在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CDCA8 Antibody

  • 中文名稱:
    CDCA8兔多克隆抗體
  • 貨號:
    CSB-PA700653ESR2HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA700653ESR2HU at dilution of 1: 100
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) CDCA8 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    CDCA8
  • 別名:
    BOR antibody; BOREA_HUMAN antibody; Borealin antibody; CDCA8 antibody; Cell division cycle associated 8 antibody; cell division cycle associated protein 8 antibody; Cell division cycle-associated protein 8 antibody; Dasra B antibody; Dasra-B antibody; DasraB antibody; FLJ10468 antibody; FLJ12042 antibody; hDasra B antibody; hDasra-B antibody; MESRGP antibody; OTTHUMP00000004514 antibody; pluripotent embryonic stem cell related gene 3 protein antibody; Pluripotent embryonic stem cell-related gene 3 protein antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Borealin protein (1-280AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment.
  • 基因功能參考文獻:
    1. Results show that CDCA8 is overexpressed in bladder cancer (BC) and its high levels are correlated with poor clinicopathological features of BC patients. Therefore, CDCA8 may act as a novel prognostic marker in the diagnosis of patients with BC. PMID: 30142792
    2. These results were well correlated with the same gene expression pattern analysed in the thyroid tissue of the patient with BOREALIN-p.R114W. These studies open new avenues in the genetics of TD in humans. PMID: 28025328
    3. Borealin dimerization mediates chromosomal passenger complex checkpoint function by enhancing localization to centromeres and kinetochores. PMID: 25854549
    4. enhanced CDCA8 promoter activities by NF-Y overexpression and reduced CDCA8 transcription by NF-Y knockdown further verified that NF-Y is a positive regulator of CDCA8 transcription. PMID: 26170459
    5. In colorectal cancer patients, Borealin expression was positively correlated with age, lymph node metastasis and neoplasm staging. PMID: 25260804
    6. These findings reveal a previously unrecognized but direct link between HP1 and CPC localization in the centromere and illustrate the critical role of borealin-HP1 interaction in orchestrating an accurate cell division. PMID: 24917673
    7. Borealin interacts directly with the Snf7 components of ESCRT-III in human cells.the Borealin central region encompassing residues 110-207 was both necessary & sufficient to bind to CHMP4C. PMID: 22724069
    8. MLL5 functionally interacts with Borealin, facilitates the expression of chromosomal passenger complex, and hence contributes to mitotic fidelity and genomic integrity. PMID: 22797924
    9. important role for phosphorylation of Borealin at S219 in the proper progression through mitosis PMID: 20803554
    10. Data show that INCENP has an important role in stabilizing the chromosomal passenger complex, and that Borealin acts to promote binding of Survivin to INCENP. PMID: 16239925
    11. Cell cycle-regulated chromosomal passenger protein whose aberrant expression and nuclear accumulation are linked to poor prognosis for gastric cancer. PMID: 16427043
    12. A functional module within the chromosomal passenger complex involving the inner centromere protein INCENP, Survivin, and Borealin. PMID: 16571674
    13. Borealin is phosphorylated during mitosis. Neither residue S165, T106 nor phosphorylation of borealin by Aurora B Kinase is required to generate the mitotic, shifted form of Borealin. PMID: 17241471
    14. Suppression of CDCA8 expression with small interfering RNA against CDCA8 significantly suppressed the growth of lung cancer cells. PMID: 17483322
    15. It is recorded that borealin is a cell cycle regulator, down-regulated in response to p53/Rb-signaling, and up-regulated in many types of cancerous tissues. PMID: 17716930
    16. mitotic regulator Survivin binds as a monomer to its functional interactor Borealin PMID: 17881355
    17. Borealin and INCENP associate with the helical domain of Survivin to form a tight three-helical bundle. PMID: 17956729
    18. Borealin plays a crucial role in the early mouse embryonic development PMID: 18311593
    19. Data describe a mitotic SUMO2/3 conjugation-deconjugation cycle of Borealin and further assign a regulatory function of RanBP2 and SENP3 in the mitotic SUMO pathway. PMID: 18946085
    20. found that substitutions at Borealin T230, recently identified as an Mps1 phosphorylation site, can modulate the dimerization state of Borealin PMID: 19530738

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus, nucleolus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere.
  • 蛋白家族:
    Borealin family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 14629

    OMIM: 609977

    KEGG: hsa:55143

    STRING: 9606.ENSP00000316121

    UniGene: Hs.524571



主站蜘蛛池模板: 久久久久亚洲精品天堂| 亚洲国产一区二区三区波多野结衣 | 50岁退休熟女露脸高潮 | 无遮挡男女激烈动态图| 女人国产香蕉久久精品| 熟妇人妻系列aⅴ无码专区友真希 内射囯产旡码丰满少妇 | av色综合久久天堂av色综合| 18禁裸体动漫美女无遮挡网站 | 无码av免费永久免费永久专区 | 亚洲色婷婷一区二区三区| 成人麻豆日韩在无码视频| 免费网站看v片在线18禁无码| 欧美乱码卡一卡二卡三新区| 国产成人精品亚洲日本在线观看| 亚洲v国产v欧美v久久久久久| 午夜福制92视频| 亚洲成a人片在线观看你懂的| 无码专区人妻系列日韩精品少妇| 国产毛片精品av一区二区| 色哟哟免费视频播放网站| 精品人妻av区波多野结衣| 四虎国产精品永久在线| 国产午夜亚洲精品久久| 麻豆成人av不卡一二三区| 成 人 免费观看网站| 与子敌伦刺激对白播放的优点| 中文成人无码精品久久久动漫| 中文字幕日韩一区二区不卡| 97se亚洲国产综合在线 | 少妇人妻挤奶水中文视频毛片| 亚洲精品毛片一区二区三区| 兔费看少妇性l交大片免费| 日本人又黄又爽又色的视频| 2019一級特黃色毛片免費看| 亚洲精品国产精品国自产观看| 亚洲国产av玩弄放荡人妇| 色综合亚洲一区二区小说性色aⅴ| 成年男女免费视频网站| 日本乱偷互换人妻中文字幕| 四虎精品国产永久在线观看| 色妞www精品视频|