在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

AANAT Antibody

  • 中文名稱:
    AANAT兔多克隆抗體
  • 貨號:
    CSB-PA179815
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA179815(AANAT Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA179815(AANAT Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    AANAT
  • 別名:
    AA-NAT antibody; Aanat antibody; Aralkylamine N-acetyltransferase antibody; Arylalkylamine N acetyltransferase antibody; Serotonin acetylase antibody; Serotonin N-acetyltransferase antibody; SNAT antibody; SNAT_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Fusion protein of Human AANAT
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.
  • 基因功能參考文獻:
    1. Aggregate genetic variation in circadian rhythm and melatonin pathways were significantly associated with the risk of prostate cancer in data combining GAME-ON and PLCO, after Bonferroni correction (ppathway < 0.00625). The two most significant genes were NPAS2 (pgene = 0.0062) and AANAT (pgene = 0.00078); the latter being significant after Bonferroni correction. PMID: 28699174
    2. Data show that arylalkymine N-acetyltransferase (AANAT) levels and melatonin synthesis change after transient receptor potential channel 4 (TRPV4 channel) stimulation in ciliary body epithelial cells. PMID: 28368307
    3. these and related results indicate both a major involvement of the N-end rule pathway in the control of rodent AANATs and substantial differences in the regulation of rodent and human AANATs that stem from differences in their N-terminal sequences. PMID: 27339900
    4. There is dysregulation of the AANAT/ASMT/melatonin --> melatonin receptor axis in cholangiocarcinoma, which inhibited melatonin secretion and subsequently enhanced CCA growth. PMID: 21778461
    5. The expression of AANAT in epithelial cells of striated ducts in human submandibular glands. PMID: 21437622
    6. The functional expression of human SNA protein was closely associated with the elevated synthesis of N-acetylserotonin and melatonin in transgenic rice plants. PMID: 20586889
    7. Identified 17 sequence changes in AANAT gene of patients with major depression. Show evidence of the association of genetic variability in the AANAT gene with susceptibility to major depression. PMID: 20459461
    8. There is a significant increase in AANAT allele positivity at the single nucleotide polymorphism (alanine 129--> threonine) at between patients with DSPS & controls. AA-NAT could be a susceptibility gene for DSPS. PMID: 12736803
    9. Data suggest that the -263G/C single nucleotide polymorphism of arylalkylamine-N-acetyl-transferase (AA-NAT) may be an important determinant of the late/short sleep pattern. PMID: 15332344
    10. Single nucleotide polymorphisms in the AANAT gene identified thus far cannot explain the observed interindividual differences for nocturnal melatonin profiles in the subjects investigated. PMID: 18569588
    11. AANAT polymorphisms were not associated with adolescent idiopathic scoliosis. PMID: 18794762
    12. Observational study of genotype prevalence and gene-disease association. (HuGE Navigator) PMID: 17503170

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    Acetyltransferase family, AANAT subfamily
  • 組織特異性:
    Highly expressed in pineal gland and at lower levels in the retina. Weak expression in several brain regions and in the pituitary gland.
  • 數據庫鏈接:

    HGNC: 19

    OMIM: 600950

    KEGG: hsa:15

    STRING: 9606.ENSP00000250615

    UniGene: Hs.431417



主站蜘蛛池模板: 欧美肥妇bwbwbwbxx| 一区二区三区四区在线 | 中国| 亚洲中文字幕无码久久2020| 日韩欧美tⅴ一中文字暮| 狠狠噜天天噜日日噜视频麻豆| 国产精品成人99一区无码| 中文字幕精品一区二区精品| 久久精品成人免费国产| 67194熟妇人妻欧美日韩| 国产成人精品无码a区在线观看| 国产精品自产拍高潮在线观看 | 黑人玩弄人妻1区二区| 丁香五月开心婷婷激情综合| 人妻熟妇乱又伦精品视频无广告 | 国产欧美久久一区二区| 国精品人妻无码一区二区三区d3| 国产福利日本一区二区三区| 裸体女人高潮毛片| 亚洲午夜无码久久| 精品人妻少妇一区二区三区在线| 丁香五月缴情在线| 国产产品亚洲产品| 国产freexxxx性播放麻豆| 成人亚洲欧美成αⅴ人在线观看| 亚洲乱码卡一卡二卡| 国产精品狼人久久久久影院| av不卡国产在线观看| 欧美最猛黑人xxxxx猛交| 久久精品亚洲日本波多野结衣 | 夜爽8888视频在线观看| 国产av一区二区精品凹凸| 最新国产麻豆aⅴ精品无码| 国产精品51麻豆cm传媒| 亚洲最大的imax影院| 免费乱理伦片在线观看八戒| 国产suv精品一区二区33| 毛片24种姿势无遮无拦| 国产午夜精华无码网站| 18禁午夜宅男成年网站| 国产精品三级在线观看无码| 国产内射999视频一区|