在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Rat C-X-C motif chemokine 10 protein (Cxcl10)

In Stock
  • 中文名稱:
    Recombinant Rat C-X-C motif chemokine 10 protein(Cxcl10) (Active)
  • 貨號:
    CSB-AP001451RA
  • 規格:
    ¥1020
  • 圖片:
  • 其他:

產品詳情

  • 純度:
    >95% as determined by SDS-PAGE.
  • 內毒素:
    Less than 1.0 EU/μg as determined by LAL method.
  • 生物活性:
    Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human CXCR3 transfected HEK293 cells is in a concentration range of 10-50 ng/ml.
  • 基因名:
  • Uniprot No.:
  • 別名:
    Cxcl10; Inp10; Mob1; Scyb10C-X-C motif chemokine 10; 10 kDa interferon gamma-induced protein; Gamma-IP10; IP-10; Interferon-inducible protein 10; Protein Mob-1; Small-inducible cytokine B10
  • 種屬:
    Rattus norvegicus (Rat)
  • 蛋白長度:
    Full Length of Mature Protein
  • 來源:
    E.Coli
  • 分子量:
    8.7 kDa
  • 表達區域:
    22-98aa
  • 氨基酸序列
    IPLARTVRCT CIDFHEQPLR PRAIGKLEII PASLSCPHVE IIATMKKNNE KRCLNPESEA IKSLLKAVSQ RRSKRAP
  • 蛋白標簽:
    Tag-Free
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    0.2 μm filtered PBS, pH 7.4 ,lyophilized
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    5-10 business days
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects. Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites. Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation. Activation of the CXCL10/CXCR3 axis plays also an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization.
  • 基因功能參考文獻:
    1. These observations provide evidence for IP-10 in a regulatory role in cold ischemia-elicited acute allograft rejection and in PRINS lncRNA expression PMID: 29880386
    2. CXCL10 is a circulating inflammatory marker elevated in advanced heart failure. PMID: 27271043
    3. data support our hypothesis that increased circulating IFN-gamma and glomerular TNF-alpha induce synergistically the production and secretion of CXCL10 by podocytes, attracting activated macrophages into kidney tissue. PMID: 25561167
    4. CXCL10 is a regulator for an increase of opioid-containing macrophages and antinociceptive mediator in inflammatory pain and as a key chemokine regulated by electroacupuncture PMID: 24732949
    5. CXCL10 may be a necessary algogenic molecule, especially in the development of Cancer-induced bone pain PMID: 24337539
    6. CXCL10 is involved in astrocyte migration in amyloid-beta-stimulated hippocampal astrocytes. PMID: 23270423
    7. CXCL10 is a potential candidate for the reduction in myelination in cultures on TnC-astrocytes PMID: 21917786
    8. CXCL10 and CCL5 but not CXCL11 are involved in the pathogenesis of multiple sclerosis. PMID: 20720435
    9. upregulated in endometriosis tissues PMID: 20452033
    10. interferon-inducible protein 10 (IP-10) as ethanol-responsive gene in the fetal rat brain PMID: 12354640
    11. Antibodies to this chemokine increase IFNgamma in BALF of F344 rats following Sendai virus infection. PMID: 12581489
    12. CXCL10-induced elevations in intracellular Ca2+ are associated with an increase in neuronal firing and an alteration in the relationship between the evoked Ca2+ signal and activity of hippocampal neurons. PMID: 15465598
    13. IP-10/CXCR3 signaling is associated with the pathogenesis of experimental autoimmune myasthenia gravis in rats. PMID: 15843529
    14. Our study demonstrates a role of IP-10/CXCL10 on T cell recruitment in a rat model of renal endothelial microvascular injury PMID: 16382019
    15. this study shows that IP-10 contributes to the regulation of the expression of SD (slit-diaphram) components not only in the physiologic state but also in pathologic states. PMID: 16382022
    16. Inhibition of CXCR3/IP-10 signaling can be considered as a potential treatment modality for myasthenia gravis. PMID: 19232748

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    Intercrine alpha (chemokine CxC) family
  • 組織特異性:
    In the central nervous system, CXCL10 is predominantly localized to activated neurons. Expressed in both microglia and astrocytes.
  • 數據庫鏈接:


主站蜘蛛池模板: 久久久久女教师免费一区| 亚洲麻豆av成本人无码网站| 韩国无码av片在线观看网站| 亚洲va韩国va欧美va| 国产成人精品无码免费看夜聊软件| 国产精品乱码一区二区三 | 久久综合久久自在自线精品自| a在线观看免费网站大全| 国内最真实的xxxx人伦| 欧美黑人粗大xxxxbbbb| 极品粉嫩福利午夜在线播放| 国产成年女人毛片80s网站 | 日本中文一区二区三区亚洲| 熟女人妻aⅴ一区二区三区60路| 人妻丰满熟妇av无码区hd| 国产丝袜在线精品丝袜| 97久久超碰国产精品旧版麻豆| 国产精品久久久久aaaa| 欧美成人午夜免费全部完| 日韩精品无码专区免费视频| 午夜人成免费视频| 日日碰狠狠添天天爽无码| 日韩日韩日韩日韩日韩| 无码国产成人午夜电影观看| 亚洲熟妇丰满xxxxx| 东京热无码av一区二区| 水蜜桃av无码| 粗大的内捧猛烈进出少妇视频| 亚洲欧美中文字幕高清在线| 成熟女人牲交片免费观看视频| 欧美午夜精品一区二区三区电影| 成人午夜高潮刺激免费视频| 强奷妇系列中文字幕| 成人欧美一区二区三区的电影| 夜色福利院在线观看免费| 国产成人av性色在线影院色戒| 亚洲五月天综合| 亚洲中文无码a∨在线观看| 99热这里只有精品国产免费免费| 女人被狂躁的高潮免费视频| 欧美大肥婆大肥bbbbb|