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  4. Human glypican 6 (GPC6) ELISA kit

Human glypican 6 (GPC6) ELISA kit

  • 中文名稱：
    人磷脂酰肌醇蛋白聚糖6(GPC6)酶聯免疫試劑盒
  • 貨號：
    CSB-EL009708HU
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    人磷脂酰肌醇蛋白聚糖6(GPC6)酶聯免疫試劑盒（CSB-EL009708HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、細胞裂解物樣本中的GPC6含量。GPC6 是一個靶點。它在人體生理和病理過程中有重要作用。研究發現其參與細胞信號傳導等機制。圍繞它探究疾病發生發展機制、尋找有效治療靶點是當前研究方向，有望為相關疾病如特定癌癥等的診治帶來新突破。試劑盒檢測范圍為0.312 ng/mL-20 ng/mL，適用于腫瘤生物學研究、細胞信號轉導機制探索、骨骼發育相關實驗等科研領域本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    A Kit; Glypican 6 [Precursor] ELISA Kit; Glypican proteoglycan 6 ELISA Kit; Gpc6 ELISA Kit; GPC6_HUMAN ELISA Kit; MGC126288 ELISA Kit; OMIMD1 ELISA Kit; PRO705 ELISA Kit; Secreted glypican 6 ELISA Kit; Secreted glypican-6 ELISA Kit; UNQ369 ELISA Kit
  • 縮寫：
    GPC6
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍：
    0.312 ng/mL-20 ng/mL
  • 靈敏度：
    0.078 ng/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human GPC6 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 87
    Range % 82-91
    1:2 Average % 94
    Range % 89-98
    1:4 Average % 107
    Range % 103-110
    1:8 Average % 110
    Range % 104-114
  • 回收率：
    The recovery of human GPC6 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 95 91-99
    EDTA plasma (n=4) 103 98-108
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average Corrected
    20 2.443 2.403 2.423 2.271
    10 1.692 1.702 1.697 1.545
    5 1.218 1.268 1.243 1.091
    2.5 0.854 0.865 0.860 0.708
    1.25 0.602 0.612 0.607 0.455
    0.625 0.413 0.403 0.408 0.256
    0.312 0.274 0.268 0.271 0.119
    0 0.153 0.150 0.152 　
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases. Enhances migration and invasion of cancer cells through WNT5A signaling.
  • 基因功能參考文獻：
    1. Thus, GPC6 and TMEM132D may serve as predictors of CD8+ T-lymphocyte infiltration and as favorable prognostic markers in early stage ovarian cancer with important consequences for diagnosis. PMID: 26448945
    2. Extracellular matrix proteins expression profiling in chemoresistant variants of the A2780 ovarian cancer cell line. PMID: 24804215
    3. GPC6 promotes invasive migration by inhibition of canonical beta-catenin and Wnt signalling, and up-regulation of non-canonical Wnt5A signalling leading to the activation of JNK and p38 MAPK. PMID: 21871017
    4. a reduction in GPC6 mRNA in retinoblastoma is associated with the non-random allelic loss at 13q31 that could contribute to RB development. PMID: 19726429
    5. Mutations in the heparan-sulfate proteoglycan glypican 6 impair endochondral ossification and cause recessive omodysplasia PMID: 19481194

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  • 相關疾病：
    Omodysplasia 1 (OMOD1)
  • 亞細胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.; [Secreted glypican-6]: Secreted, extracellular space.
  • 蛋白家族：
    Glypican family
  • 組織特異性：
    Widely expressed. High expression in fetal kidney and lung and lower expressions in fetal liver and brain. In adult tissues, very abundant in ovary, high levels also observed in liver, kidney, small intestine and colon. Not detected in peripheral blood le
  • 數據庫鏈接：

    HGNC: 4454

    OMIM: 258315

    KEGG: hsa:10082

    STRING: 9606.ENSP00000366246

    UniGene: Hs.444329



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