在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 試劑盒
  3. 酶聯免疫試劑盒
  4. Mouse Pulmonary Surfactant-associated protein B (SP-B) ELISA kit

Mouse Pulmonary Surfactant-associated protein B (SP-B) ELISA kit

  • 中文名稱：
    小鼠肺表面活性物質相關蛋白B(SP-B)酶聯免疫試劑盒
  • 貨號：
    CSB-E12638m
  • 規格：
    96T/48T
  • 價格：
    ￥3200/￥2500
  • 促銷：
  • 其他：

產品詳情

  • 產品描述：
    小鼠肺表面活性物質相關蛋白B(SP-B)酶聯免疫試劑盒（CSB-E12638m）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的SFTPB含量。小鼠肺表面活性物質相關蛋白B（SP-B）是肺泡表面活性物質的重要組成部分，對降低肺泡表面張力、維持呼吸功能至關重要。研究顯示，SP-B的表達與肺損傷、肺部疾病的發生發展密切相關，其基因多態性可能影響肺部疾病的易感性和臨床預后。通過構建SP-B轉基因小鼠模型，有助于深入探究SP-B在肺部疾病中的作用機制。試劑盒檢測范圍為0.45 ng/mL-30 ng/mL，本產品適用于基礎科研中探究肺部生理病理機制，例如構建急性肺損傷、肺纖維化或新生兒呼吸窘迫綜合征等動物模型時，可通過檢測SP - B的動態變化評估肺功能狀態。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    Sftpb ELISA Kit; Sftp3 ELISA Kit; Pulmonary surfactant-associated protein B ELISA Kit; SP-B ELISA Kit; Pulmonary surfactant-associated proteolipid SPL(Phe) ELISA Kit
  • 縮寫：
    SFTPB
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    0.45 ng/mL-30 ng/mL
  • 靈敏度：
    0.11 ng/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse SP-B in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %92
    Range %86-97
    1:2Average %97
    Range %92-102
    1:4Average %88
    Range %85-93
    1:8Average %89
    Range %83-94
  • 回收率：
    The recovery of mouse SP-B spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9187-96
    EDTA plasma (n=4)10296-109
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/mlOD1OD2AverageCorrected
    302.176 2.206 2.191 2.031
    151.511 1.544 1.528 1.368
    7.50.897 0.970 0.934 0.774
    3.750.612 0.618 0.615 0.455
    1.80.362 0.392 0.377 0.217
    0.90.279 0.267 0.273 0.113
    0.450.225 0.220 0.223 0.063
    00.156 0.163 0.160
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter.
  • 基因功能參考文獻：
    1. Surfactant protein B suppresses lung cancer progression by inhibiting secretory phospholipase A2 activity and arachidonic acid production. PMID: 28743125
    2. These data provided a plausible mechanism linking maternal vitamin D deficiency with altered postnatal lung function. PMID: 27121020
    3. Surfactant protein B had decreased levels in influenza A virus PR8-infected cells, which was confirmed by immunoblotting and immunofluorescence assays. PMID: 25965799
    4. macrophages participate in the repression of SFTPB expression by LPS, and that macrophage-released cytokines (including TNF) regulate the transcription factor CEBPB PMID: 23590297
    5. ErbB4 regulates the expression of surfactant protein B in fetal lung maturation, helping to prepare for the fetal-neonatal transition. PMID: 21317380
    6. The stimulatory effects of estrogen on Sftpb are under transcriptional control of ErbB4. PMID: 21777626
    7. SP-B contributes to innate host defense of the lung by supplementing the nonoxidant antimicrobial defenses of alveolar macrophages PMID: 20007532
    8. DNA methylation and chromatin modifications cooperate with Nkx2-1 to regulate Sftpb gene cell specific expression. PMID: 19906647
    9. formation of the intersubunit disulfide bridge is not critical for SP-B function PMID: 12133857
    10. The late asthmatic response is linked with increased surface tension and reduced surfactant protein B in mice. PMID: 12225952
    11. This protein inhibits endotoxin-induced lung inflammation. PMID: 12594064
    12. Reduction of alveolar SP-B content causes surfactant dysfunction and respiratory failure, indicating that SP-B is required for postnatal lung function. PMID: 12639841
    13. SP-B expression is regulated by PPARgamma in the lung PMID: 12829715
    14. napsin, cathepsin H, and at least one other enzyme are involved in maturation of the biologically active SP-B peptide PMID: 14766755
    15. Results indicate that hypoxia-induced mitogenic factor induces surfactant protein B and C production in mouse lungs and cell lines via activation of phosphatidylinositol 3-kinase/Akt and ERK1/2 mitogen-activated protein kinases. PMID: 16166744
    16. absence of HO-1 in the lung parenchyma, not in bone marrow-derived inflammatory cells, was responsible for enhanced SP-B downregulation and severe physiologic lung dysfunction PMID: 16309574
    17. Via promoter mutation analysis, adjacent TTF-1 binding sites within the proximal promoter region of SP-C were found to be essential for TTF-1/TAP26-enhanced SP-C promoter activity. PMID: 16630564
    18. SP-B controls surface tension by forming a surfactant phospholipid film that regulates shape and nonspecific phagocytic activity of alveolar macrophages on the alveolar surface. PMID: 16632521
    19. ABCA3 is necessary for lamellar body biogenesis, surfactant protein-B processing, and lung development late in gestation. PMID: 17540762
    20. Three novel Sp1 binding motifs were identified in the mouse SP-B promoter. PMID: 19096034
    21. Results support the idea that maintenance of surfactant-associated protein B expression is critical to survival during acute lung injury. PMID: 19131640
    22. The surface tension-lowering properties of Sftpb play an important role in the regulation of pulmonary vascular perfusion. PMID: 19202005
    23. Maintaining Sftpb is critical to survival during acute lung injury PMID: 19131640

    顯示更多

    收起更多

  • 亞細胞定位：
    Secreted, extracellular space, surface film.
  • 數據庫鏈接：


主站蜘蛛池模板： 久久ee热这里只有精品| 香蕉久久久久久久av网站| 国产精品美女乱子伦高| 夜精品一区二区无码a片| 在线а√天堂中文官网| 图片小说视频一区二区| 成人看片黄a免费看在线| 日本伦奷在线播放| 国产内射爽爽大片| 99精品国产在热久久婷婷| 亚洲日韩片无码中文字幕| 无码日韩人妻av一区免费| 狠狠躁天天躁中文字幕无码| 中文字幕乱码人妻一区二区三区| 欧美成人精品三级一二三在线观看| 99精品国产高清一区二区麻豆| 精品一区二区三区无码av久久| 中文天堂在线www| 久久久久久国产精品美女| 青青草国产精品久久久久| 国产成人精品久久| 特级无码毛片免费视频尤物| 97se狠狠狠狠狼鲁亚洲综合色 | 99精品免视看| 欧美颜射内射中出口爆在线| 深夜国产一区二区三区在线看| 日韩av无码一区二区三区无码| 国内揄拍国内精品少妇| 中文字幕aⅴ人妻一区二区 | 久久综合久久自在自线精品自| 国产亚洲精品久久无码98| 久久免费的精品国产v∧| 中文字幕日产熟女乱码| 最新777第四色米奇影视| 一本大道伊人av久久乱码| 成人无码www在线看免费| 男女性爽大片视频免费看| 久久久久人妻精品一区三寸蜜桃| 香蕉免费一区二区三区在 | 日本丰满熟妇videos| 国产+日韩+另类+视频一区|