在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 試劑盒
  3. 酶聯免疫試劑盒
  4. Rat interferon-inducible protein 10,IP-10 ELISA Kit

Rat interferon-inducible protein 10,IP-10 ELISA Kit

  • 中文名稱：
    大鼠干擾素誘導蛋白10(IP-10/CXCL10)酶聯免疫試劑盒
  • 貨號：
    CSB-E08182r
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    大鼠干擾素誘導蛋白10(IP-10/CXCL10)酶聯免疫試劑盒（CSB-E08182r）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的CXCL10含量。CXCL10是一個重要的靶點。它屬于趨化因子家族，在免疫調節等生理過程中發揮關鍵作用。其背景涉及多種疾病，如炎癥、腫瘤等。研究機制方面，主要聚焦于它與受體結合，介導細胞趨化、激活免疫細胞等，以揭示其在疾病發生發展中的具體作用。試劑盒檢測范圍為781.25 pg/mL-50000 pg/mL，適用于基礎科研中評估炎癥模型（如肝炎、腦炎或關節炎）、免疫調節機制研究、腫瘤相關免疫微環境分析，以及藥物干預或基因修飾對IP-10/CXCL10表達調控的實驗需求。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    Cxcl10 ELISA kit; Inp10 ELISA kit; Mob1 ELISA kit; Scyb10C-X-C motif chemokine 10 ELISA kit; 10 kDa interferon gamma-induced protein ELISA kit; Gamma-IP10 ELISA kit; IP-10 ELISA kit; Interferon-inducible protein 10 ELISA kit; Protein Mob-1 ELISA kit; Small-inducible cytokine B10 ELISA kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    781.25 pg/mL-50000 pg/mL
  • 靈敏度：
    195 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of rat IP-10 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:1Average %88
    Range %84-92
    1:2Average %94
    Range %90-98
    1:4Average %99
    Range %95-104
    1:8Average %102
    Range %96-108
  • 回收率：
    The recovery of rat IP-10 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 8993-96
    EDTA plasma (n=4)10095-105
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    500002.556 2.581 2.569 2.437
    250001.748 1.769 1.759 1.627
    125001.002 1.085 1.044 0.912
    62500.663 0.699 0.681 0.549
    31250.396 0.387 0.392 0.260
    1562.50.284 0.271 0.278 0.146
    781.250.219 0.230 0.225 0.093
    00.131 0.133 0.132 　
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects. Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites. Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation. Activation of the CXCL10/CXCR3 axis plays also an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization.
  • 基因功能參考文獻：
    1. These observations provide evidence for IP-10 in a regulatory role in cold ischemia-elicited acute allograft rejection and in PRINS lncRNA expression PMID: 29880386
    2. CXCL10 is a circulating inflammatory marker elevated in advanced heart failure. PMID: 27271043
    3. data support our hypothesis that increased circulating IFN-gamma and glomerular TNF-alpha induce synergistically the production and secretion of CXCL10 by podocytes, attracting activated macrophages into kidney tissue. PMID: 25561167
    4. CXCL10 is a regulator for an increase of opioid-containing macrophages and antinociceptive mediator in inflammatory pain and as a key chemokine regulated by electroacupuncture PMID: 24732949
    5. CXCL10 may be a necessary algogenic molecule, especially in the development of Cancer-induced bone pain PMID: 24337539
    6. CXCL10 is involved in astrocyte migration in amyloid-beta-stimulated hippocampal astrocytes. PMID: 23270423
    7. CXCL10 is a potential candidate for the reduction in myelination in cultures on TnC-astrocytes PMID: 21917786
    8. CXCL10 and CCL5 but not CXCL11 are involved in the pathogenesis of multiple sclerosis. PMID: 20720435
    9. upregulated in endometriosis tissues PMID: 20452033
    10. interferon-inducible protein 10 (IP-10) as ethanol-responsive gene in the fetal rat brain PMID: 12354640
    11. Antibodies to this chemokine increase IFNgamma in BALF of F344 rats following Sendai virus infection. PMID: 12581489
    12. CXCL10-induced elevations in intracellular Ca2+ are associated with an increase in neuronal firing and an alteration in the relationship between the evoked Ca2+ signal and activity of hippocampal neurons. PMID: 15465598
    13. IP-10/CXCR3 signaling is associated with the pathogenesis of experimental autoimmune myasthenia gravis in rats. PMID: 15843529
    14. Our study demonstrates a role of IP-10/CXCL10 on T cell recruitment in a rat model of renal endothelial microvascular injury PMID: 16382019
    15. this study shows that IP-10 contributes to the regulation of the expression of SD (slit-diaphram) components not only in the physiologic state but also in pathologic states. PMID: 16382022
    16. Inhibition of CXCR3/IP-10 signaling can be considered as a potential treatment modality for myasthenia gravis. PMID: 19232748

    顯示更多

    收起更多

  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine alpha (chemokine CxC) family
  • 組織特異性：
    In the central nervous system, CXCL10 is predominantly localized to activated neurons. Expressed in both microglia and astrocytes.
  • 數據庫鏈接：


主站蜘蛛池模板： 国产农村妇女毛片精品久久| 中文人妻av大区中文不卡 | 蜜柚av久久久久久久| 久久久久人妻一区精品色| 国产精品99久久免费黑人人妻| 亚洲成在人线免费观看| 色婷婷狠狠97成为人免费| 亚洲熟妇无码av不卡在线| 亚洲精品无码一区二区| 岛国片人妻三上悠亚| 精品国产不卡在线观看免费| 国产播放隔着超薄丝袜进入| 精品久久人人爽天天玩人人妻 | 久久综合给合综合久久| 国产又色又爽无遮挡免费| 国产无遮挡乱子伦免费精品| 好疼太大了太粗太长了视频| 女人被狂躁c到高潮喷水一区二区| 欧美孕妇乳喷奶水在线观看| av无码中文字幕不卡一区二区三区| 伊人久久大香线蕉综合中文字幕| 人妻无码久久久久久久久久久| 欧亚精品一区三区免费| 国产理论剧情大片在线播放| 暖暖视频日本| 中文无码一区二区不卡av| 欧美激情猛片xxxⅹ大3| 亚洲国产香蕉碰碰人人| 久人人爽人人爽人人片av| 久久男人av资源站| 亚洲 卡通 欧美 制服 中文| 永久免费无码网站在线观看| 丰满诱人的人妻3| 吃奶摸下高潮60分钟免费视频| 美女网站免费福利视频| 999国内精品永久免费视频 | 色综合久久久久综合体桃花网| 97人妻免费公开在线视频| 少妇人妻偷人精品无码视频新浪| 中国少妇无码专区| av高清无码 在线播放|