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  4. Human Neuronal pentraxin-2(NPTX2) ELISA kit

Human Neuronal pentraxin-2(NPTX2) ELISA kit

  • 中文名稱：
    人神經穿透素-2(NPTX2)酶聯免疫試劑盒
  • 貨號：
    CSB-EL016030HU
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    人神經穿透素-2(NPTX2)酶聯免疫試劑盒（CSB-EL016030HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的NPTX2含量。試劑盒檢測范圍為0.156 ng/mL-10 ng/mL，適用于體外實驗中探索NPTX2在神經退行性疾病模型、神經損傷修復機制或腦組織蛋白表達調控等領域的生物學功能；科研人員可通過定量分析不同病理生理條件下NPTX2的濃度變化，為神經科學基礎研究提供可靠工具本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    apexin ELISA Kit; NARP ELISA Kit; neuronal activity-regulated pentaxin ELISA Kit; Neuronal pentraxin 2 ELISA Kit; Neuronal pentraxin II ELISA Kit; Neuronal pentraxin-2 ELISA Kit; NP 2 ELISA Kit; NP-II ELISA Kit; NP2 ELISA Kit; NPII ELISA Kit; NPTX2 ELISA Kit; NPTX2_HUMAN ELISA Kit; pentraxin II, neuronal ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    0.156 ng/mL-10 ng/mL
  • 靈敏度：
    0.039 ng/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Neuroscience
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%        
    Three samples of known concentration were tested twenty times on one plate to assess.    
    Inter-assay Precision (Precision between assays): CV%<10%        
    Three samples of known concentration were tested in twenty assays to assess.      
                   
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human NPTX2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.  
    　 Sample Serum(n=4)    
    1:1 Average % 96    
    Range % 91-100    
    1:2 Average % 104    
    Range % 100-110    
    1:4 Average % 91    
    Range % 85-95    
    1:8 Average % 93    
    Range % 89-97    
  • 回收率：
    The recovery of human NPTX2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.  
     
    Sample Type Average % Recovery Range    
    Serum (n=5) 95 90-100    
    EDTA plasma (n=4) 84 80-88    
                   
                   
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.  
     
    ng/ml OD1 OD2 Average Corrected    
    10 2.520 2.385 2.453 2.304    
    5 1.571 1.496 1.534 1.385    
    2.5 0.919 0.973 0.946 0.797    
    1.25 0.525 0.557 0.541 0.392    
    0.625 0.352 0.329 0.341 0.192    
    0.312 0.268 0.254 0.261 0.112    
    0.156 0.193 0.201 0.197 0.048    
    0 0.145 0.152 0.149 　    
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner.
  • 基因功能參考文獻：
    1. Neuronal pentraxin 2 predicts medial temporal atrophy and memory decline across the Alzheimer's disease spectrum. This research may advance the current understanding of Alzheimer's disease etiopathogenesis, while expanding early diagnostic techniques through the use of novel pro-inflammatory biomarkers, such as NPTX2. PMID: 27444967
    2. NPTX2 in human cerebrospinal fluid is reduced in subjects with Alzheimer's disease and shows robust correlations with cognitive performance and hippocampal volume. PMID: 28440221
    3. Decreased NPTX2 expression in rectal adenocarcinomas is associated with improved response to neoadjuvant chemoradiation and improved prognosis. PMID: 27083956
    4. we show that NPTX2 is a marker of poor prognosis for neuroblastoma patients. PMID: 26294210
    5. NPTX2 is overexpressed specifically in ccRCC primary tumors. PMID: 24962026
    6. NPTX2 repressed NF-kappaB activity by inhibiting AKT through a p53-PTEN-dependent pathway, thus explaining the hypermethylation and downregulation of NPTX2 in NF-kappaB-activated high-risk glioblastomas. PMID: 24078801
    7. Promoter methylation of NPTX2 is associated with glioblastoma. PMID: 23624749
    8. Detection of aberrant methylation of NPTX2 in pure pancreatic juice samples could be useful as a molecular marker to discriminate between patients with malignant and benign disease of the pancreas PMID: 23360791
    9. The visual cortex of NARP-deficient transgenic mice is hyperexcitable and unable to express ocular dominance, although many aspects of visual function are unimpaired. PMID: 23889936
    10. This study showed that the NPTX2 protein is down-regulated in human primary pancreatic cancers and in pancreatic cancer cell lines. PMID: 22806544
    11. This study demonistrated that childhood-onset mood disorders and suicide attempt association between HOMER1 rs2290639 and between NPTX2 markers rs705315 and rs1681248. PMID: 22460132
    12. Demonstrate for the first time that NARP mutation significantly enhances apoptotic death as a result of three distinct lethal mitochondrial apoptotic insults including oxidative, Ca(2+), and lipid stress. PMID: 21812817
    13. Data indicate that the aberrantly methylated NPTX2 gene may help to distinguish between chronic pancreatitis and pancreatic cancer with conventional diagnostic tools and could become a valuable diagnostic marker. PMID: 21778928
    14. NPTX2, as a tumor-suppressor, plays an anti-tumor effect on pancreatic cancer and its low expression, due to promoter hypermethylation, may play a role in the tumorigenesis of pancreatic cancer. PMID: 21161403
    15. study tested for the association of four SNPs of NPTX2 & haplotypes consisting of the SNPs with autism, between autistic patients & controls in a Japanese population; no significant difference was observed in allele, genotype or haplotype frequencies PMID: 17408830
    16. pancreatic cancer cytology samples had statistically significant higher levels of NPTX2 methylation compared with benign diseases PMID: 17895837
    17. Neuronal pentraxin II is highly upregulated in Parkinson's disease and a novel component of Lewy bodies. PMID: 17987278
    18. Homoplasmic cybrids harboring the 8993T-->G NARP mutation were also protected from death (75% vs 15% survival at 72 hours) by the supplemented medium and their ATP content was similar to controls PMID: 19667215

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  • 亞細胞定位：
    Secreted.
  • 組織特異性：
    Brain, pancreas, liver, heart and skeletal muscle. Highest levels are seen in the testis.
  • 數據庫鏈接：

    HGNC: 7953

    OMIM: 600750

    KEGG: hsa:4885

    STRING: 9606.ENSP00000265634

    UniGene: Hs.3281



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