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Mouse C-Reactive Protein,CRP ELISA Kit

  • 中文名稱:
    小鼠C反應蛋白(CRP)酶聯免疫試劑盒
  • 貨號:
    CSB-E07923m(1)
  • 規格:
    96T/48T
  • 價格:
    ¥3800/¥2500
  • 其他:

產品詳情

  • 產品描述:
    小鼠C反應蛋白(CRP)酶聯免疫試劑盒(CSB-E07923m(1))為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織勻漿樣本中的CRP含量。CRP即C反應蛋白,是一種急性時相反應蛋白。在炎癥、感染、組織損傷等情況下,其血漿濃度會急劇升高。研究發現,CRP可激活補體系統等參與機體免疫反應,還能反映炎癥程度,在疾病診斷、病情監測等方面發揮重要作用。試劑盒檢測范圍為5 ng/mL-4000 ng/mL,適用于小鼠炎癥模型研究、心血管疾病機制探索或藥物干預后炎癥水平變化的動態監測;可滿足基礎醫學、藥理學等領域對炎癥相關指標的檢測需求,為實驗動物模型的病理機制研究提供可靠數據支持。本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
  • 別名:
    Crp ELISA Kit; Ptx1C-reactive protein ELISA Kit
  • 縮寫:
  • Uniprot No.:
  • 種屬:
    Mus musculus (Mouse)
  • 樣本類型:
    serum, plasma, tissue homogenates
  • 檢測范圍:
    5 ng/mL-4000 ng/mL
  • 靈敏度:
    5 ng/mL
  • 反應時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領域:
    Immunology
  • 測定原理:
    quantitative
  • 測定方法:
    Sandwich
  • 數據處理:
  • 貨期:
    3-5 working days

產品評價

靶點詳情

  • 最新研究進展:
    C反應蛋白(CRP)是一種急性相蛋白,可被廣泛應用于臨床診斷、治療和預后。最近的研究表明,CRP不僅僅是炎癥的標志物,它還可以直接調節免疫細胞的活動,例如刺激單核細胞的化學吸引和激活T細胞等。此外,一些研究還發現CRP可能與肥胖、代謝綜合征、心血管疾病等相關聯。
  • 功能:
    Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
  • 基因功能參考文獻:
    1. CRP is pathogenic in type-2 diabetes (T2DN). CRP may promote CD32b- NF-kappaB signaling to mediate renal inflammation; whereas, CRP may enhance renal fibrosis in T2DN via CD32b-Smad3-mTOR signaling. PMID: 27221338
    2. FcgammaRIIb and FcgammaRIII are involved in the CRP-induced expression of MMPs and TIMP-1 and the CRP-induced phosphorylation of p38, whereas the FcgammaR-independent pathway may regulate the CRP-induced MMP-11 expression and the CRP-induced ERK1/2 phosphorylation. PMID: 28539825
    3. C-reactive protein may promote acute kidney injury by impairing tubular epithelial cell regeneration via the CD32-Smad3-p27-driven inhibition of the CDK2/cyclin E complex. PMID: 27470679
    4. These results suggested that CRP/oxidized low density lipoprotein/beta 2-Glycoprotein I complexes may induce lipid accumulation and inflammation in macrophages via the p38/MAPK and NFkappaB signaling pathways. PMID: 27512978
    5. these data unexpectedly identify CBS as the major recognition site of mCRP and suggest that this motif may be exploited to tune the proinflammatory actions of mCRP. PMID: 26907682
    6. CRP decreased adiponectin expression and multimerization, while CRP-induced decline in adiponectin might be mediated through the PI3K/Akt pathway. PMID: 26812237
    7. mCRP may be responsible for promoting dementia after ischaemia and mCRP clearance could inform therapeutic avenues to reduce the risk of future dementia. PMID: 26335098
    8. Effects of C-Reactive Protein on the Cardiac Differentiation of Mouse Embryonic Stem Cells PMID: 26328491
    9. These data indicated that CRP may have a direct role on osteoclast and osteoblast differentiation via toll-like receptor signaling pathways. PMID: 26687448
    10. Data suggest that serum amyloid P (SAP) activates CD209 DC-SIGN to regulate the innate immune system differently from C-reactive protein (CRP), and that DC-SIGN is a target for antifibrotics. PMID: 26106150
    11. the acute phase protein C-reactive protein (CRP), a ligand for Fc receptors on phagocytes, enhances antibody-mediated platelet destruction by phagocytes in vivo PMID: 25548320
    12. CRP has therapeutic potential against cancer through decreasing the accumulation of M2 macrophages and angiogenesis within tumors. PMID: 25088786
    13. Orphan nuclear receptor Errgamma induces C-reactive protein gene expression through induction of ER-bound Bzip transmembrane transcription factor CREBH. PMID: 24466039
    14. The interactions of CRP and the BBB are a two-phase process, with increased paracellular permeability at a high dose that enables its entry into the CNS and serves to induce reactive gliosis and impair CNS function. PMID: 23018453
    15. In mice with photochemically induced thrombosis, acrolein produced at the locus of infarction increased the level of IL-6 and then CRP in plasma. PMID: 23763486
    16. CRP directly inhibits tumoral lymphangiogenesis and lymph node metastasis in mice. PMID: 23859309
    17. Which processes in glucose homeostasis are altered by CRP? Data suggest that CRP attenuates insulin-induced skeletal muscle blood flow; CRP contributes to insulin resistance via IgG receptor IIB-mediated inhibition of glucose delivery to muscle. PMID: 23069625
    18. CRP is not only a biomarker, but also a mediator in DKD. PMID: 21744073
    19. C-reactive protein promotes acute renal inflammation and fibrosis in unilateral ureteral obstructive nephropathy in mice. PMID: 21383672
    20. These findings reveal a novel nutrient-dependent interaction between Sirt1 and HNF-1alpha which results in regulation of Crp expression. PMID: 21176092
    21. Studies show that CRP itself may have a pathogenic role in the development of pressure overload-induced cardiac remodeling, possibly through enhanced inflammation and oxidative stress. PMID: 21220701
    22. No reduction of atherosclerosis in C-reactive protein (CRP)-deficient mice. PMID: 21149301
    23. Modified and natural C-reactive protein have opposite effects on atherosclerosis in apolipoprotein E-deficient mice. PMID: 16087790
    24. the contribution of CRP's ability of activating the classical pathway of complement in the protection of mice from lethal infection with virulent Streptococcus pneumoniae type 3 PMID: 16547275
    25. nCRP can facilitate cardiovascular disease through impairment of endothelium-dependent vasoreactivity, in a manner that involves increased iNOS activity and a potential for increased peroxynitrite formation. PMID: 17669410
    26. the response to vascular injury provoked by human C-Reactive Protein in ovariectomized C-reactive protein transgenic mice depends on Fc gamma RI and probably requires its expression by F4/80+ cells PMID: 18063701
    27. In vivo analyses revealed significant increases in TF expression and decreases in TFPI expression in carotid arteries of CRP-Tg mice versus WT mice. PMID: 18276908
    28. CRP plays a crucial role in the induction, amplification, and prolongation of inflammatory processes, including atherosclerotic lesions PMID: 18402807
    29. C-reactive protein has a role in impaired endothelial function PMID: 18433756

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  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    Pentraxin family
  • 組織特異性:
    Found in plasma.
  • 數據庫鏈接:


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