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  4. CDCA8 Monoclonal Antibody

CDCA8 Monoclonal Antibody

  • 中文名稱：
    CDCA8 Monoclonal Antibody
  • 貨號：
    CSB-MA948730
  • 規格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of Cell division cycle associated 8 expression in HAP-1 cells using Cell division cycle associated 8 antibody. Green, isotype control; red, Cell division cycle associated 8.
    • Immunocytochemical staining of HAP-1 cells with Cell division cycle associated 8 antibody. Nuclei were stained blue with DAPI; Cell division cycle associated 8 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
    • Western blotting analysis using cell division cycle associated 8 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with cell division cycle associated 8 antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
  • 其他：

產品詳情

  • 產品名稱：
    Mouse anti-Homo sapiens (Human) CDCA8 Monoclonal antibody
  • Uniprot No.：
  • 基因名：
    CDCA8
  • 別名：
    CDCA8; Cell Division Cycle Associated 8; Borealin; MESRGP; DasraB; BOR; Pluripotent Embryonic Stem Cell-Related Gene 3 Protein; Cell Division Cycle-Associated Protein 8; FLJ12042; HDasra-B; Dasra-B; Dasra B; PESCRG3
  • 宿主：
    Mouse
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human CDCA8 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    16F2
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2500
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment.
  • 基因功能參考文獻：
    1. Results show that CDCA8 is overexpressed in bladder cancer (BC) and its high levels are correlated with poor clinicopathological features of BC patients. Therefore, CDCA8 may act as a novel prognostic marker in the diagnosis of patients with BC. PMID: 30142792
    2. These results were well correlated with the same gene expression pattern analysed in the thyroid tissue of the patient with BOREALIN-p.R114W. These studies open new avenues in the genetics of TD in humans. PMID: 28025328
    3. Borealin dimerization mediates chromosomal passenger complex checkpoint function by enhancing localization to centromeres and kinetochores. PMID: 25854549
    4. enhanced CDCA8 promoter activities by NF-Y overexpression and reduced CDCA8 transcription by NF-Y knockdown further verified that NF-Y is a positive regulator of CDCA8 transcription. PMID: 26170459
    5. In colorectal cancer patients, Borealin expression was positively correlated with age, lymph node metastasis and neoplasm staging. PMID: 25260804
    6. These findings reveal a previously unrecognized but direct link between HP1 and CPC localization in the centromere and illustrate the critical role of borealin-HP1 interaction in orchestrating an accurate cell division. PMID: 24917673
    7. Borealin interacts directly with the Snf7 components of ESCRT-III in human cells.the Borealin central region encompassing residues 110-207 was both necessary & sufficient to bind to CHMP4C. PMID: 22724069
    8. MLL5 functionally interacts with Borealin, facilitates the expression of chromosomal passenger complex, and hence contributes to mitotic fidelity and genomic integrity. PMID: 22797924
    9. important role for phosphorylation of Borealin at S219 in the proper progression through mitosis PMID: 20803554
    10. Data show that INCENP has an important role in stabilizing the chromosomal passenger complex, and that Borealin acts to promote binding of Survivin to INCENP. PMID: 16239925
    11. Cell cycle-regulated chromosomal passenger protein whose aberrant expression and nuclear accumulation are linked to poor prognosis for gastric cancer. PMID: 16427043
    12. A functional module within the chromosomal passenger complex involving the inner centromere protein INCENP, Survivin, and Borealin. PMID: 16571674
    13. Borealin is phosphorylated during mitosis. Neither residue S165, T106 nor phosphorylation of borealin by Aurora B Kinase is required to generate the mitotic, shifted form of Borealin. PMID: 17241471
    14. Suppression of CDCA8 expression with small interfering RNA against CDCA8 significantly suppressed the growth of lung cancer cells. PMID: 17483322
    15. It is recorded that borealin is a cell cycle regulator, down-regulated in response to p53/Rb-signaling, and up-regulated in many types of cancerous tissues. PMID: 17716930
    16. mitotic regulator Survivin binds as a monomer to its functional interactor Borealin PMID: 17881355
    17. Borealin and INCENP associate with the helical domain of Survivin to form a tight three-helical bundle. PMID: 17956729
    18. Borealin plays a crucial role in the early mouse embryonic development PMID: 18311593
    19. Data describe a mitotic SUMO2/3 conjugation-deconjugation cycle of Borealin and further assign a regulatory function of RanBP2 and SENP3 in the mitotic SUMO pathway. PMID: 18946085
    20. found that substitutions at Borealin T230, recently identified as an Mps1 phosphorylation site, can modulate the dimerization state of Borealin PMID: 19530738

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  • 亞細胞定位：
    Nucleus, nucleolus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere.
  • 蛋白家族：
    Borealin family
  • 數據庫鏈接：

    HGNC: 14629

    OMIM: 609977

    KEGG: hsa:55143

    STRING: 9606.ENSP00000316121

    UniGene: Hs.524571



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