在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ABCD4 Antibody

ABCD4 Antibody

  • 中文名稱(chēng)：
    ABCD4兔多克隆抗體
  • 貨號(hào)：
    CSB-PA039868
  • 規(guī)格：
    ￥1100
  • 圖片：
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Jurkat cells, Primary antibody: CSB-PA039868(ABCD4 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    ABCD4
  • 別名：
    ABCD4; PXMP1L; Lysosomal cobalamin transporter ABCD4; ATP-binding cassette sub-family D member 4; PMP70-related protein; P70R; Peroxisomal membrane protein 1-like; PXMP1-L; Peroxisomal membrane protein 69; PMP69
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human ABCD4
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Lysosomal membrane protein that transports cobalamin (Vitamin B12) from the lysosomal lumen to the cytosol in an ATP-dependent manner. Targeted by LMBRD1 lysosomal chaperone from the endoplasmic reticulum to the lysosomal membrane. Then forms a complex with lysosomal chaperone LMBRD1 and cytosolic MMACHC to transport cobalamin across the lysosomal membrane.
  • 基因功能參考文獻(xiàn)：
    1. endogenous ABCD4 was localized to both lysosomes and the ER, and its lysosomal localization was disturbed by knockout of LMBRD1 PMID: 27456980
    2. Data suggest that ABCD4 lysosomal targeting depends on co-expression of and interaction with LMBRD1; mutations in LMBRD1 and ABCD4 that result in cobalamin metabolism disorders cblF and cblJ (or mutations in ATPase domain) disrupt interactions between LMBRD1 and ABCD4. (LMBRD1 = nuclear export signal-interacting protein; ABCD4 = ATP-binding cassette, sub-family D (ALD), member 4) PMID: 28572511
    3. Results propose a model whereby membrane-bound LMBD1 and ABCD4 facilitate the vectorial delivery of lysosomal vitamin B12 to cytoplasmic MMACHC. PMID: 25535791
    4. mutations altering the putative ATPase domain of ABCD4 affect its function, suggesting that the ATPase activity of ABCD4 may be involved in intracellular processing of vitamin B12. PMID: 22922874
    5. Defects in ABCB4 have been found to cause progressive familial intrahepatic cholestasis type 3. PMID: 21514256
    6. expression tends to be correlated with the severity of X-linked adrenoleukodystrophy PMID: 15800013

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Methylmalonic aciduria and homocystinuria type cblJ (MAHCJ)
  • 亞細(xì)胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
  • 蛋白家族：
    ABC transporter superfamily, ABCD family, Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily
  • 組織特異性：
    Ubiquitous.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 68

    OMIM: 603214

    KEGG: hsa:5826

    STRING: 9606.ENSP00000349396

    UniGene: Hs.94395



主站蜘蛛池模板： 久久99国产精品久久99果冻传媒 | 亚洲中文字幕婷婷在线| 亚洲日韩看片成人无码| 亚洲熟妇av综合网五月| 无码人妻丝袜在线视频| 午夜精品久久久久久久久久久久| 国产玉足脚交极品在线播放| 国产av偷闻女邻居内裤被发现| 亚洲中文字幕无码久久| 国产午国产午夜精华 免费| 亚洲成av人在线视猫咪| 久久国内精品自在自线图片| 中文字幕被公侵犯的漂亮人妻| 亚洲欧美丝袜精品久久| 国产一二三四区乱码免费| 午夜爱爱爱爱爽爽爽网站| 在线看亚洲十八禁网站| 米奇影视第四色| 国产精品美脚玉足脚交欧美| 四虎国产精品永久免费网址| 国产精品国产成人国产三级 | 亚洲中文字幕a∨在线| 中文字幕亚洲综合久久菠萝蜜| 狠狠色综合7777久夜色撩人| 国内久久婷婷五月综合色| 亚洲午夜久久久无码精品网红a片 国产亚洲日韩一区二区三区 | 久久久肥妇熟女ⅹxxx毛片| 草草久久久无码国产专区| www夜片内射视频日韩精品成人| 亚洲日韩看片成人无码| 成人国产精品一区二区免费看| 成熟老妇女毛茸茸的做性| 日韩a∨精品日韩在线观看| 无码人妻精品中文字幕| 亚洲 自拍 色综合图区av| 97夜夜澡人人爽人人| 人妻无码久久久久久久久久久| 熟睡中被义子侵犯在线播放| 国产网曝门亚洲综合在线| 77777_亚洲午夜久久多人| 久久精品国产99国产精偷|