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  4. DYNC1LI1 Monoclonal Antibody

DYNC1LI1 Monoclonal Antibody

  • 中文名稱：
    DYNC1LI1 Monoclonal Antibody
  • 貨號：
    CSB-MA082736
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of DYNC1LI1 expression in HepG2 cells using DYNC1LI1 antibody. Green, isotype control; red, DYNC1LI1.
    • Immunocytochemical staining of HepG2 cells with DYNC1LI1 antibody. Nuclei were stained blue with DAPI; DYNC1LI1 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
    • Western blotting analysis using DYNC1LI1 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with DYNC1LI1 antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
  • 其他：

產品詳情

  • 產品名稱：
    Mouse anti-Homo sapiens (Human) DYNC1LI1 Monoclonal antibody
  • Uniprot No.：
  • 基因名：
    DYNC1LI1
  • 別名：
    DYNC1LI1; Dynein Cytoplasmic 1 Light Intermediate Chain 1; DNCLI1; Dynein, Cytoplasmic, Light Intermediate Polypeptide 1; Cytoplasmic Dynein 1 Light Intermediate Chain 1; Dynein Light Intermediate Chain 1, Cytosolic 3; Dynein Light Chain A; DLIC-1; DLC-A; LIC1
  • 宿主：
    Mouse
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human DYNC1LI1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    23G6
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2500
    FC 1:100-1:1000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores.
  • 基因功能參考文獻：
    1. conserved mechanism of effector interaction with dynein-dynactin necessary for processive motility PMID: 29515126
    2. the DYNC1I1 deficiency, a neuron-specific dynein intermediate chain, causes neuronal atrophy in primary hippocampal neurons. PMID: 27510948
    3. This work reveals the structural details of Hook3's interaction with dynein and offers insight into how cargo adaptors form processive dynein-dynactin motor complexes. PMID: 27482052
    4. although dynein lacking light intermediate chains (LICs) drives microtubule gliding at normal rates, the LICs are required for the formation and maintenance of a bipolar spindle. PMID: 25422374
    5. using a variety of complementary approaches, our results indicate a novel specific role for the LICs in dynein recruitment to components of the late endocytic pathway. PMID: 21169557
    6. Rab11a, FIP3 and DLIC-1 form a ternary complex and DLIC-1 colocalises with endogenous FIP3 and Rab11a in A431 cells. PMID: 20026645
    7. Dynein light intermediate chain 1 is required for progress through the spindle assembly checkpoint PMID: 19229290

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  • 亞細胞定位：
    Cytoplasm. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole.
  • 蛋白家族：
    Dynein light intermediate chain family
  • 數據庫鏈接：

    HGNC: 18745

    OMIM: 615890

    KEGG: hsa:51143

    STRING: 9606.ENSP00000273130

    UniGene: Hs.529495



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