在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ABCD2 Antibody, FITC conjugated

ABCD2 Antibody, FITC conjugated

  • 中文名稱：
    ABCD2兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA866202LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) ABCD2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ABCD2
  • 別名：
    ABCD2; ALD1; ALDL1; ALDR; ALDRP; ATP-binding cassette sub-family D member 2; Adrenoleukodystrophy-like 1; Adrenoleukodystrophy-related protein; hALDR
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human ATP-binding cassette sub-family D member 2 protein (559-715AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen. Like ABCD1 seems to have fatty acyl-CoA thioesterase (ACOT) and ATPase activities, according to this model, VLCFA-CoA as free VLCFA is transpoted in an ATP-dependent manner into peroxisomes after the hydrolysis of VLCFA-CoA mediated by the ACOT activity of ABCD2 (Probable). Shows overlapping substrate specificities with ABCD1 toward saturated fatty acids (FA) and monounsaturated FA (MUFA) but has a distinct substrate preference for shorter VLCFA (C22:0) and polyunsaturated fatty acid (PUFA) such as C22:6-CoA and C24:6-CoA (in vitro). Thus, may play a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation.
  • 基因功能參考文獻(xiàn)：
    1. The functional integrity of ABCD2 may play an important role in OA pathogenesis via the accumulation of VLCFAs and stimulation of apoptotic death through altering profiles of miRNAs that target ACSL4. PMID: 30264402
    2. 13-cis-retinoic acid induces ABCD2 expression in human monocytes/macrophages. PMID: 25079382
    3. ABCD2 has a role, but not a strong one, in risk of early recurrent events after transient ischemic attack PMID: 25604068
    4. results show that although patients with ABCD2 score greater than 4 were more likely to develop recurrent TIA/CVA in short term, those with lesser score still harbour a considerable risk for TIA/CVA PMID: 24338191
    5. The transcriptional activity of the ABCD2 promoter was strongly increased by ectopic expression of beta-catenin and TCF-4. PMID: 23437103
    6. LXRalpha is a negative modulator of Abcd2, acting through a novel regulatory mechanism involving overlapping SREBP and LXRalpha binding sites PMID: 16249184
    7. Testosterone metabolites increased expression of ABCD2 mRNA in fibroblasts from X-linked adrenoleukodystrophy patients. PMID: 17602313
    8. These findings are of particular importance for the attempt of pharmacological induction of ABCD2 as a possible therapeutic approach in X-linked adrenoleukodystrophy. PMID: 18834860
    9. LDRP (ABCD2) interacts with both farnesylated wild-type and farnesylation-deficient mutant PEX19. This interaction is mediated by amino acids 1-218 of ALDRP. PMID: 10777694
    10. ALDRP (ABCD2) homodimerizes via the C terminal half. This interaction is modelled on the demonstrated homodimerization of murine ALDRP (ABCD2). PMID: 10551832
    11. ALDRP interacts with PMP70. This interaction occurs via the ALDRP C-terminus [374-740] and the PMP70 C-terminus [338-659]. This interaction was demonstrated using human PMP70 and mouse ALDRP. PMID: 10551832
    12. ALDRP interacts with PEX19 splice variants PEX19-delta-E2 and PEX19-delta-E8. PMID: 11883941

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Peroxisome membrane; Multi-pass membrane protein.
  • 蛋白家族：
    ABC transporter superfamily, ABCD family, Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily
  • 組織特異性：
    Predominantly expressed in brain and heart.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 66

    OMIM: 601081

    KEGG: hsa:225

    STRING: 9606.ENSP00000310688

    UniGene: Hs.117852



主站蜘蛛池模板： 国产在线拍揄自揄拍免费下载| 亚洲成a人片在线观看天堂无码| 精品人妻少妇一区二区| 亚洲精品一区三区三区在线观看| 国产乱码精品一品二品| 国产午夜福利100集发布| 正在播放东北夫妻内射| 中国国产免费毛卡片| 欧美成人精品一区二区综合a片| 久九九精品免费视频| 国产成人综合久久精品| 午夜精品久久久久久久| 日韩亚洲欧美中文在线| 性欧美性另类巨大| 国产成人亚洲综合无码品善网| 国产成人精品午夜福利不卡| 日韩内射美女人妻一区二区三区| 亚洲已满18点击进入在线看片| 久久九九精品99国产精品 | 九九久久精品无码专区| 国产精品国产三级国产a| 337p人体 欧洲人体 亚洲 | 亚洲中文无码人a∨在线导航| 成 人 社区在线视频| 4hu亚洲人成人无码网www电影首页 | 亚洲午夜国产精品无码老牛影视| 成在人线av无码免观看午夜网| 亚洲高清专区日韩精品| 在线黑人抽搐潮喷| 中文字幕亚洲无线码在线一区| 国模小婕私拍鲜嫩玉门| 人人狠狠久久亚洲综合88| 国产日韩欧美不卡在线二区| av片在线观看| 中文字幕乱码免费看电影| 日本精品αv中文字幕| 狠狠色噜噜狠狠狠狠米奇777 | 24小时日本在线www免费的| 女人的天堂a国产在线观看| 亚洲精品av一区午夜福利| 无码中文字幕日韩专区视频 |