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  4. Rat Urokinase-type Plasminogen Activator Receptor,PLAUR/uPAR ELISA kit

Rat Urokinase-type Plasminogen Activator Receptor,PLAUR/uPAR ELISA kit

  • 中文名稱：
    大鼠尿激酶型纖溶酶原激活物受體(PLAUR/uPAR)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-E07366r
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3900/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    大鼠尿激酶型纖溶酶原激活物受體(PLAUR/uPAR)酶聯(lián)免疫試劑盒（CSB-E07366r）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的PLAUR含量。PLAUR即尿激酶型纖溶酶原激活物受體，在細(xì)胞表面參與調(diào)節(jié)纖溶、細(xì)胞遷移等過(guò)程。其背景上和多種生理病理活動(dòng)相關(guān)，尤其是腫瘤進(jìn)展。研究機(jī)制主要是激活纖溶酶原，促進(jìn)細(xì)胞外基質(zhì)降解，還能與多種信號(hào)通路相互作用，影響細(xì)胞增殖、侵襲等。試劑盒檢測(cè)范圍為0.156 ng/mL-10 ng/mL，適用于探索PLAUR/uPAR在疾病模型中的表達(dá)調(diào)控機(jī)制、生物標(biāo)志物篩選或藥理學(xué)研究中的靶點(diǎn)驗(yàn)證。在腫瘤侵襲轉(zhuǎn)移、炎癥反應(yīng)及纖維化疾病研究中具有重要價(jià)值。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書(shū)。
  • 別名：
    PlaurUrokinase plasminogen activator surface receptor ELISA kit; U-PAR ELISA kit; uPAR ELISA kit; CD antigen CD87 ELISA kit
  • 縮寫(xiě)：
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    0.156 ng/mL-10 ng/mL
  • 靈敏度：
    0.039 ng/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Cancer
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of rat PLAUR/uPAR in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 88
    Range % 84-92
    1:2 Average % 103
    Range % 98-106
    1:4 Average % 95
    Range % 88-99
    1:8 Average % 92
    Range % 87-96
  • 回收率：
    The recovery of rat PLAUR/uPAR spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 92 83-96
    EDTA plasma (n=4) 104 96-108
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average Corrected
    10 2.113 2.273 2.193 2.072
    5 1.643 1.732 1.688 1.567
    2.5 1.072 1.119 1.096 0.975
    1.25 0.682 0.691 0.687 0.566
    0.625 0.404 0.418 0.411 0.290
    0.312 0.276 0.289 0.283 0.162
    0.156 0.206 0.203 0.205 0.084
    0 0.120 0.121 0.121 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA.
  • 基因功能參考文獻(xiàn)：
    1. Increased postmortem PLAUR expression could serve as a biomarker to aid diagnosis of early myocardial infarction. PMID: 24935436
    2. Rapamycin could promote podocyte migration through the up-regulation of uPAR leading to proteinuria. PMID: 24815166
    3. uPA, uPAR, MMP-2 and MMP-9 play an important role in GBM growth. Blockade of uPA and interruption of the proteolytic cascade could become a useful tool in the therapy of GBM PMID: 22773570
    4. uPAR associates with activating enhancer-binding protein 2alpha (AP2a) and mediates beta-catenin gene transcription. PMID: 22511755
    5. study examines the expression and function of uPAR in developing rat ventral prostates PMID: 11798065
    6. Expression pattern of the urokinase-plasminogen activator system in rat DS-sarcoma: role of oxygenation status and tumour size PMID: 11953898
    7. Decreased expression of intercellular adhesion molecule-1 (ICAM-1) is associated with tumor cell spreading in vivo. PMID: 12198772
    8. demonstrated focused activation of proteolytic enzymatic activity in several cell types and showed that the uPA/uPAR system is an important contributor to focal pericellular proteolysis PMID: 15042374
    9. Altered expression of uPAR in diabetic nephropathy was associated with mesangial expansion. PMID: 15322501
    10. Domain 2 of the urokinase receptor plays a pivotal role in the regulation of uPAR-integrin alphavbeta3 interactions PMID: 15863511
    11. The members of caspases, MEK1/2, PKC, and NF-kappaB are involved in TRAIL-induced expression of uPA, IL-8, MMP-7 and MMP-9. PMID: 18397859
    12. In animals undergoing SE, uPAR expression increased dramatically, peaking at 1 and 4 days after SE. Increased uPAR expression during post-injury phase supports its contribution to tissue remodeling in the brain. PMID: 19527776

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  • 亞細(xì)胞定位：
    [Isoform 1]: Cell membrane; Lipid-anchor, GPI-anchor.; [Isoform 2]: Secreted.
  • 數(shù)據(jù)庫(kù)鏈接：


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