在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

AATF Antibody

  • 中文名稱:
    AATF兔多克隆抗體
  • 貨號:
    CSB-PA001612
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of HuvEc cells using Che-1 Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    AATF antibody; AATF_HUMAN antibody; Apoptosis antagonizing transcription factor antibody; Apoptosis-antagonizing transcription factor antibody; BFR2 antibody; CHE 1 antibody; CHE1 antibody; DED antibody; Protein AATF antibody; Rb binding protein Che 1 antibody; Rb-binding protein Che-1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the N-terminal region of Human Che-1.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.
  • 基因功能參考文獻:
    1. Results show that Che-1 protects colon cancer cells from apoptosis induced by hypoxia through its ability to regulate HIF1-alpha stabilization in colorectal cancer cells. PMID: 28214471
    2. Results show that eEF1Bgamma binds to the Che-1 promoter region and its transcript, and describe a novel mitochondrial localization for the Che-1 protein which needs mitochondrial integrity for correct localization. PMID: 27639846
    3. we identified the ANN complex as a novel functional module supporting the nucleolar maturation of 40S ribosomal subunits. Our data help to explain the described role of AATF in cell proliferation during mouse development as well as its requirement for malignant tumor growth. PMID: 27599843
    4. the effect of APOBEC3G over-expression upon AATF gene expression, was examined. PMID: 27611213
    5. loss of Che-1 inhibits proliferation and promotes apoptosis in MG-63 cells by decreasing the level of mutant p53 PMID: 27012205
    6. It was concluded that PARP-1 was involved in the DNA damage repair induced by HQ via increasing the accumulation of apoptosis antagonizing transcription factor through PARylation. PMID: 26822515
    7. These results confirm Che-1 as an important regulator of p53 activity and suggest Che-1 to be a promising yet attractive drug target for cancer therapy. PMID: 25996291
    8. In the face of high glucose threat, mitochondrial UCP2 gene expression is regulated by miR-2909 and AATF. PMID: 25976474
    9. This mutant AATF along with its interactome consisting of SP1, DNMT3B and Par-4 ensures cancer cell DNA methylation required for down-regulation of tumor suppressor genes. PMID: 25231211
    10. HIPK2 depletion strongly decreases Che-1 ubiquitylation and degradation. PMID: 25210797
    11. Che-1 expression correlates with the progression of multiple myeloma and is required for cell growth and survival.Che-1 controls mTOR through the induction of Redd1 and Deptor, two important repressors of mTOR. PMID: 25770584
    12. Cell proliferation decreased by 41% which was accompanied by apoptosis induction in 30% MCF-7 cells after AATF gene knockdown. PMID: 23801113
    13. Che-1 depletion abolishes the ability of Chk1 to bind pericentrin and to localize at centrosomes, which, in its turn, deregulates the activation of centrosomal cyclin B-Cdk1 and advances entry into mitosis. PMID: 23798705
    14. These results identify AATF as a nucleolar-confined c-Jun cofactor whose expression levels and spatial distribution determine the stress-induced activity of c-Jun and the levels of c-Jun-mediated apoptosis. PMID: 22933572
    15. Nuclear AATF enrichment is selected for in p53-proficient endometrial cancers. Focal copy number AATF gains correlate with reduced overall survival in neuroblastoma. AATF is a critical repressor of p53-driven apoptosis. PMID: 22909821
    16. found that Che-1 is required for sustaining mutant p53 expression in several cancer cell lines, and that Che-1 depletion by siRNA induces apoptosis both in vitro and in vivo PMID: 20708154
    17. No evidence for the association of mutations with breast cancer was observed. PMID: 20025740
    18. Che-1 affects cell growth by interfering with the recruitment of HDAC1 by retinoblastoma protein. Che-1 overexpression activates DNA synthesis in quiescent NIH-3T3 cells through HFDAC1 displacement. PMID: 12450794
    19. Che-1 can be considered a general HDAC1 competitor and its down-regulation is involved in colon carcinoma cell proliferation PMID: 12847090
    20. apoptosis-antagonizing transcription factor binds to TSG101 in a process that enhances androgen receptor-mediated transcription by promoting its monoubiquitination PMID: 14761944
    21. AATF gene may be of crucial importance in maintaining the leukemic state of a cell compartment through its ability to initiate cell proliferation coupled with repression of cellular apoptosis. PMID: 17006618
    22. Che-1 as a new Pin1 and HDM2 target and confirm its important role in the cellular response to DNA damage. PMID: 17468107
    23. Che-1 interacts with NRAGE and NRAGE overexpression downregulates endogenous Che-1 by targeting it for proteasome-dependent degradation. PMID: 17488777
    24. This review explains the novel miRNA encoded exclusively by HIV-1 genome that has the ability to specifically target cellular AATF gene known to play a crucial role in the maintenance of adaptive immunity at nucleic acid level against HIV-1 invasion. PMID: 18341201

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus, nucleolus.
  • 蛋白家族:
    AATF family
  • 組織特異性:
    Ubiquitously expressed. Expressed at high levels in brain, heart, kidney, placenta and thymus.
  • 數據庫鏈接:

    HGNC: 19235

    OMIM: 608463

    KEGG: hsa:26574

    STRING: 9606.ENSP00000225402

    UniGene: Hs.195740



主站蜘蛛池模板: 欧美性猛交xxxx免费看蜜桃| 在线亚洲97se亚洲综合在线| 色视频www在线播放国产人成| 爱做久久久久久| 中文日韩亚洲欧美制服| 亚洲精品无码久久毛片波多野吉衣| 国产免费网站看v片在线无遮挡| 国产suv精品一区二区69| 无码一区二区三区中文字幕| 成人国产精品无码网站| 亚洲欧美午夜理论电影在线观看| 色天使久久综合网天天| 日韩人妻无码一区二区三区99| 亚洲中文字幕在线观看| 色综合色综合久久综合频道88| 草草影院精品一区二区三区| 亚洲欲色欲香天天综合网 | 中国内地毛片免费高清| 国产午夜大地久久| 他用舌头给我高潮喷水在线| 亚洲成av人片天堂网无码】| 色老板精品视频在线观看| 欧美亚洲一区二区三区| 西西人体大胆啪啪实拍| 免费午夜福利不卡片在线播放| 国产精品丝袜黑色高跟鞋| 高h猛烈失禁潮喷无码视频| 亚洲午夜成人精品无码app| 国产亚洲综合区成人国产系列| 欧美肥胖老妇bbw| 亚洲精品人成网线在线播放va| 天堂va欧美ⅴa亚洲va在线| av天堂午夜精品一区| 青春草在线视频免费观看| 不卡av中文字幕手机看| 少妇性荡欲午夜性开放视频剧场| 欧美性大战久久久久久| 国产性―交―乱―色―情人| 国产av天堂亚洲国产av天堂| 中文天堂在线www| 超级碰97直线国产免费公开|