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Mouse Oncostatin-M,OSM ELISA KIT

  • 中文名稱:
    小鼠抑瘤素M(OSM)酶聯免疫試劑盒
  • 貨號:
    CSB-E04697m
  • 規格:
    96T/48T
  • 價格:
    ¥3800/¥2500
  • 其他:

產品詳情

  • 產品描述:
    小鼠抑瘤素M(OSM)酶聯免疫試劑盒(CSB-E04697m)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織培養上清液、組織勻漿樣本中的OSM含量。小鼠抑瘤素M(OSM)是一種多功能細胞因子,屬于白細胞介素6家族,具有抑制腫瘤細胞生長、調節炎癥反應、刺激造血等作用。其通過JAK-STAT及MAPK信號通路介導生物學效應,參與肝臟再生、肝臟疾病等多種生理病理過程。試劑盒檢測范圍為3.12 pg/mL-200 pg/mL,適用于科研領域探索OSM在炎癥模型、腫瘤發展、器官纖維化等病理生理過程中的動態變化,例如評估疾病動物模型中OSM的表達水平、分析藥物或基因干預對OSM分泌的影響,或結合細胞實驗研究OSM的信號通路機制本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
  • 別名:
    Osm ELISA Kit; Oncostatin-M ELISA Kit; OSM ELISA Kit
  • 縮寫:
  • Uniprot No.:
  • 種屬:
    Mus musculus (Mouse)
  • 樣本類型:
    serum, plasma, cell culture supernates, tissue homogenates
  • 檢測范圍:
    3.12 pg/mL-200 pg/mL
  • 靈敏度:
    0.78 pg/mL
  • 反應時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領域:
    Immunology
  • 測定原理:
    quantitative
  • 測定方法:
    Sandwich
  • 精密度:
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度:
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse OSM in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:20Average %93
    Range %88-97
    1:40Average %84
    Range %80-88
    1:80Average %95
    Range %90-100
    1:160Average %98
    Range %94-105
  • 回收率:
    The recovery of mouse OSM spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9185-96
    EDTA plasma (n=4)104100-108
  • 標準曲線:
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1OD2AverageCorrected
    2002.234 2.151 2.193 2.014
    1001.715 1.807 1.761 1.582
    501.234 1.154 1.194 1.015
    250.779 0.813 0.796 0.617
    12.50.587 0.612 0.600 0.421
    6.250.353 0.345 0.349 0.170
    3.120.271 0.257 0.264 0.085
    00.183 0.175 0.179
  • 數據處理:
  • 貨期:
    3-5 working days

產品評價

靶點詳情

  • 功能:
    Growth regulator. Inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses only type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration.
  • 基因功能參考文獻:
    1. Oncostatin M is a secreted niche factor responsible for quiescence induction PMID: 29670077
    2. data revealed that OSM alleviated postinfarction cardiac remodeling and dysfunction by enhancing cardiomyocyte autophagy. OSM holds promise as a therapeutic target in treating HF after MI through Obeta receptor by inhibiting Mst1 phosphorylation. PMID: 27825852
    3. TRAF5 is crucially involved in OSM-mediated lung inflammation probably by inducing lung stromal/fibroblast cell activation. PMID: 29596835
    4. OSM mitigated the proliferation of Th17 cells and decreased the expression of IL-17 and IL-21; it promoted the activation of suppressor of cytokine signaling 3 (SOCS3), STAT3, and STAT5; observations suggest that OSM can inhibit Th17 differentiation by reciprocally controlling SOCS3, STAT3, and STAT5 PMID: 28093521
    5. In an animal model of anti-TNF-resistant intestinal inflammation, genetic deletion or pharmacological blockade of OSM significantly attenuates colitis. PMID: 28368383
    6. these results support the proinflammatory role of OSM when it is overexpressed in the skin. However, OSM expression was not required in the murine model of psoriasis induced by topical application of imiquimod, as demonstrated by the inflammatory phenotype of OSM-deficient mice or wild-type mice treated with anti-OSM antibodies. PMID: 27122058
    7. Loss of Oncostatin M Signaling in Adipocytes Induces Insulin Resistance and Adipose Tissue Inflammation in Vivo. PMID: 27325693
    8. mechanism of OSM-induced cardiomyocyte dedifferentiation is associated with B-Raf/Mek/Erk signaling pathway through the OSM receptor Obeta PMID: 26837420
    9. Oncostatin M and interleukin-31: Cytokines, receptors, signal transduction and physiology. PMID: 26198770
    10. OSM plays multiple critical roles in the maintenance and development of the hematopoietic microenvironment in the bone marrow at a steady state as well as after injury. PMID: 25551451
    11. OSM treatment preserved cardiac function, inhibited apoptosis and fibrosis, and stimulated angiogenesis via upregulating VEGF and bFGF in infarct border zone of ischemic myocardium, indicating that OSM could be a novel therapeutic target for MI. PMID: 26146616
    12. OSM-induced osteogenesis and upregulation of osteogenic gene products require activity of PKCdelta. PMID: 25634144
    13. administration of Fstl1 induced airway remodeling and increased OSM, whereas administration of an anti-OSM Ab blocked the effect of Fstl1 on inducing airway remodeling, eosinophilic airway inflammation PMID: 26355153
    14. A novel role for OSM during pneumonia as an important signal to epithelial cells for chemokine induction mediating neutrophil recruitment. PMID: 25692402
    15. These results suggest that mOSM, a product of macrophages, sustains intramembranous bone formation by signaling through Osmr and Stat3, acting on the recruitment, proliferation, and/or osteoblast differentiation of endosteal mesenchymal progenitor cells. PMID: 25559270
    16. In astrocytes but not microglia, phosphorylation of STAT1 and STAT3 occurred in response to OSM, whereas both microglia and astrocytes responded to hyper-IL-6 (IL-6 linked to the soluble IL-6 receptor). PMID: 25103368
    17. Following spinal cord injury, OSM is produced at the lesion site, where it protects the CNS from further damage and promotes recovery PMID: 24996996
    18. OSM promotes tumour growth, and does so through altering the local lung environment with accumulation of M2 macrophages. PMID: 24976180
    19. these results support the ability of OSM to induce B cell activation and iBALT formation independently of IL-6 and highlight a role for IL-6 downstream of OSM in the induction of pulmonary inflammation. PMID: 23797667
    20. Oncostatin M induces thermal hypersensitivity by directly sensitizing nociceptors via OSMR-gp130 receptor mediated potentiation of TRPV1. PMID: 22196363
    21. Oncostatin M (OSM), a cytokine of the IL-6 family, was identified as a major coupling factor produced by activated circulating CD14+ or bone marrow CD11b+ monocytes/macrophages. PMID: 22267310
    22. Oncostatin M (OSM) is a major mediator of cardiomyocyte dedifferentiation and remodeling during acute myocardial infarction (MI) and in chronic dilated cardiomyopathy (DCM). PMID: 22056139
    23. we show that Oncostatin M (Osm) and its receptor, OsmRbeta, are both expressed in the subventricular zone and that Osm directly inhibits the proliferation of adult neural precursor cells PMID: 21671408
    24. OSM is expressed in atherosclerotic lesions and may contribute to the progression of atherosclerosis by promoting SMC proliferation, migration and extracellular matrix protein synthesis through the STAT pathway PMID: 21376322
    25. Loss of oncostatin M is associated with chondrosarcoma. PMID: 21344373
    26. Overexpression of mouse oncostatin M induces STAT6-dependent pulmonary eosinophilia, mucous/goblet cell hyperplasia, and airway hyperresponsiveness but STAT6-independent mechanisms of lung tissue extracellular matrix accumulation. PMID: 21160052
    27. These studies are the first to demonstrate the proinflammatory effects of OSM in microglia, and also identify IL-27 as a novel inhibitor of inflammatory processes in these cells. PMID: 20468050
    28. Findings provide evidence that the inflammatory cytokine oncostatin M is involved in modulation of the Ang-Tie system by increasing Ang2 expression in human endothelial cells in vitro, and in murine hearts and human hearts in vivo. PMID: 20088942
    29. these results indicate that OSM may play a role in innate immunity and in acquired immunity by enhancing DCs maturation and promoting Th1 immune responses. PMID: 20206608
    30. Oncostatin M (OSM) is produced by osteoblasts and osteocytes in mouse bone and that it has distinct effects when acting through 2 different receptors. PMID: 20051625
    31. Results show that oncostatin M favors bone apposition at periosteal sites instead of resorption in vivo, and this effect was not dependent on or inhibited by IL-6. PMID: 12000725
    32. role for OSM in inflammatory responses that can modulate steady-state ECM deposition in Balb/C mice PMID: 12023835
    33. Th1 cells regulate hematopoietic progenitor cell homeostasis by production of oncostatin M PMID: 12121663
    34. Oncostatin M stimulates (45)Ca release and enhances mRNA expression of receptor activator of NF-kappa B ligand (RANKL) and osteoprotegerin in neonatal calvarial bone cultures, but has no effect on the expression of RANK. PMID: 12218157
    35. oncostatin m mRNA-positive cells were found in hematopoietic organs during development PMID: 12412016
    36. OSM induces eotaxin expression in mouse fibroblasts at the protein and mRNA level, and adenovirus vector-encoding OSM induces eosinophilia in the lung in vivo following intranasal administration. PMID: 12496442
    37. Mouse OSM upregulates MMP-9 expression in rat smooth muscle cells through the MEK-ERK but not STAT3 pathway. PMID: 12615664
    38. Oncostatin M (OM) transforms the lymph node (LN) into a "super lymphoid organ" with 2 striking features: massive thymus-independent T-cell development and major expansion of the memory T-cell pool. PMID: 12702501
    39. Oncostatin M[OSM]-deficient mice displayed significantly reduced noxious responses in models of acute pain. Thus, OSM plays an essential role in the development of a subtype of nociceptive neurons in the dorsal root ganglia PMID: 14985435
    40. OSM causes a loss of cell-cell and cell-substratum adhesion ending in cell detachment from monolayer culture. OSM induces the expression of Cox-2. It could contribute to the development of a metastatic phenotype in vivo. PMID: 15168734
    41. Oncostatin M in combination with either IL-1 or tumour necrosis factor alpha represents cytokine combinations that promote bone destruction. PMID: 15642143
    42. Oncostatin M uniquely induces significant release of keratinocyte-derived chemokine (KC) and lipopolysaccharide-induced chemokine (LIX) in mouse cardiac fibroblasts. PMID: 16452159
    43. role of OSM in regulation of VCAM-1 expression, and STAT6 tyrosine 641 phosphorylation in murine fibroblasts PMID: 16547273
    44. OSM arrests skeletal muscle cell growth at the G1/S checkpoint and this response occurs by an ubiquitin/proteasome-dependent cyclin D1 protein reduction which is regulated by STAT3 PMID: 17976956
    45. Both LY294002 and PD98059 attenuated Oncostatin M-induced phosphorylation of ERK1/2 MAP kinase and also reduced binding of an AP-1 responsive promoter element, a transcriptional complex known to be MAPK-sensitive. PMID: 18372159
    46. A dual role for oncostatin M signaling in the differentiation and death of mammary epithelial cells in vivo. PMID: 18927239
    47. The expression of SCGB3A1 and SCGB3A2 are bidirectionally regulated by oncostatin M (OSM) when examined in a mouse transformed Clara cell line. PMID: 18978304
    48. Results suggest that OSM plays a key role in the prevention of autoimmune disease by regulating the clearance of apoptotic thymocytes. PMID: 19384873

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  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    LIF/OSM family
  • 數據庫鏈接:


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