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  4. Rat selenoprotein P, plasma, 1 (SEPP1)ELISA kit

Rat selenoprotein P, plasma, 1 (SEPP1)ELISA kit

  • 中文名稱：
    大鼠硒蛋白P(SEPP1)酶聯免疫試劑盒
  • 貨號：
    CSB-E17683r
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    大鼠硒蛋白P(SEPP1)酶聯免疫試劑盒（CSB-E17683r）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的SEPP1含量。SEPP1即硒蛋白P，它是含硒量最高的硒蛋白，在維持體內硒穩態等方面發揮重要作用。研究發現它參與抗氧化、抗炎等機制，與動脈粥樣硬化、神經系統疾病等多種病理過程相關，是藥物研發等領域頗具潛力的靶點。試劑盒檢測范圍為78 pg/mL-5000 pg/mL，本產品適用于科研領域對硒蛋白代謝調控機制的研究。適配多種生物樣本類型，尤其適用于探究肝臟疾病模型、營養性硒缺乏或氧化應激相關實驗中SEPP1的動態變化，為研究硒元素代謝通路、抗氧化系統功能以及相關疾病分子機制提供可靠的檢測工具，廣泛應用于基礎醫學、營養學及分子生物學領域的實驗需求。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    Selenop ELISA Kit; Selp ELISA Kit; Sepp1 ELISA Kit; Selenoprotein P ELISA Kit; SeP) [Cleaved into: Selenoprotein Se-P10; Selenoprotein Se-P6; Selenoprotein Se-P2; Selenoprotein Se-P1] ELISA Kit
  • 縮寫：
    SEPP1
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    78 pg/mL-5000 pg/mL
  • 靈敏度：
    19.5 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Others
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%        
    Three samples of known concentration were tested twenty times on one plate to assess.    
    Inter-assay Precision (Precision between assays): CV%<10%        
    Three samples of known concentration were tested in twenty assays to assess.      
                   
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of rat SEPP1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.  
    　 Sample Serum(n=4)    
    1:1000 Average % 92    
    Range % 88-96    
    1:2000 Average % 105    
    Range % 100-110    
    1:4000 Average % 96    
    Range % 92-100    
    1:8000 Average % 89    
    Range % 84-93    
  • 回收率：
    The recovery of rat SEPP1 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.  
     
    Sample Type Average % Recovery Range    
    Serum (n=5) 98 94-102    
    EDTA plasma (n=4) 85 80-90    
                   
                   
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.  
     
    pg/ml OD1 OD2 Average Corrected    
    5000 2.522 2.496 2.509 2.354    
    2500 1.949 2.023 1.986 1.831    
    1250 1.613 1.584 1.599 1.444    
    625 1.186 1.135 1.161 1.006    
    312 0.754 0.721 0.738 0.583    
    156 0.448 0.460 0.454 0.299    
    78 0.315 0.297 0.306 0.151    
    0 0.151 0.158 0.155 　    
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis.
  • 基因功能參考文獻：
    1. A chromatin immunoprecipitation (ChIP) assay revealed that EPA decreases binding of SREBP-1c to the SELENOP promoter. Knockdown of Srebf1 resulted in a significant down-regulation of Selenop expression. PMID: 28465347
    2. Data indicate that Selenoprotein P SEPP1 processivity is intrinsic, but efficiency is governed by selenium levels. PMID: 25063811
    3. metformin decreases binding of FoxO3a, a direct target of AMPK, to the SEPP1 promoter. PMID: 24257750
    4. Sepp1 secreted from epithelial cells may support the intestinal immune system by providing immune cells (including plasma cells) with selenium PMID: 24157689
    5. apoER2-mediated uptake of long isoform Sepp1 is responsible for selenium distribution to tissues throughout the body. PMID: 22761431
    6. investigation of Sepp1 expression in adipocytes during adipogenesis and oxidative stress in models of obesity and insulin resistance PMID: 20959537
    7. tear SeP is a key molecule to protect the ocular surface cells against environmental oxidative stress PMID: 20360971
    8. mass spectrometric characterization of full-length protein and three isoforms shortened at the C terminus PMID: 11821412
    9. selenenylsulfide linkages Sec304-Cys314 and Cys306-Sec316 were present; selenoprotein P contains these two selenenylsulfide bonds PMID: 15712351
    10. Sertoli cell ApoER2 is a Sepp1 receptor and a component of the selenium delivery pathway to spermatogenic cells PMID: 17314095
    11. In conclusion, the selenoprotein P promoter is a target of the Akt/FoxO signal transduction cascade and SeP expression is regulated at the level of transcription by the forkhead box protein FoxO1a in human and rat hepatoma cells. PMID: 17986386

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Selenoprotein P family
  • 組織特異性：
    Widely expressed, mainly by the liver. Secreted in plasma.
  • 數據庫鏈接：

    KEGG: rno:29360

    UniGene: Rn.1451



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