在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ACTG2 Antibody, Biotin conjugated

  • 中文名稱:
    ACTG2兔多克隆抗體, Biotin偶聯(lián)
  • 貨號:
    CSB-PA12799D0Rb
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) ACTG2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    ACT antibody; ACTA3 antibody; ACTE antibody; ACTG2 antibody; ACTH_HUMAN antibody; Actin antibody; Actin gamma 2 smooth muscle enteric antibody; Actin gamma enteric smooth muscle antibody; Actin like protein antibody; ACTL3 antibody; ACTSG antibody; Alpha actin 3 antibody; Alpha-actin-3 antibody; Gamma 2 actin antibody; Gamma-2-actin antibody; gamma-enteric smooth muscle antibody; Smooth muscle gamma actin antibody; Smooth muscle gamma-actin antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Actin, gamma-enteric smooth muscle protein (181-376AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
  • 基因功能參考文獻(xiàn):
    1. fetus with intestinal pseudo-obstruction heterozygous for p.R63G pathogenic variant (NM_001615.3 c.187C>G; rs864309491) in exon 3 PMID: 29072330
    2. Whole exome and Sanger sequencing revealed a pathogenic variant in the ACTG2 gene in 4 out of 28 probands with chronic intestinal pseudo-obstruction and megacystis. Moreover, a mutational hotspot in the ACTG2 gene was recognized. Genetic heterogeneity is evident. PMID: 28422808
    3. R257 variant in the ACTG2 appear to be more frequent in populations of Asian ancestry; mutation of this locus could cause alterations of the intestinal and bladder smooth muscle filaments. PMID: 27007401
    4. ACTG2 boosts the metastatic potential of hepatocellular carcinoma in a Notch1-dependent manner. PMID: 28385530
    5. Missense variants in ACTG2 were identified in the patients with either megacystis-microcolon-intestinal hypoperistalsis syndrome or intestinal pseudo-obstruction. PMID: 26813947
    6. A heterozygous missense variant in ACTG2 was identified that impaired actin polymerization in sporadic Megacystis microcolon intestinal hypoperistalsis syndrome. PMID: 26647307
    7. ACTG2 is expressed in a fraction of small intestinal neuroendocrine tumors, can inhibit cell growth in vitro, and is positively regulated by miR-145. PMID: 27107594
    8. Mutations within ACTG2 are associated with fetal megacystis in microcolon intestinal hypoperistalsis syndrome. PMID: 25998219
    9. Phenotypic spectrum of ACTG2 missense variants involved severe pathology in multiple smooth muscle-dependent organs including the biliary tract and the uterus in the family with visceral myopathy. PMID: 25782675
    10. gammaSMA expression in hepatocellular carcinoma is strongly correlated with the EMT process, HCC aggressiveness and the identification of cancer stem cells PMID: 26110787
    11. ACTG2 encodes g2 enteric actin and is the first gene to be clearly associated with Megacystis-microcolon-intestinal hypoperistalsis syndrome, suggesting an important role for contractile proteins in enteric smooth muscle disease. PMID: 24676022
    12. Two novel mutations in the ACTG2 gene, p.R178L and p.R178C, have been identified in two unrelated children with congenital distended bladder, microcolon, and intestinal hypoperistalsis (MMIHS). PMID: 24337657
    13. The R148S variant in ACTG2 as a cause of autosomal dominant familial visceral myopathy in one family. PMID: 22960657
    14. NOX4 and ROS have a role in myofibroblast differentiation and collagen and alpha-actin production of TGF- beta1-induced nasal polyp-derived fibroblasts. PMID: 22722757
    15. SMGA gene activity in prostate epithelia is due, in part, to the androgen-dependent expression of Nkx 3.1 PMID: 12450213
    16. It was suggested that peritubular alphaSMA-positive myofibroblastic cells, in collaboration with interstitial macrophages, contribute to the progression of interstitial fibrosis in diabetic nephropathy. PMID: 17009076
    17. TNF-alpha suppresses TGF-beta1-induced myofibroblast (fibroproliferative) phenotypic genes, for example, alpha-SMA, collagen type 1A, and fibronectin at the mRNA level. PMID: 17554369
    18. The insertion-deletion polymorphism in intron 1 of the gamma 2 actin gene is unlikely to play any significant role in obstetric cholestasis or preeclampsia in patients from eastern Finland. PMID: 17934296
    19. MYOCD can discriminate among several juxtaposed CArG elements, presumably through its novel partnership with NKX3.1, to optimally transactivate the human ACTG2 promoter PMID: 19797053

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Visceral myopathy (VSCM)
  • 亞細(xì)胞定位:
    Cytoplasm, cytoskeleton.
  • 蛋白家族:
    Actin family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 145

    OMIM: 102545

    KEGG: hsa:72

    STRING: 9606.ENSP00000295137

    UniGene: Hs.516105



主站蜘蛛池模板: 国产午夜av秒播在线观看| 人人揉揉揉香蕉大免费| 中文字幕人妻高清乱码| 欧美精品一区二区精品久久| 色欲综合久久躁天天躁蜜桃| 国产精品永久免费视频| 欧美黑人乱大交| 午夜内射中出视频| 精品三级av无码一区| 国产精品人成视频免费999| 精品一品国产午夜福利视频| 欧美日产亚洲国产精品| 无码人妻精品一区二区三区东京热 | 鲁一鲁一鲁一鲁一曰综合网| 男女车车的车车网站w98免费| 国产精品免费观看久久| 精品女同一区二区| 另类亚洲小说图片综合区| 在线观看麻豆国产成人av在线播放 | 亚洲综合色无码| 欧美性猛交xxxx三人| 国内揄拍国内精品人妻| 隔壁邻居是巨爆乳寡妇| 国产女人乱人伦精品一区二区| 国产丰满麻豆vⅰde0sex| 亚洲精品无码一二区a片| 国产精品成人免费一区久久羞羞| 国产精品一久久香蕉国产线看观看 | av无码天堂一区二区三区| 国产亚洲欧美另类一区二区| 精品国产乱码久久久久久鸭王1| 亚洲精品无码久久久| 亚洲中文无码人a∨在线| 韩国无码色视频在线观看| 久久精品日日躁夜夜躁欧美| 日韩乱码人妻无码中文字幕视频 | 女人和拘做爰正片视频| 少妇被爽到高潮动态图| 熟妇人妻中文字幕无码老熟妇| 小嫩妇好紧好爽18禁视频| 成人综合网亚洲伊人|