Histone H2B Monoclonal Antibody
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中文名稱(chēng)：組蛋白H2B鼠單克隆抗體
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貨號(hào)：CSB-MA000324
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規(guī)格：￥1090
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圖片：
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Western blot analysis of 1) Hela, 2) 3T3, 3) Raw264.7, 4) Rat Brain, 5) Rat Kidney, diluted at 1:2000.
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其他：
產(chǎn)品詳情
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產(chǎn)品描述：CUSABIO貨號(hào)：CSB-MA000324組蛋白H2B單克隆抗體是專(zhuān)為生命科學(xué)研究設(shè)計(jì)的核心實(shí)驗(yàn)試劑，靶向高度保守的核小體結(jié)構(gòu)蛋白Histone H2B。作為染色質(zhì)組裝的關(guān)鍵組分，H2B通過(guò)與H2A形成異源二聚體參與DNA包裝和表觀(guān)遺傳調(diào)控，在細(xì)胞周期進(jìn)程、DNA修復(fù)及基因表達(dá)中發(fā)揮重要作用。該抗體經(jīng)嚴(yán)格驗(yàn)證適用于人、小鼠、大鼠三大模式生物的實(shí)驗(yàn)體系，在Western Blot實(shí)驗(yàn)中可清晰識(shí)別約14kDa的目標(biāo)條帶，同時(shí)兼容ELISA檢測(cè)平臺(tái)，為研究者提供可靠的蛋白識(shí)別工具。在表觀(guān)遺傳調(diào)控機(jī)制研究、干細(xì)胞分化模型構(gòu)建、腫瘤微環(huán)境分析等前沿領(lǐng)域具有重要應(yīng)用價(jià)值，尤其適用于染色質(zhì)動(dòng)態(tài)變化觀(guān)察、組蛋白修飾互作研究及表觀(guān)遺傳藥物開(kāi)發(fā)等科研場(chǎng)景。其高特異性和批次穩(wěn)定性已通過(guò)多物種組織裂解液測(cè)試驗(yàn)證，是探索基因表達(dá)調(diào)控網(wǎng)絡(luò)和疾病分子機(jī)制的首選抗體試劑。
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Uniprot No.：
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基因名：HIST1H2BB
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別名：HIST1H2BB antibody; H2BFFHistone H2B type 1-B antibody; Histone H2B.1 antibody; Histone H2B.f antibody; H2B/f antibody
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宿主：Mouse
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Synthetic Peptide
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免疫原種屬：H, M, R
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標(biāo)記方式：Non-conjugated
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抗體亞型：IgG
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克隆號(hào)：24D11
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:5000 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
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基因功能參考文獻(xiàn)：
- Functional crosstalk between histone H2B ubiquitylation and H2A modifications and variants has been uncovered. PMID: 29643390
- RNF20 and H2Bub1 promotes chronic colonic inflammation and inflammation-associated colorectal cancer in mice and humans, partly by augmenting NF-kappaB activity and attenuating the antitumoral T cell response. PMID: 26854224
- RNF20-mediated H2B ubiquitination at DSBs plays a critical role in HRR through chromatin remodeling PMID: 21362548
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亞細(xì)胞定位：Nucleus. Chromosome.
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蛋白家族：Histone H2B family
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數(shù)據(jù)庫(kù)鏈接：
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