在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

AATF Antibody

  • 中文名稱:
    AATF兔多克隆抗體
  • 貨號:
    CSB-PA05264A0Rb
  • 規格:
    ¥440
  • 圖片:
    • IHC image of CSB-PA05264A0Rb diluted at 1:200 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) AATF Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    AATF antibody; AATF_HUMAN antibody; Apoptosis antagonizing transcription factor antibody; Apoptosis-antagonizing transcription factor antibody; BFR2 antibody; CHE 1 antibody; CHE1 antibody; DED antibody; Protein AATF antibody; Rb binding protein Che 1 antibody; Rb-binding protein Che-1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Protein AATF protein (6-294AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,AATF Antibody (CSB-PA05264A0Rb),的標記方式是Non-conjugated。對于AATF Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA05264B0Rb AATF Antibody, HRP conjugated ELISA
    FITC CSB-PA05264C0Rb AATF Antibody, FITC conjugated
    Biotin CSB-PA05264D0Rb AATF Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.
  • 基因功能參考文獻:
    1. Results show that Che-1 protects colon cancer cells from apoptosis induced by hypoxia through its ability to regulate HIF1-alpha stabilization in colorectal cancer cells. PMID: 28214471
    2. Results show that eEF1Bgamma binds to the Che-1 promoter region and its transcript, and describe a novel mitochondrial localization for the Che-1 protein which needs mitochondrial integrity for correct localization. PMID: 27639846
    3. we identified the ANN complex as a novel functional module supporting the nucleolar maturation of 40S ribosomal subunits. Our data help to explain the described role of AATF in cell proliferation during mouse development as well as its requirement for malignant tumor growth. PMID: 27599843
    4. the effect of APOBEC3G over-expression upon AATF gene expression, was examined. PMID: 27611213
    5. loss of Che-1 inhibits proliferation and promotes apoptosis in MG-63 cells by decreasing the level of mutant p53 PMID: 27012205
    6. It was concluded that PARP-1 was involved in the DNA damage repair induced by HQ via increasing the accumulation of apoptosis antagonizing transcription factor through PARylation. PMID: 26822515
    7. These results confirm Che-1 as an important regulator of p53 activity and suggest Che-1 to be a promising yet attractive drug target for cancer therapy. PMID: 25996291
    8. In the face of high glucose threat, mitochondrial UCP2 gene expression is regulated by miR-2909 and AATF. PMID: 25976474
    9. This mutant AATF along with its interactome consisting of SP1, DNMT3B and Par-4 ensures cancer cell DNA methylation required for down-regulation of tumor suppressor genes. PMID: 25231211
    10. HIPK2 depletion strongly decreases Che-1 ubiquitylation and degradation. PMID: 25210797
    11. Che-1 expression correlates with the progression of multiple myeloma and is required for cell growth and survival.Che-1 controls mTOR through the induction of Redd1 and Deptor, two important repressors of mTOR. PMID: 25770584
    12. Cell proliferation decreased by 41% which was accompanied by apoptosis induction in 30% MCF-7 cells after AATF gene knockdown. PMID: 23801113
    13. Che-1 depletion abolishes the ability of Chk1 to bind pericentrin and to localize at centrosomes, which, in its turn, deregulates the activation of centrosomal cyclin B-Cdk1 and advances entry into mitosis. PMID: 23798705
    14. These results identify AATF as a nucleolar-confined c-Jun cofactor whose expression levels and spatial distribution determine the stress-induced activity of c-Jun and the levels of c-Jun-mediated apoptosis. PMID: 22933572
    15. Nuclear AATF enrichment is selected for in p53-proficient endometrial cancers. Focal copy number AATF gains correlate with reduced overall survival in neuroblastoma. AATF is a critical repressor of p53-driven apoptosis. PMID: 22909821
    16. found that Che-1 is required for sustaining mutant p53 expression in several cancer cell lines, and that Che-1 depletion by siRNA induces apoptosis both in vitro and in vivo PMID: 20708154
    17. No evidence for the association of mutations with breast cancer was observed. PMID: 20025740
    18. Che-1 affects cell growth by interfering with the recruitment of HDAC1 by retinoblastoma protein. Che-1 overexpression activates DNA synthesis in quiescent NIH-3T3 cells through HFDAC1 displacement. PMID: 12450794
    19. Che-1 can be considered a general HDAC1 competitor and its down-regulation is involved in colon carcinoma cell proliferation PMID: 12847090
    20. apoptosis-antagonizing transcription factor binds to TSG101 in a process that enhances androgen receptor-mediated transcription by promoting its monoubiquitination PMID: 14761944
    21. AATF gene may be of crucial importance in maintaining the leukemic state of a cell compartment through its ability to initiate cell proliferation coupled with repression of cellular apoptosis. PMID: 17006618
    22. Che-1 as a new Pin1 and HDM2 target and confirm its important role in the cellular response to DNA damage. PMID: 17468107
    23. Che-1 interacts with NRAGE and NRAGE overexpression downregulates endogenous Che-1 by targeting it for proteasome-dependent degradation. PMID: 17488777
    24. This review explains the novel miRNA encoded exclusively by HIV-1 genome that has the ability to specifically target cellular AATF gene known to play a crucial role in the maintenance of adaptive immunity at nucleic acid level against HIV-1 invasion. PMID: 18341201

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus, nucleolus.
  • 蛋白家族:
    AATF family
  • 組織特異性:
    Ubiquitously expressed. Expressed at high levels in brain, heart, kidney, placenta and thymus.
  • 數據庫鏈接:

    HGNC: 19235

    OMIM: 608463

    KEGG: hsa:26574

    STRING: 9606.ENSP00000225402

    UniGene: Hs.195740



主站蜘蛛池模板: 成人无码www在线看免费| 亚洲区小说区图片区qvod| 国产精品特级毛片一区二区三区| 欧美成人a在线网站| 欧美激情综合五月色丁香 | 亚洲熟妇色自偷自拍另类| 亚洲欧美日韩综合久久久| 亚洲高潮喷水无码av电影| 久久久久人妻一区视色| 四虎影视在线影院在线观看免费视频| 精品国精品国产自在久国产应用| 九九热在线视频观看这里只有精品| 日本人妻伦在线中文字幕| 久久青青草原国产精品最新片| 亚洲欧美在线观看品| 久久精品水蜜桃av综合天堂| 国产精品99久久精品爆乳 | 一区二区三区在线 | 欧洲| 精品亚洲一区二区三区四区五区 | 奶头又大又白喷奶水av| 久久人人爽人人爽人人片| 性夜影院午夜看片| 国色天香国产精品| 丝袜美腿亚洲一区二区| 亚洲 欧美 国产 日韩 中文字幕| 国模裸体无码xxxx视频| 国产女人高潮抽搐叫床视频| 国产产品亚洲产品| 国产日韩一区二区三免费高清| 色播亚洲视频在线观看| 亚洲成a人v欧美综合天堂下载| 青青视频免费观看免费| 内射极品少妇xxxxxhd| h无码动漫在线观看| 青青草国产三级精品三级| 男人添女人囗交做爰视频| 少妇下蹲露大唇无遮挡| 久久久久久成人综合网| 国产真实的和子乱拍在线观看| 国产免费艾彩sm调教视频| 久无码久无码av无码|