin at the mRNA level. PMID: 17554369
    18. The insertion-deletion polymorphism in intron 1 of the gamma 2 actin gene is unlikely to play any significant role in obstetric cholestasis or preeclampsia in patients from eastern Finland. PMID: 17934296
    19. MYOCD can discriminate among several juxtaposed CArG elements, presumably through its novel partnership with NKX3.1, to optimally transactivate the human ACTG2 promoter PMID: 19797053

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Visceral myopathy (VSCM)
  • 亞細胞定位:
    Cytoplasm, cytoskeleton.
  • 蛋白家族:
    Actin family
  • 數據庫鏈接:

    HGNC: 145

    OMIM: 102545

    KEGG: hsa:72

    STRING: 9606.ENSP00000295137

    UniGene: Hs.516105



主站蜘蛛池模板: 久久精品一区二区三区四区| 国产乱子伦在线一区二区| 无码乱人伦一区二区亚洲| 髙清国产性猛交xxxand| 国产艳妇av在线出轨| 国产麻豆精品福利在线| 国产精品一区二区 尿失禁| 免费久久人人爽人人爽av| 日本成熟老妇乱| 做性久久久久久| 亚洲色大成网站www久久九九 | 精品人妻av区乱码| 永久免费精品精品永久-夜色| 亚洲欧美日韩国产另类电影| 久久人人做人人妻人人玩精品va| 午夜男女爽爽影院免费视频下载| 成人欧美一区在线视频| 美国特级a毛片免费网站| 国产偷国产偷亚洲清高app| 亚洲精品456在线播放| 女人爽到喷水的视频大全| 国产女主播白浆在线看| 精品国产天线2019| 色欲欲www成人网站| 国产婷婷亚洲999精品小说| 中文字幕久久精品一区二区三区 | 精品国产第一福利网站| 欧美日韩在线视频一区| 亚洲精品亚洲人成在线| 天天综合色天天综合色h| 欧美人妻少妇精品久久黑人 | 性色欲情网站iwww| 亚洲色婷婷婷婷五月基地| 99久久伊人精品综合观看| 亚洲免费观看在线视频| 国产精品欧美福利久久| 欧美日韩国产专区一区二区 | 精品久久久久久中文字幕| 欧美激情一区二区成人| 中文字幕无码av免费久久| 中文乱码字慕人妻熟女人妻 |