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  4. AGBL2 Monoclonal Antibody

AGBL2 Monoclonal Antibody

  • 中文名稱：
    AGBL2鼠單克隆抗體
  • 貨號：
    CSB-MA732978A0m
  • 規格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate, MCF-7 whole cell lysate, PC-3 whole cell lysate
      All lanes: AGBL2 antibody at 1:1000
      Secondary
      Goat polyclonal to mouse IgG at 1/50000 dilution
      Predicted band size: 32 KDa
      Observed band size: 32, 49, 104 KDa
      Exposure time：5min
  • 其他：

產品詳情

  • 產品描述：
    CUSABIO貨號：CSB-MA732978A0m AGBL2單克隆抗體是針對人源AGBL2（ATP/GTP結合蛋白樣2）靶點研發的高特異性科研試劑，該蛋白作為胞內羧肽酶家族成員，在蛋白質翻譯后修飾及細胞信號調控中發揮重要作用，其異常表達與多種生理病理過程相關。本產品經Western Blot（WB）和ELISA雙平臺驗證，采用雜交瘤技術制備，具有明確的IgG亞型鑒定及嚴格的親和純化工藝，確保批次間高一致性。在腫瘤微環境研究、神經退行性疾病機制探索等科研場景中，該抗體可精準識別內源性AGBL2蛋白，助力研究者解析其在不同細胞模型或組織樣本中的表達分布規律及功能調控網絡。作為經多實驗體系驗證的可靠工具，本品適用于蛋白互作研究、信號通路圖譜構建及疾病相關生物標志物篩選等基礎研究領域，為精準醫學研究提供關鍵技術支持。
  • 產品名稱：
    Mouse anti-Homo sapiens (Human) AGBL2 Monoclonal Antibody antibody
  • Uniprot No.：
  • 基因名：
    AGBL2
  • 別名：
    AGBL 2 antibody; AGBL2 antibody; ATP/GTP binding protein like 2 antibody; ATP/GTP-binding protein-like 2 antibody; Carboxypeptidase 2 cytosolic antibody; CBPC2_HUMAN antibody; CCP2 antibody; Cytosolic carboxypeptidase 2 antibody; FLJ23598 antibody
  • 宿主：
    Mouse
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Cytosolic carboxypeptidase 2 protein (10-270AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal Antibody
  • 抗體亞型：
    IgG2b
  • 純化方式：
    Affinity purification
  • 克隆號：
    1F3C12
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin protein. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of non-tubulin proteins such as MYLK.
  • 基因功能參考文獻：
    1. Findings suggest that ATP/GTP binding protein like 2 (AGBL2) plays a critical oncogenic role in the pathogenesis of hepatocellular carcinoma (HCC) through modulation on immunity-related GTPase family, M protein (IRGM)-regulated autophagy and aurora kinase A (Aurora A) activity. PMID: 29126912
    2. Suggest role for AGBL2 in cell proliferation and chemotherapy resistance in gastric cancer. PMID: 25916089
    3. High AGBL2 expression is associated with breast cancer. PMID: 24884516
    4. RARRES1, its interacting partners AGBL2, Eg5/KIF11, another EEY-bearing protein (EB1), and the microtubule tyrosination cycle are important in tumorigenesis. PMID: 21303978
  • 亞細胞定位：
    Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body.
  • 蛋白家族：
    Peptidase M14 family
  • 數據庫鏈接：

    HGNC: 26296

    OMIM: 617345

    KEGG: hsa:79841

    STRING: 9606.ENSP00000298861

    UniGene: Hs.147377



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