在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ABCD2 Antibody, HRP conjugated

ABCD2 Antibody, HRP conjugated

  • 中文名稱：
    ABCD2兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA866202LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) ABCD2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ABCD2
  • 別名：
    ABCD2; ALD1; ALDL1; ALDR; ALDRP; ATP-binding cassette sub-family D member 2; Adrenoleukodystrophy-like 1; Adrenoleukodystrophy-related protein; hALDR
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human ATP-binding cassette sub-family D member 2 protein (559-715AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen. Like ABCD1 seems to have fatty acyl-CoA thioesterase (ACOT) and ATPase activities, according to this model, VLCFA-CoA as free VLCFA is transpoted in an ATP-dependent manner into peroxisomes after the hydrolysis of VLCFA-CoA mediated by the ACOT activity of ABCD2 (Probable). Shows overlapping substrate specificities with ABCD1 toward saturated fatty acids (FA) and monounsaturated FA (MUFA) but has a distinct substrate preference for shorter VLCFA (C22:0) and polyunsaturated fatty acid (PUFA) such as C22:6-CoA and C24:6-CoA (in vitro). Thus, may play a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation.
  • 基因功能參考文獻：
    1. The functional integrity of ABCD2 may play an important role in OA pathogenesis via the accumulation of VLCFAs and stimulation of apoptotic death through altering profiles of miRNAs that target ACSL4. PMID: 30264402
    2. 13-cis-retinoic acid induces ABCD2 expression in human monocytes/macrophages. PMID: 25079382
    3. ABCD2 has a role, but not a strong one, in risk of early recurrent events after transient ischemic attack PMID: 25604068
    4. results show that although patients with ABCD2 score greater than 4 were more likely to develop recurrent TIA/CVA in short term, those with lesser score still harbour a considerable risk for TIA/CVA PMID: 24338191
    5. The transcriptional activity of the ABCD2 promoter was strongly increased by ectopic expression of beta-catenin and TCF-4. PMID: 23437103
    6. LXRalpha is a negative modulator of Abcd2, acting through a novel regulatory mechanism involving overlapping SREBP and LXRalpha binding sites PMID: 16249184
    7. Testosterone metabolites increased expression of ABCD2 mRNA in fibroblasts from X-linked adrenoleukodystrophy patients. PMID: 17602313
    8. These findings are of particular importance for the attempt of pharmacological induction of ABCD2 as a possible therapeutic approach in X-linked adrenoleukodystrophy. PMID: 18834860
    9. LDRP (ABCD2) interacts with both farnesylated wild-type and farnesylation-deficient mutant PEX19. This interaction is mediated by amino acids 1-218 of ALDRP. PMID: 10777694
    10. ALDRP (ABCD2) homodimerizes via the C terminal half. This interaction is modelled on the demonstrated homodimerization of murine ALDRP (ABCD2). PMID: 10551832
    11. ALDRP interacts with PMP70. This interaction occurs via the ALDRP C-terminus [374-740] and the PMP70 C-terminus [338-659]. This interaction was demonstrated using human PMP70 and mouse ALDRP. PMID: 10551832
    12. ALDRP interacts with PEX19 splice variants PEX19-delta-E2 and PEX19-delta-E8. PMID: 11883941

    顯示更多

    收起更多

  • 亞細胞定位：
    Peroxisome membrane; Multi-pass membrane protein.
  • 蛋白家族：
    ABC transporter superfamily, ABCD family, Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily
  • 組織特異性：
    Predominantly expressed in brain and heart.
  • 數據庫鏈接：

    HGNC: 66

    OMIM: 601081

    KEGG: hsa:225

    STRING: 9606.ENSP00000310688

    UniGene: Hs.117852



主站蜘蛛池模板： 久久99精品久久久久婷婷暖| 久久久久国产精品人妻aⅴ四季| 另类国产精品一区二区| 亚洲成a人片在线观看的电影| 中文字幕人妻第一区| 成人午夜福利视频后入| 国产精品国产三级国产专区53| 么公的好大好硬好深好爽视频 | 欧美情侣性视频| 欧美顶级少妇作爱| 人人澡超碰碰97碰碰碰| 亚洲国产成人综合一区二区三区| 挺进邻居丰满少妇的身体| 欧美孕妇xxxx做受欧美88| 国产激情高中生呻吟视频 | 亚州久久久久区1区2少妇| 无码成人精品区在线观看| 髙清国产性猛交xxxand | 色一情一乱一伦一区二区三区小说| 做性久久久久久| 伊人久久大香线蕉成人| 国产成人精品一区二三区| 国精产品一品二品国精品69xx| 国产在线 | 欧洲| 成人无遮挡18禁免费视频| 国产欧美精品一区二区色综合 | 国产午夜片无码区在线观看爱情网| 欧美日韩视频在线第一区| 女女女女女裸体处开bbb| 十八18禁国产精品www| 国产成人麻豆精品午夜福利在线 | 成人夜色视频网站在线观看 | 亚洲欧美成人一区二区三区| 欧美乱妇狂野欧美在线视频| 久久香蕉综合色一综合色88| 免费人成网站在线视频| 内射白浆一区二区在线观看| 一个人在线观看免费中文www| 2021国产精品视频网站| 亚洲综合久久无码色噜噜| 无码成人精品区在线观看|