在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ABCD4 Antibody

ABCD4 Antibody

  • 中文名稱：
    ABCD4兔多克隆抗體
  • 貨號：
    CSB-PA001075LA01HU
  • 規格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA001075LA01HU diluted at 1:100 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) ABCD4 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ABCD4
  • 別名：
    ABCD4; PXMP1L; Lysosomal cobalamin transporter ABCD4; ATP-binding cassette sub-family D member 4; PMP70-related protein; P70R; Peroxisomal membrane protein 1-like; PXMP1-L; Peroxisomal membrane protein 69; PMP69
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human ATP-binding cassette sub-family D member 4 protein (335-606AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，ABCD4 Antibody (CSB-PA001075LA01HU)，的標記方式是Non-conjugated。對于ABCD4 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA001075LB01HU ABCD4 Antibody, HRP conjugated ELISA
    FITC CSB-PA001075LC01HU ABCD4 Antibody, FITC conjugated
    Biotin CSB-PA001075LD01HU ABCD4 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Lysosomal membrane protein that transports cobalamin (Vitamin B12) from the lysosomal lumen to the cytosol in an ATP-dependent manner. Targeted by LMBRD1 lysosomal chaperone from the endoplasmic reticulum to the lysosomal membrane. Then forms a complex with lysosomal chaperone LMBRD1 and cytosolic MMACHC to transport cobalamin across the lysosomal membrane.
  • 基因功能參考文獻：
    1. endogenous ABCD4 was localized to both lysosomes and the ER, and its lysosomal localization was disturbed by knockout of LMBRD1 PMID: 27456980
    2. Data suggest that ABCD4 lysosomal targeting depends on co-expression of and interaction with LMBRD1; mutations in LMBRD1 and ABCD4 that result in cobalamin metabolism disorders cblF and cblJ (or mutations in ATPase domain) disrupt interactions between LMBRD1 and ABCD4. (LMBRD1 = nuclear export signal-interacting protein; ABCD4 = ATP-binding cassette, sub-family D (ALD), member 4) PMID: 28572511
    3. Results propose a model whereby membrane-bound LMBD1 and ABCD4 facilitate the vectorial delivery of lysosomal vitamin B12 to cytoplasmic MMACHC. PMID: 25535791
    4. mutations altering the putative ATPase domain of ABCD4 affect its function, suggesting that the ATPase activity of ABCD4 may be involved in intracellular processing of vitamin B12. PMID: 22922874
    5. Defects in ABCB4 have been found to cause progressive familial intrahepatic cholestasis type 3. PMID: 21514256
    6. expression tends to be correlated with the severity of X-linked adrenoleukodystrophy PMID: 15800013

    顯示更多

    收起更多

  • 相關疾病：
    Methylmalonic aciduria and homocystinuria type cblJ (MAHCJ)
  • 亞細胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
  • 蛋白家族：
    ABC transporter superfamily, ABCD family, Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily
  • 組織特異性：
    Ubiquitous.
  • 數據庫鏈接：

    HGNC: 68

    OMIM: 603214

    KEGG: hsa:5826

    STRING: 9606.ENSP00000349396

    UniGene: Hs.94395



主站蜘蛛池模板： 亚欧无线一线二线三线区别| 亚洲欧洲精品成人久久曰| 乱人伦人妻中文字幕| 亚洲国产高清av网站| 97se狼狼狼狼狼亚洲网| 人妻精品动漫h无码中字| 国产欠欠欠18一区二区| 大陆精大陆国产国语精品 | 99热亚洲色精品国产88| 国产福利永久在线视频无毒不卡 | 99re久久精品国产| 欧美大黑帍在线播放| 性中国妓女毛茸茸视频| 国产无套露脸在线观看| 国产精品99精品无码视亚| 国产亚洲欧美另类一区二区| 18禁无遮挡肉动漫在线播放观看| 欧美牲交a欧美牲交aⅴ| 动漫精品啪啪一区二区三区| 在线看片无码永久免费视频| 亚洲不卡1卡2卡三卡入口| 亚洲色大成网站www久久九| 97国产精东麻豆人妻电影| 久久精品成人免费国产片小草| 免费观看又色又爽又湿的软件| 成人性生交大片免费看视频app| 四虎亚洲欧美成人网站| 欧洲无线码免费一区| 少妇仑乱a毛片| 好爽…又高潮了免费毛片| 樱花草在线社区www日本影院| 日韩吃奶摸下aa片免费观看| 蜜芽久久人人超碰爱香蕉| 一本一道波多野结衣av黑人| 麻豆果冻国产剧情av在线播放| 国产av丝袜一区二区三区| 国产在线无码一区二区三区视频| 国产无套内射又大又猛又粗又爽| 少妇扒开双腿让我看个够| 亚洲中久无码永久在线观看同| 国产又色又爽又黄又免费软件 |