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  4. Human Thrombospondin type-1 domain-containing protein 4(THSD4) ELISA kit

Human Thrombospondin type-1 domain-containing protein 4(THSD4) ELISA kit

  • 中文名稱：
    人血小板反應(yīng)素1型結(jié)構(gòu)域蛋白4(THSD4)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL023518HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人血小板反應(yīng)素1型結(jié)構(gòu)域蛋白4(THSD4)酶聯(lián)免疫試劑盒（CSB-EL023518HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織培養(yǎng)上清液、組織勻漿樣本中的THSD4含量。THSD4是一種預(yù)測具有水解酶活性和細胞外基質(zhì)結(jié)構(gòu)成分的蛋白，可能在彈性纖維組件中起作用，位于含膠原蛋白的細胞外基質(zhì)和細胞外外泌體中。其研究機制涉及遺傳性血小板病，如巨血小板綜合征和血小板無力癥，以及其在止血、炎癥和免疫反應(yīng)中的作用。試劑盒檢測范圍為12.5 pg/mL-800 pg/mL，該產(chǎn)品適用于基礎(chǔ)研究中對THSD4表達水平的定量分析，如探究其在心血管疾病、纖維化病變或腫瘤進展中的分子機制，亦可用于體外培養(yǎng)細胞模型中THSD4分泌水平的動態(tài)監(jiān)測。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    THSD4 ELISA Kit; UNQ9334/PRO34005 ELISA Kit; Thrombospondin type-1 domain-containing protein 4 ELISA Kit; A disintegrin and metalloproteinase with thrombospondin motifs-like protein 6 ELISA Kit; ADAMTS-like protein 6 ELISA Kit; ADAMTSL-6 ELISA Kit
  • 縮寫：
    THSD4
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, cell culture supernates, tissue homogenates
  • 檢測范圍：
    12.5 pg/mL-800 pg/mL
  • 靈敏度：
    3.12 pg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%      
    Three samples of known concentration were tested twenty times on one plate to assess.  
    Inter-assay Precision (Precision between assays): CV%<10%      
    Three samples of known concentration were tested in twenty assays to assess.    
                 
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human THSD4 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)  
    1:20 Average % 88  
    Range % 81-95  
    1:40 Average % 91  
    Range % 86-97  
    1:80 Average % 97  
    Range % 91-102  
    1:160 Average % 102  
    Range % 97-107  
  • 回收率：
    The recovery of human THSD4 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range  
    Serum (n=5) 103 95-110  
    EDTA plasma (n=4) 93 85-98  
                 
                 
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected  
    800 2.675 2.870 2.773 2.674  
    400 2.324 2.345 2.335 2.236  
    200 1.618 1.655 1.637 1.538  
    100 0.864 0.901 0.883 0.784  
    50 0.502 0.496 0.499 0.400  
    25 0.324 0.345 0.335 0.236  
    12.5 0.198 0.200 0.199 0.100  
    0 0.101 0.096 0.099 　  
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN.
  • 基因功能參考文獻：
    1. In breast cancer, some GATA3 effects shift from tumor suppressing to tumor promoting during tumorigenesis, with deregulation of three genes, BCL2, DACH1, THSD4, representing major GATA3-controlled processes in cancer progression. PMID: 25410484
    2. ADAMTSL6beta has a role in fibrillin-1 microfibril formation PMID: 21880733
    3. THSD4 polymorphism was not found to be associated with COPD risk PMID: 21965014
    4. Variations may be important determinants of osteoporosis in Japanese women. PMID: 18488137
  • 亞細胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 25835

    OMIM: 614476

    KEGG: hsa:79875

    STRING: 9606.ENSP00000261862

    UniGene: Hs.387057



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